Results 61 to 70 of about 700,935 (209)
Solar-Terrestrial Physics, 2018 The work is devoted to the development of a fundamentally new way of modeling the ionospheric D-region – deterministic-probabilistic. The results of Ne calculations using this technique are analyzed.
Bekker S.Z.
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
On the Sign of Local Temperature in Molecules
Entropy, 1999 : Lin proposed earlier based on qualitative considerations that electronic motion was associated with negative absolute temperature. Here, a local temperature formula is proposed for electronic motion in atoms and molecules, which allows the existence of
István Kolossváry
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Український антарктичний журнал, 2020 We present ionospheric observational results obtained over Ukrainian Antarctic Akademik Vernadsky station. Ionospheric parameters (peak electron density and height, electron density and electron and ion temperatures in the topside) during the period near
O. V. Bogomaz +9 more
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Space WeatherWe analyze the topside electron density and temperature during the superstorm in May 2024 (Mother's Day storm or Gannon storm), using multiple Low‐Earth Orbit (LEO) spacecraft operating at different altitudes, such as Swarm, International Space Station ...
Hosub Song +20 more
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, 2023 Output Data for figure 7 in section 4.Format is:Height PerameterElectron ...
openaire +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source