Results 51 to 60 of about 2,094,383 (285)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Flare energy release and avalanche ionization of plasma by runaway electrons in lower solar atmosphere

Open Astronomy, 2022
The analysis of the electron acceleration by the quasi-stationary sub-Dreiser electric fields in the lower solar atmosphere has been done. It has been shown that the Dreiser electric field turned out to be several orders of magnitude larger than coronal ...
Tsap Yuriy, Kopylova Yulia, Karlický Marian   +2 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Electron Acceleration by Interaction of Two Filamentary Currents Within a Magnetopause Magnetic Flux Rope

Geophysical Research Letters, 2023
Two types of filamentary currents (FCs) were observed inside a magnetic flux rope at the magnetopause by the Magnetospheric Multiscale mission. The first FC is identified as an electron vortex, while the other is a reconnecting current sheet.
Shimou Wang, Rongsheng Wang, Quanming Lu, J. L. Burch, Ian J. Cohen, A. N. Jaynes, R. E. Ergun   +6 more
doaj   +1 more source

Electron acceleration in supernova remnants

Plasma Physics and Controlled Fusion, 2022
Abstract Supernova remnants (SNRs) are believed to produce the majority of galactic cosmic rays (CRs). SNRs harbor non-relativistic collisionless shocks responsible for the acceleration of CRs via diffusive shock acceleration (DSA), in which particles gain their energy via repeated interactions with the shock front.
openaire   +4 more sources

ONSET OF ELECTRON ACCELERATION IN A FLARE LOOP [PDF]

The Astrophysical Journal, 2014
We carried out detailed analysis of X-ray and radio observations of a simple flare loop that occurred on 12th August 2002, with the impulsive hard X-ray (HXR) light curves dominated by a single pulse. The emission spectra of the early impulsive phase are consistent with an isothermal model in the coronal loop with a temperature reaching several keVs. A
Sharykin, Ivan, Liu, Siming, Fletcher, Lyndsay   +2 more
openaire   +3 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source