Results 201 to 210 of about 95,409 (213)

POU4F2/Brn-3b is Essential for Spermatogenesis and its Disruption is Linked to Male Infertility in Mice and Humans

Budhram-Mahadeo V, Phillips N, Sironen A, Holt M, Riera-Escamilla A, Conrad D.   +5 more
europepmc   +1 more source

COX4I1 Controls Mitochondrial Electron Transport Chain Complex IV Assembly and Leukemia Progression in Acute Myeloid Leukemia

Blood, 2023
Aberrant cellular signaling plays a pivotal role in the pathogenesis of acute myeloid leukemia (AML). Identifying key signaling components and their dependencies is crucial for advancing AML therapy. Here, we conducted a focused CRISPR library screen targeting 427 cell signaling-related genes with 3,416 sgRNAs (8 sgRNAs per gene) in the
Leisi Zhang, Mingli Li, Anthony KN Chan, Qiao Liu, Hyunjun Kang, Sheela Pangeni Pokharel, Nicole Mattson, Priyanka Singh, Lu Yang, Chun-Wei David Chen   +9 more
openaire   +2 more sources

Involvement of water in electron transport in complexes III and IV of the mitochondrial electron transport chain

Biochemical and Biophysical Research Communications, 1966
In this communication we present some preliminary findings on the “cross-over points” which we observed when isolated electron transport complexes III and IV from beef heart mitochondria were studied in 90% glycerol. Three considerations led us to study electron transport in a medium of low water activity: 1) Such studies might allow the resolution of ...
H, Baum, J S, Rieske
openaire   +3 more sources

Understanding molecular biology of codon usage in mitochondrial complex IV genes of electron transport system: Relevance to mitochondrial diseases

Journal of Cellular Physiology, 2018
AbstractThe mitochondrial cytochrome oxidase (CO) genes are involved in complex IV of the electron transport system, and dysfunction of CO genes leads to several diseases. However, no work has been reported on the codon usage pattern of these genes. We used bioinformatic methods to analyze the compositional properties and the codon usage pattern of the
Arif Uddin, Tarikul Huda Mazumder, Supriyo Chakraborty   +2 more
openaire   +3 more sources

Abstract 57: Erythropoietin Selectively Preserves Electron Transport Complex IV Activity During Resuscitation from Cardiac Arrest

Circulation, 2011
Introduction: We have previously documented in a rat model of VF and closed-chest resuscitation that administration of erythropoietin (EPO) preserves left ventricular distensibility - yielding hemodynamically more effective CPR - and attenuates post-resuscitation myocardial dysfunction ...
Jeejabai Radhakrishnan, Hawnyeu M Moy, Raúl J Gazmuri   +2 more
openaire   +2 more sources

Bezafibrate induced increase in mitochondrial electron transport chain complex IV activity in human astrocytoma cells: Implications for mitochondrial cytopathies and neurodegenerative diseases

BioFactors, 2010
AbstractMitochondrial encephalomyopathies resulting from electron transport chain (ETC) dysfunction can present with a wide spectrum of clinical manifestations having significant neuropathology and a progressive nature. Despite advances in diagnosis of ETC disorders, treatment still remains inadequate.
Nicola, Ioannou, Iain P, Hargreaves, George, Allen, Kate, Duberley, John M, Land, Simon J R, Heales   +5 more
openaire   +3 more sources

l‐DOPA Inhibits Complex IV of the Electron Transport Chain in Catecholamine‐Rich Human Neuroblastoma NB69 Cells

Journal of Neurochemistry, 1995
Abstract: l‐3,4‐Dihydroxyphenylalanine (l‐DOPA) is toxic for human neuroblastoma cells NB69 and its toxicity is related to several mechanisms including quinone formation and enhanced production of free radicals related to the metabolism of dopamine via monoamine oxidase type B.
B, Pardo, M A, Mena, J G, de Yébenes
openaire   +3 more sources

Loss of hepatic cytochrome aa3 during chronic valproate treatment: dissociation of proton pumping and electron transport in Complex IV

Biochemical Society Transactions, 1991
S, Ponchaut, J P, Draye, F, Van Hoof, K, Veitch   +3 more
openaire   +3 more sources

Diffuse Cortical Gliosis Is Associated with Decreased Mitochondrial Electron Transport Chain Complex IV Activity in Epileptogenic Brain Resected from Children with Intractable Epilepsy (PD3.003)

Neurology, 2012
M. Miles, L. Miles, F. Mangano, P. Horn, H. Greiner, J. Leach, K. H. Lee, T. DeGrauw, C. Hoppel   +8 more
openaire   +2 more sources