Results 41 to 50 of about 151,567 (260)

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Electron transport chain complex II sustains high mitochondrial membrane potential in hematopoietic stem and progenitor cells

Stem Cell Research, 2019
The role of mitochondria in the fate determination of hematopoietic stem and progenitor cells (HSPCs) is not solely limited to the switch from glycolysis to oxidative phosphorylation, but also involves alterations in mitochondrial features and properties,
Claudia Morganti, Massimo Bonora, Kyoko Ito, Keisuke Ito   +3 more
doaj   +1 more source

Janus-Type Dendritic Organoiridium(III) Complex Bearing Hole- and Electron-Transporting Moieties: Synthesis, Luminescence Properties, and OLED Applications [PDF]

Bulletin of the Chemical Society of Japan, 2018
Abstract A novel tris-cyclometalated iridium(III) complex bearing carbazole-based hole-transporting and triarylphosphine oxide-based electron-transporting dendrons was synthesized through a convergent synthetic route, and its facial and meridional isomers were isolated by conventional silica gel chromatography.
Naoki Okamura, Takeshi Maeda, Shigeyuki Yagi   +2 more
openaire   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Dicyclohexylcarbodiimide blocks proton ejection and affects antimycin binding but not electron transport in complex III from yeast mitochondria.

Journal of Biological Chemistry, 1983
Treatment of complex III with dicyclohexyldicarbodiimide (DCCD) either before or after incorporation into liposomes resulted in a loss of electrogenic proton movements; however, only minimal decreases in cytochrome c reductase activity were noted in the liposomes containing DCCD-treated complex III.
L, Clejan, D S, Beattie
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Sordaria macrospora Sterile Mutant pro34 Is Impaired in Respiratory Complex I Assembly

Journal of Fungi, 2022
The formation of fruiting bodies is a highly regulated process that requires the coordinated formation of different cell types. By analyzing developmental mutants, many developmental factors have already been identified.
Andrea Hamann, Heinz D. Osiewacz, Ines Teichert   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Cloflucarban Illuminates Specificity and Context-Dependent Activation of the PINK1–Parkin Pathway by Mitochondrial Complex Inhibition

Biomolecules
The PTEN-induced kinase 1 (PINK1)-Parkin pathway plays a vital role in maintaining a healthy pool of mitochondria in higher eukaryotic cells. While the downstream components of this pathway are well understood, the upstream triggers remain less explored.
Adrian T. Ramirez, Zeyu Liu, Quanbin Xu, Sarah Nowosadtko, Xuedong Liu   +4 more
doaj   +1 more source

MYC—an emerging player in mitochondrial diseases

Frontiers in Cell and Developmental Biology, 2023
The mitochondrion is a major hub of cellular metabolism and involved directly or indirectly in almost all biological processes of the cell. In mitochondrial diseases, compromised respiratory electron transfer and oxidative phosphorylation (OXPHOS) lead ...
Janne Purhonen, Janne Purhonen, Juha Klefström, Juha Klefström, Juha Klefström, Jukka Kallijärvi, Jukka Kallijärvi   +6 more
doaj   +1 more source