Results 91 to 100 of about 7,342,079 (348)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Adaptive routing behaviors between “touch-go” and direct electron transfer of pyrogenic carbon to promote phosphorus recovery as vivianite

Water Research X
Microbial extracellular electron transfer (EET) driven by dissimilatory iron reduction bacteria is considered integral to elemental cycles and biochemical transformations, which involves the synthesis of the phosphate mineral vivianite in both natural ...
Danhui Liang, Jifei Chang, Fengai Yang, Yue Wu, Xiaoming Yang, Hongjin Ji, Shu Wang, Xin Wang, Nan Li   +8 more
doaj   +1 more source

Respiratory electron transfer pathways in plant mitochondria

Frontiers in Plant Science, 2014
The respiratory electron transport chain (ETC) couples electron transfer from organic substrates onto molecular oxygen with proton translocation across the inner mitochondrial membrane.
Peter eSchertl, Hans-Peter eBraun
doaj   +1 more source

Detecting charge transfer at defects in 2D materials with electron ptychography [PDF]

, 2023
Christoph K. Hofer, Jacob Madson, Toma Susi, Timothy J. Pennycook   +3 more
openalex   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Engineering Shewanella oneidensis‐Carbon Felt Biohybrid Electrode Decorated with Bacterial Cellulose Aerogel‐Electropolymerized Anthraquinone to Boost Energy and Chemicals Production

Advanced Science
Interfacial electron transfer between electroactive microorganisms (EAMs) and electrodes underlies a wide range of bio‐electrochemical systems with diverse applications.
Qijing Liu, Wenliang Xu, Qinran Ding, Yan Zhang, Junqi Zhang, Baocai Zhang, Huan Yu, Chao Li, Longhai Dai, Cheng Zhong, Wenyu Lu, ZhanYing Liu, Feng Li, Hao Song   +13 more
doaj   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Extracellular DNA Promotes Efficient Extracellular Electron Transfer by Pyocyanin in Pseudomonas aeruginosa Biofilms

Cell, 2019
Extracellular electron transfer (EET), the process whereby cells access electron acceptors or donors that reside many cell lengths away, enables metabolic activity by microorganisms, particularly under oxidant-limited conditions that occur in ...
Scott H. Saunders, Edmund C. M. Tse, M. Yates, Fernanda Jiménez Otero, S. Trammell, E. Stemp, J. Barton, L. Tender, D. Newman   +8 more
semanticscholar   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Medium Effects in Photoinduced Electron Transfer Reactions

CHIMIA, 1988
The transfer of an electron between two molecules is a fundamental chemical process of great significance in biochemistry as well as in general chemistry.
Paul Suppan
doaj   +1 more source