Results 21 to 30 of about 151,567 (260)

Anticancer gold(iii)-bisphosphine complex alters the mitochondrial electron transport chain to induce in vivo tumor inhibition

Chemical Science, 2021
Expanding the chemical diversity of metal complexes provides a robust platform to generate functional bioactive reagents.
Jong Hyun Kim, Samuel Ofori, Sean Parkin, Hemendra Vekaria, Patrick G. Sullivan, Samuel G. Awuah   +5 more
openaire   +3 more sources

Organization of the Respiratory Supercomplexes in Cells with Defective Complex III: Structural Features and Metabolic Consequences

Life, 2021
The mitochondrial respiratory chain encompasses four oligomeric enzymatic complexes (complex I, II, III and IV) which, together with the redox carrier ubiquinone and cytochrome c, catalyze electron transport coupled to proton extrusion from the inner ...
Michela Rugolo, Claudia Zanna, Anna Maria Ghelli   +2 more
doaj   +1 more source

Mitochondrial electron transport chain complex III sustains hepatitis E virus replication and represents an antiviral target [PDF]

The FASEB Journal, 2018
ABSTRACT Hepatitis E virus (HEV) infection has emerged as a global health problem. However, no approved medication is available, and the infection biology remains largely elusive. Electron transport chain (ETC), a key component of the mitochondria, is the main site that produces ATP and reactive oxygen species ...
Qu, Changbo, Zhang, Shaoshi, Wang, Wenshi, Li, Li, Wang, Yongyi, Mulder, Marieke, Shokrollahi, Sam, Mohamad Saifudin, Hakim, Raat, Harold, Peppelenbosch, Maikel, Pan, Qiuwei   +10 more
openaire   +3 more sources

The CoQH2/CoQ Ratio Serves as a Sensor of Respiratory Chain Efficiency

Cell Reports, 2016
Electrons feed into the mitochondrial electron transport chain (mETC) from NAD- or FAD-dependent enzymes. A shift from glucose to fatty acids increases electron flux through FAD, which can saturate the oxidation capacity of the dedicated coenzyme Q (CoQ)
Adela Guarás, Ester Perales-Clemente, Enrique Calvo, Rebeca Acín-Pérez, Marta Loureiro-Lopez, Claire Pujol, Isabel Martínez-Carrascoso, Estefanía Nuñez, Fernando García-Marqués, María Angeles Rodríguez-Hernández, Ana Cortés, Francisca Diaz, Acisclo Pérez-Martos, Carlos T. Moraes, Patricio Fernández-Silva, Aleksandra Trifunovic, Plácido Navas, Jesús Vazquez, Jose A. Enríquez   +18 more
doaj   +1 more source

Is impaired energy production a novel insight into the pathogenesis of pyridoxine-dependent epilepsy due to biallelic variants in ALDH7A1?

PLoS ONE, 2021
BackgroundPyridoxine-dependent epilepsy (PDE) is due to biallelic variants in ALDH7A1 (PDE-ALDH7A1). ALDH7A1 encodes α-aminoadipic semialdehyde dehydrogenase in lysine catabolism.
Anastasia Minenkova, Erwin E W Jansen, Jessie Cameron, Rob Barto, Thomas Hurd, Lauren MacNeil, Gajja S Salomons, Saadet Mercimek-Andrews   +7 more
doaj   +1 more source

Identifying Site-Specific Superoxide and Hydrogen Peroxide Production Rates From the Mitochondrial Electron Transport System Using a Computational Strategy

Function, 2021
Mitochondrial reactive oxygen species (ROS) play important roles in cellular signaling; however, certain pathological conditions such as ischemia/reperfusion (I/R) injury disrupt ROS homeostasis and contribute to cell death.
Quynh V Duong, Yan Levitsky, Maria J Dessinger, Jasiel O Strubbe-Rivera, Jason N Bazil   +4 more
doaj   +1 more source

Complex III deficiency due to an in-frame MT-CYB deletion presenting as ketotic hypoglycemia and lactic acidosis

Molecular Genetics and Metabolism Reports, 2015
Complex III deficiency due to a MT-CYB mutation has been reported in patients with myopathy. Here, we describe a 15-year-old boy who presented with metabolic acidosis, ketotic hypoglycemia and carnitine deficiency.
Mari Mori, Jennifer Goldstein, Sarah P. Young, Edward H. Bossen, John Shoffner, Dwight D. Koeberl   +5 more
doaj   +1 more source

Bistability of mitochondrial respiration underlies paradoxical reactive oxygen species generation induced by anoxia.

PLoS Computational Biology, 2009
Increased production of reactive oxygen species (ROS) in mitochondria underlies major systemic diseases, and this clinical problem stimulates a great scientific interest in the mechanism of ROS generation. However, the mechanism of hypoxia-induced change
Vitaly A Selivanov, Tatyana V Votyakova, Jennifer A Zeak, Massimo Trucco, Josep Roca, Marta Cascante   +5 more
doaj   +1 more source

Methylene Blue Bridges the Inhibition and Produces Unusual Respiratory Changes in Complex III-Inhibited Mitochondria. Studies on Rats, Mice and Guinea Pigs

Antioxidants, 2021
Methylene blue (MB) is used in human therapy in various pathological conditions. Its effects in neurodegenerative disease models are promising. MB acts on multiple cellular targets and mechanisms, but many of its potential beneficial effects are ascribed
Gergely Sváb, Márton Kokas, Ildikó Sipos, Attila Ambrus, László Tretter   +4 more
doaj   +1 more source

The outer membrane protein Omp35 affects the reduction of Fe(III), nitrate, and fumarate by Shewanella oneidensis MR-1

BMC Microbiology, 2004
Background Shewanella oneidensis MR-1 uses several electron acceptors to support anaerobic respiration including insoluble species such as iron(III) and manganese(IV) oxides, and soluble species such as nitrate, fumarate, dimethylsulfoxide and many ...
Myers Charles R, Maier Tamara M
doaj   +1 more source