Results 11 to 20 of about 151,567 (260)

Phospholipid requirements for the reconstitution of complex-III vesicles exhibiting controlled electron transport [PDF]

Biochemical Journal, 1981
Phospholipid requirements for the reconstitution of Complex-III vesicles exhibiting respiratory control (electron-transport control) were studied. Vesicles prepared from pure phosphatidylethanolamine gave maximal control ratios. Phosphatidylcholine alone did not support respiratory control, although these vesicles were capable of maintaining stable K ...
B D, Nelson, S, Fleischer
openaire   +2 more sources

Ascorbate Biosynthesis in Mitochondria Is Linked to the Electron Transport Chain between Complexes III and IV [PDF]

Plant Physiology, 2000
Abstract Ascorbic acid is synthesized from galactono-γ-lactone (GL) in plant tissues. An improved extraction procedure involving ammonium sulfate precipitation of membrane proteins from crude leaf homogenates yielded a simple, quick method for determining tissue activities of galactono-γ-lactone dehydrogenase (GLDH).
Bartoli, Carlos Guillermo, Pastori, Gabriela M., Foyer, Christine H.   +2 more
openaire   +3 more sources

Divergent features of the coenzyme Q:cytochrome c oxidoreductase complex in Toxoplasma gondii parasites.

PLoS Pathogens, 2021
The mitochondrion is critical for the survival of apicomplexan parasites. Several major anti-parasitic drugs, such as atovaquone and endochin-like quinolones, act through inhibition of the mitochondrial electron transport chain at the coenzyme Q ...
Jenni A Hayward, Esther Rajendran, Soraya M Zwahlen, Pierre Faou, Giel G van Dooren   +4 more
doaj   +1 more source

APOE expression and secretion are modulated by mitochondrial dysfunction

eLife, 2023
Mitochondria influence cellular function through both cell-autonomous and non-cell autonomous mechanisms, such as production of paracrine and endocrine factors.
Meghan E Wynne, Oluwaseun Ogunbona, Alicia R Lane, Avanti Gokhale, Stephanie A Zlatic, Chongchong Xu, Zhexing Wen, Duc M Duong, Sruti Rayaprolu, Anna Ivanova, Eric A Ortlund, Eric B Dammer, Nicholas T Seyfried, Blaine R Roberts, Amanda Crocker, Vinit Shanbhag, Michael Petris, Nanami Senoo, Selvaraju Kandasamy, Steven Michael Claypool, Antoni Barrientos, Aliza Wingo, Thomas S Wingo, Srikant Rangaraju, Allan I Levey, Erica Werner, Victor Faundez   +26 more
doaj   +1 more source

A Biophysical Model of the Mitochondrial Respiratory System and Oxidative Phosphorylation. [PDF]

PLoS Computational Biology, 2005
A computational model for the mitochondrial respiratory chain that appropriately balances mass, charge, and free energy transduction is introduced and analyzed based on a previously published set of data measured on isolated cardiac mitochondria.
Daniel A Beard
doaj   +2 more sources

Mitochondrial reactive oxygen species modify extracellular vesicles secretion rate

FASEB BioAdvances, 2023
Extracellular vesicle (EV) secretion rate is stimulated by hypoxia that causes increased reactive oxygen species (ROS) production by the mitochondrial electron transport chain (ETC) and hypoxia‐induced factor (HIF)‐1 signaling; however, their ...
Mikkel Ø. Nørgård, Philip M. Lund, Nazmie Kalisi, Thomas L. Andresen, Jannik B. Larsen, Stefan Vogel, Per Svenningsen   +6 more
doaj   +1 more source

Mitochondria in human neutrophils mediate killing of Staphylococcus aureus

Redox Biology, 2022
Background: Neutrophils play a role in innate immunity and are critical for clearance of Staphylococcus aureus. Current understanding of neutrophil bactericidal effects is that NADPH oxidase produces reactive oxygen species (ROS), mediating bacterial ...
Kimberly J. Dunham-Snary, Bas GJ. Surewaard, Jeffrey D. Mewburn, Rachel ET. Bentley, Ashley Y. Martin, Oliver Jones, Ruaa Al-Qazazi, Patricia AD. Lima, Paul Kubes, Stephen L. Archer   +9 more
doaj   +1 more source

Mitochondrial Function and Parkinson’s Disease: From the Perspective of the Electron Transport Chain

Frontiers in Molecular Neuroscience, 2021
Parkinson’s disease (PD) is known as a mitochondrial disease. Some even regarded it specifically as a disorder of the complex I of the electron transport chain (ETC).
Jeng-Lin Li, Jeng-Lin Li, Tai-Yi Lin, Po-Lin Chen, Ting-Ni Guo, Shu-Yi Huang, Chun-Hong Chen, Chin-Hsien Lin, Chin-Hsien Lin, Chih-Chiang Chan   +9 more
doaj   +1 more source

Mitochondrial Lipid Peroxidation Is Responsible for Ferroptosis

Cells, 2023
Ferroptosis induced by erastin (an inhibitor of cystine transport) and butionine sulfoximine (an inhibitor of glutathione biosynthesis) was prevented by the mitochondria-targeted antioxidants SkQ1 and MitoTEMPO.
Konstantin G. Lyamzaev, Alisa A. Panteleeva, Ruben A. Simonyan, Armine V. Avetisyan, Boris V. Chernyak   +4 more
doaj   +1 more source

Reactive oxygen species production by forward and reverse electron fluxes in the mitochondrial respiratory chain.

PLoS Computational Biology, 2011
Reactive oxygen species (ROS) produced in the mitochondrial respiratory chain (RC) are primary signals that modulate cellular adaptation to environment, and are also destructive factors that damage cells under the conditions of hypoxia/reoxygenation ...
Vitaly A Selivanov, Tatyana V Votyakova, Violetta N Pivtoraiko, Jennifer Zeak, Tatiana Sukhomlin, Massimo Trucco, Josep Roca, Marta Cascante   +7 more
doaj   +1 more source