Results 91 to 100 of about 1,367,357 (339)

The CDK12–BRCA1 signaling axis mediates dinaciclib‐associated radiosensitivity through p53‐mediated cellular senescence

Molecular Oncology, EarlyView.
Dinaciclib blocks CDK12 activity, leading to downregulation of BRCA1, and probably other proteins involved in homologous recombination, promoting nonhomologous end joining. In this scenario, the presence of ionising radiation triggers a p53‐dependent senescent response that yields increased radiosensitivity. Pan‐cyclin‐dependent‐kinase (CDK) inhibitors
Natalia García Flores, Diego M. Fernández‐Aroca, Cristina Garnés‐García, Andrés Domínguez‐Calvo, Jaime Jiménez‐Suárez, Sebastià Sabater, Pablo Fernández‐Aroca, Ignacio Andrés, Francisco J. Cimas, Guillermo de Cárcer, Borja Belandia, Ignacio Palmero, Pablo Huertas, María José Ruiz‐Hidalgo, Ricardo Sánchez‐Prieto   +14 more
wiley   +1 more source

ELECTRON BEAM TRANSPORT IN DIELECTRIC TUBES

East European Journal of Physics, 2014
The present paper outlines the results of experimental studying the transport process of pulse high-current beam of electrons about 200 ns in duration with energy under 200 keV through straight and bent glass tubes. A 17 degrees deviation of the electron
O. S. Druj, V. V. Yegorenkov, A. V. Shchagin, V. B. Yuferov   +3 more
doaj  

Organic Spintronics: A Theoretical Investigation of a Graphene-Porphyrin Based Nanodevice

Magnetochemistry, 2020
Spintronics is one of the most exciting applications of graphene-based devices. In this work Density Functional Theory is used to study a nanojunction consisting of two semi-infinite graphene electrodes contacted with an iron-porphyrin (FeP) molecule ...
Elisabetta del Castillo, Fausto Cargnoni, Raffaella Soave, Mario Italo Trioni   +3 more
doaj   +1 more source

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Genotype Specific Photosynthesis x Environment Interactions Captured by Automated Fluorescence Canopy Scans Over Two Fluctuating Growing Seasons

Frontiers in Plant Science, 2019
Photosynthesis reacts dynamic and in different time scales to changing conditions. Light and temperature acclimation balance photosynthetic processes in a complex interplay with the fluctuating environment. However, due to limitations in the measurements
Beat Keller, Shizue Matsubara, Uwe Rascher, Roland Pieruschka, Angelina Steier, Thorsten Kraska, Onno Muller   +6 more
doaj   +1 more source

Waiting time distribution for electron transport in a molecular junction with electron-vibration interaction

, 2016
On the elementary level, electronic current consists of individual electron tunnelling events that are separated by random time intervals. The waiting time distribution is a probability to observe the electron transfer in the detector electrode at time ...
Cuevas J. C., Daniel S. Kosov, Lang I. G., Van Kampen N. G.   +3 more
core   +1 more source

Coordinating Electron Transport Chains to an Electron Donor

Organic Letters, 2015
Two electron transport chains (2 and 3) featuring two fullerenes with different electron acceptor strengths have been synthesized, characterized, and coordinated to a light harvesting/electron donating zinc porphyrin. Electrochemical assays corroborate the redox gradients along the designed electron transport chains, and complementary absorption and ...
Carmen Villegas, Dirk M. Guldi, Maximilian Wolf, Nazario Martín, Nazario Martín, Juan Luis Delgado, Juan Luis Delgado, Damien Joly   +7 more
openaire   +4 more sources

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Alleviation of Nitrogen and Sulfur Deficiency and Enhancement of Photosynthesis in Arabidopsis thaliana by Overexpression of Uroporphyrinogen III Methyltransferase (UPM1)

Frontiers in Plant Science, 2018
Siroheme, an iron-containing tetrapyrrole, is the prosthetic group of nitrite reductase (NiR) and sulfite reductase (SiR); it is synthesized from uroporphyrinogen III, an intermediate of chlorophyll biosynthesis, and is required for nitrogen (N) and ...
Sampurna Garai, Baishnab C. Tripathy
doaj   +1 more source

Temperature dependence of the conductivity of the electronic crystal

, 2004
We study the temperature dependence of the conductivity of the 2D electronic solid. In realistic samples, a domain structure forms in the solid and each domain randomly orients in the absence of the in-plane field.
A. L. Efros, B. I. Shklovskii, D. Yoshioka, N. F. Mott, Shi-Jie Yang, Yue Yu   +5 more
core   +1 more source