Results 101 to 110 of about 1,367,357 (339)

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Role of Second Quinone Binding Site in Proton Pumping by Respiratory Complex I

Frontiers in Chemistry, 2019
Respiratory complex I performs the reduction of quinone (Q) to quinol (QH2) and pumps protons across the membrane. Structural data on complex I have provided spectacular insights into the electron and proton transfer paths, as well as into the long (~30 ...
Outi Haapanen, Amina Djurabekova, Vivek Sharma, Vivek Sharma   +3 more
doaj   +1 more source

Proca Equation for Attosecond Electron Pulses [PDF]

arXiv, 2008
In this paper the heat transport of attosecond electron pulses is investigated. It is shown that attosecond electrons can propagate as thermal waves or diffused as particle conglommerates, Proca equation as type equation for the thermal transport of the attosecond electron pulsem is ...
arxiv  

CD44v, S1PR1, HER3, MET and cancer‐associated amino acid transporters are promising targets for the pancreatic cancers characterized using mAb

FEBS Open Bio, EarlyView.
Novel mAbs could detect cancer‐associated membrane proteins on various type of pancreatic ductal adenocarcinomas (PDAC) by flow cytometry with viable PDAC cells and by immunohistochemistry with PDAC tissues. Results of protein expression were substantiated by mRNA expression by The Cancer Genome Atlas.
Takashi Nakano, Kouki Okita, Shogo Okazaki, Soshi Yoshimoto, Sachiko Masuko, Hideki Yagi, Kazunori Kato, Yoshihisa Tomioka, Kenichi Imai, Yoichi Hamada, Kazue Masuko, Kayoko Shimada‐Takaura, Noriaki Nagai, Hideyuki Saya, Tomio Arai, Toshiyuki Ishiwata, Takashi Masuko   +16 more
wiley   +1 more source

Dynamic Acclimation to High Light in Arabidopsis thaliana Involves Widespread Reengineering of the Leaf Proteome

Frontiers in Plant Science, 2017
Leaves of Arabidopsis thaliana transferred from low to high light increase their capacity for photosynthesis, a process of dynamic acclimation. A mutant, gpt2, lacking a chloroplast glucose-6-phosphate/phosphate translocator, is deficient in its ability ...
Matthew A. E. Miller, Ronan O’Cualain, Julian Selley, David Knight, Mohd F. Karim, Simon J. Hubbard, Giles N. Johnson   +6 more
doaj   +1 more source

Coupled electron and phonon transport in one-dimensional atomic junctions

, 2007
Employing the nonequilibrium Green's function method, we develop a fully quantum mechanical model to study the coupled electron-phonon transport in one-dimensional atomic junctions in the presence of a weak electron-phonon interaction. This model enables
H. Haug, J. T. Lü, Jian-Sheng Wang, L. Kadanoff, L. V. Keldysh, S. Datta   +5 more
core   +1 more source

Purification and characterization of a thermophilic NAD+‐dependent lactate dehydrogenase from Moorella thermoacetica

FEBS Open Bio, EarlyView.
The thermophilic acetogenic model organism Moorella thermoacetica can utilize lactate as substrate. The formation of lactate by reduction of pyruvate is energetically favorable, but the reverse reaction, the oxidation of lactate to pyruvate with NAD+ as electron acceptor is challenging.
Florian P. Rosenbaum, Volker Müller
wiley   +1 more source

Evaluation of synaptotagmin‐1 action models by all‐atom molecular dynamics simulations

FEBS Open Bio, EarlyView.
We used molecular dynamics simulations to test models proposing that synaptotagmin‐1 facilitates membrane fusion by perturbing lipid bilayers, inducing membrane curvature and/or bridging membranes. The simulations show that synaptotagmin‐1 C2‐domains placed near the site of fusion hinder the ability of SNARE complexes to bring the membranes together ...
Josep Rizo, Klaudia Jaczynska, Christian Rosenmund   +2 more
wiley   +1 more source

Two distinct ferredoxins are essential for nitrogen fixation by the iron nitrogenase in Rhodobacter capsulatus

mBio
Nitrogenases are the only enzymes able to fix gaseous nitrogen into bioavailable ammonia and hence are essential for sustaining life. Catalysis by nitrogenases requires both a large amount of ATP and electrons donated by strongly reducing ferredoxins or ...
Holly Addison, Timo Glatter, Georg K. A. Hochberg, Johannes G. Rebelein   +3 more
doaj   +1 more source

Inelastic electron transport in granular arrays

, 2005
Transport properties of granular systems are governed by Coulomb blockade effects caused by the discreteness of the electron charge. We show that, in the limit of vanishing mean level spacing on the grains, the low-temperature behavior of 1d and 2d ...
A. Altland, A. Kamenev, Abrikosov, Aleiner, Altland, Altland, Ambegaokar, Anderson, Andreev, Averin, Belitz, Beloborodov, Beloborodov, Beloborodov, Beloborodov, Berezinskii, Blatter, Chaikin, Chauve, de Gennes, Efetov, Fazio, Feigel’man, Finkelstein, Fisher, Flensberg, Fogler, Furusaki, Gerber, Goeppert, Golubev, Golubev, Golubev, Huberman, J.S. Meyer, Kamenev, Kamenev, Kamenev, Kamenev, Kanzieper, Korshunov, Kosterlitz, L.I. Glazman, Lamacraft, Larkin, Matveev, Meyer, Micah, Mooij, Nagaosa, Nazarov, Panyukov, Parthasarathy, Schön, Sheng, Wang, Zhang   +56 more
core   +1 more source