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Electron Transport Chain Complex II Regulates Steroid Metabolism
iScience, 2020 Summary: The first steroidogenic enzyme, cytochrome P450-side-chain-cleavage (SCC), requires electron transport chain (ETC) complexes III and IV to initiate steroid metabolic processes for mammalian survival.
Himangshu S. Bose +4 more
doaj +6 more sources
Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II. [PDF]
Blood, 2019 We have previously demonstrated that oxidative phosphorylation is required for the survival of human leukemia stem cells (LSCs) from acute myeloid leukemia (AML) patients.
Jones CL +10 more
europepmc +6 more sources
Stem Cell Research, 2019 The role of mitochondria in the fate determination of hematopoietic stem and progenitor cells (HSPCs) is not solely limited to the switch from glycolysis to oxidative phosphorylation, but also involves alterations in mitochondrial features and properties,
Claudia Morganti +3 more
doaj +9 more sources
Redox Biology, 2020 Generation of mitochondrial reactive oxygen species (ROS) is an important process in triggering cellular necrosis and tissue infarction during ischemia-reperfusion (IR) injury. Ischemia results in accumulation of the metabolite succinate. Rapid oxidation
Alexander S. Milliken +2 more
doaj +6 more sources
Chromophore-Assisted Light Inactivation of Mitochondrial Electron Transport Chain Complex II in Caenorhabditis elegans [PDF]
Scientific Reports, 2016 Mitochondria play critical roles in meeting cellular energy demand, in cell death, and in reactive oxygen species (ROS) and stress signaling. Most Caenorhabditis elegans loss-of-function (lf) mutants in nuclear-encoded components of the respiratory chain
Andrew P. Wojtovich +4 more
semanticscholar +4 more sources
STAR Protocols, 2023 Summary: Mitochondria electron transport chain (ETC) complex II is essential for steroid metabolism. Here, we present a protocol to measure the stability and activity of mitochondria ETC complex II.
Himangshu S. Bose, Nicole E. Doetch
doaj +4 more sources
Rhodoquinone and Complex II of the Electron Transport Chain in Anaerobically Functioning Eukaryotes [PDF]
Journal of Biological Chemistry, 1995 Many anaerobically functioning eukaryotes have an anaerobic energy metabolism in which fumarate is reduced to succinate. This reduction of fumarate is the opposite reaction to succinate oxidation catalyzed by succinate-ubiquinone oxidoreductase, complex ...
Jaap J. van Hellemond +4 more
semanticscholar +7 more sources
Journal of Photochemistry and Photobiology, 2021 In this work, we have explored a new pH sensitive coumarin based ruthenium(II) complex (R1QC) to mimic the role of P680 in donor side of photosystem II in natural photosynthesis.
Anish Babu Athanas, Swarnalatha Kalaiyar
doaj +4 more sources
Why the Flavin Adenine Dinucleotide (FAD) Cofactor Needs To Be Covalently Linked to Complex II of the Electron‐Transport Chain for the Conversion of FADH2 into FAD [PDF]
Chemistry – A European Journal, 2017 A covalently bound flavin cofactor is predominant in the succinate‐ubiquinone oxidoreductase (SQR; Complex II), an essential component of aerobic electron transport, and in the menaquinol‐fumarate oxidoreductase (QFR), the anaerobic counterpart, although
Daniel F. A. R. Dourado +2 more
semanticscholar +7 more sources
A Chinese Hamster Mutant Cell Line with a Defect in the Integral Membrane Protein CII-3 of Complex II of the Mitochondrial Electron Transport Chain [PDF]
Journal of Biological Chemistry, 1995 In this study, a respiration-deficient Chinese hamster cell line with a defect in succinate dehydrogenase activity is shown to result from a single base change in a codon in the coding sequence for the membrane anchor protein CII-3 (also referred to as ...
Frank G. Oostveen +3 more
semanticscholar +6 more sources