Results 141 to 150 of about 2,528,291 (336)

m6A-methylase METTL3 promotes retinal angiogenesis through modulation of metabolic reprogramming in RPE cells

Journal of Neuroinflammation
Retinal neovascularization (RNV) disease is one of the leading causes of blindness, yet the molecular underpinnings of this condition are not well understood.
Qian Zhou, Xianyang Liu, Huiping Lu, Na Li, Jiayu Meng, Jiaxing Huang, Zhi Zhang, Jiangyi Liu, Wei Fan, Wanqian Li, Xingran Li, Xiaoyan Liu, Hangjia Zuo, Peizeng Yang, Shengping Hou   +14 more
doaj   +1 more source

Bulgarian Folk Songs in a Digital Library [PDF]

, 2011
The paper presents the main results of an ongoing project aimed at the development of technologies for digitization of Bulgarian folk music and building a heterogeneous digital library with Bulgarian folk songs presented with their music, notes and text.
Kirov, Nikolay, Peycheva, Lozanka
core  

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

Advanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong, Aima Huang, Ziqing Zhao, Bikai Lai, Xin Pan, Huiyu Yang, Xiaohan Xu, Tianwei Wang, Fangchen Zhao, Zhimin Zhang, Yongbo Xue, Guanjun Deng, Wenbin Deng, Jianwei Chen   +13 more
wiley   +1 more source

Presentation of Fuzzy Model to Evaluate Amount of Preparedness to Adopt Information Management System in Organization (case study: Zahedan Municipality)

Iranian Journal of Information Processing & Management, 2019
The main goal of this study is to present fuzzy logic-based method in order to evaluate preparedness of organizations in adopting information management system. As a case study, this model was implemented in Zahedan Municipality.
Ahmad Khajeh Ahmadi
doaj  

Electronic Complaint Management System for Municipal Corporation

Communications on Applied Electronics, 2015
Sajidabhanu S, B. Regina, B. Sudhir
openaire   +1 more source

Index of functionality of municipal electronic portals: access to health information

, 2021
Este estudio buscó investigar en que medida las informaciones en salud ha sido puesto a disposición de la población y el grado de funcionalidad de las webs en cuanto al acceso a las páginas electrónicas oficiales de los municipios que albergan los Departamentos Regionales de Salud (DRS) del Estado de São Paulo.
Moimaz, Suzely Adas Saliba, Nascimento, Carolina Carvalho Menez Pinto, Saliba, Tânia Adas, Herval, Ana Cláudia Festucci de, Zacharias, Fabiana Costa Machado, Arcêncio, Ricardo Alexandre, Garbin, Cléa Adas Saliba   +6 more
openaire   +1 more source

Ultrasound Modulation of Visual Circuits in Mice Independent of Auditory Confound

Advanced Science, EarlyView.
In this study, Qiu et al. found that low‐intensity ultrasound can directly activate sparse ultrasound‐sensitive neurons (UNs) in the primary visual cortex (V1) of deafened mice. The proportion of these sparse UNs is pressure‐dependent. Furthermore, ultrasound modulates visual circuitry with distinct excitatory and inhibitory effects.
Jiaru He, Jiejun Zhu, Xinxin Wang, Zihao Chen, Jin Yang, Zhen Yuan, Hongzhi Xu, Lei Sun, Zhihai Qiu   +8 more
wiley   +1 more source

The Implications of Densification Policies for Greater Resistencia (Argentina): an Assessment of Recent Experience [PDF]

, 2014
. Since 2001, Resistencia City Council has been promoting growth in building height by steering development towards built-up areas in central districts that already have complete infrastructure, through the implementation of the Ordinance 5403/01 - high ...
Schneider, V. (Valeria)
core  

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source