Results 211 to 220 of about 155,865 (232)

Autophagy activation by urolithin-a derivative UA-36 mitigates Friedreich's ataxia pathologies induced by frataxin deficiency. [PDF]

Mol Biomed
Gong Q, Liu T, Han X, Zhang R, Liu X, Xiong B, Ali T, Huang J, Xie Y, Li S, Yang X.   +10 more
europepmc   +1 more source

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Using Language Representation Learning Approach to Efficiently Identify Protein Complex Categories in Electron Transport Chain

Molecular Informatics, 2020
AbstractWe herein proposed a novel approach based on the language representation learning method to categorize electron complex proteins into 5 types. The idea is stemmed from the the shared characteristics of human language and protein sequence language, thus advanced natural language processing techniques were used for extracting useful features ...
Trinh‐Trung‐Duong Nguyen, Nguyen‐Quoc‐Khanh Le, Quang‐Thai Ho, Dinh‐Van Phan, Yu‐Yen Ou   +4 more
openaire   +2 more sources

Reduced electron transport chain complex I protein abundance and function in Mfn2‐deficient myogenic progenitors lead to oxidative stress and mitochondria swelling

The FASEB Journal, 2021
Abstract Mitochondrial remodeling through fusion and fission is crucial for progenitor cell differentiation but its role in myogenesis is poorly understood. Here, we characterized the function of mitofusin 2 (Mfn2), a mitochondrial outer membrane protein critical for mitochondrial fusion, in muscle progenitor ...
Nanjian Luo, Feng Yue, Zhihao Jia, Jingjuan Chen, Qing Deng, Yongju Zhao, Shihuan Kuang   +6 more
openaire   +2 more sources

Effects of mild hyperhomocysteinemia on electron transport chain complexes, oxidative stress, and protein expression in rat cardiac mitochondria

Molecular and Cellular Biochemistry, 2015
Hyperhomocysteinemia (HHcy) is an independent risk factor of cardiovascular disease, but the mechanisms of tissue injury are poorly understood. In the present study, we investigated the effect of HHcy on rat heart function, activities electron transport chain (ETC) complexes, mitochondrial protein expression, and protein oxidative damage.
Veronika, Timkova, Zuzana, Tatarkova, Jan, Lehotsky, Peter, Racay, Dusan, Dobrota, Peter, Kaplan   +5 more
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Identification of a multi-protein reductive dehalogenase complex in Dehalococcoides mccartyi strain CBDB1 suggests a protein-dependent respiratory electron transport chain obviating quinone involvement.

Environmental microbiology, 2016
Dehalococcoides mccartyi strain CBDB1 is an obligate organohalide-respiring bacterium using only hydrogen as electron donor and halogenated organics as electron acceptor. Here, we studied proteins involved in the respiratory chain under non-denaturing conditions.
Kublik, Anja, Deobald, Darja, Hartwig, Stefanie, Schiffmann, Christian L., Andrades, Adarelys, von Bergen, Martin, Sawers, R. Gary, Adrian, Lorenz   +7 more
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ND15, subunit of the electron transport chain protein-complex I, age-dependently worsens cardiac performance in Drosophila melanogaster

European Heart Journal
Abstract Introduction In the natural aging process of the heart, aside others, mitochondrial dysfunction is an essential driver for the development of reduced cardiac performance. Previous analysis of protein expression levels in cardiomyocytes of aged mice and have found aberrancies in subunits of ...
openaire   +1 more source

Identification of long-lived proteins in the mitochondria reveals increased stability of the electron transport chain

Developmental Cell, 2021
Rafael Arrojo E Drigo, Martin Hetzer, Juliana Capitanio   +2 more
exaly  

Targeting OXPHOS and the electron transport chain in cancer; Molecular and therapeutic implications

Seminars in Cancer Biology, 2022
Simon Lord, John Greene, Ashvina Segaran   +2 more
exaly