Results 81 to 90 of about 66,716 (273)

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

VERIFIKASI GEOMETRI DAN INDEKS GAMMA PADA PESAWAT LINAC TIPE CLINAC CX TERINTEGRASI EPID DI RS UNIVERSITAS ANDALAS VERIFIKASI GEOMETRI DAN INDEKS GAMMA PADA PESAWAT LINAC TIPE CLINAC CX TERINTEGRASI EPID DI RS UNIVERSITAS ANDALAS [PDF]

Wahana Fisika: Jurnal Penelitian Fisika dan Terapannya, 2019
Telah dilakukan verifikasi geometri dan indeks gamma pada pesawat Linac tipe Clinac CX yang terintegrasi Electronic Portal Imaging Device (EPID) di Rumah Sakit Universitas Andalas. Verifikasi bertujuan untuk mengetahui kondisi pesawat Linac.
Dian Milvita, Bagus Sidik Waskito Hadi
doaj   +1 more source

Evaluation of a Scintillating Plastic Optical Fiber Device for Measuring kV-Cone Beam Computed Tomography Dose

Sensors, 2023
Background: Justification of imaging procedures such as cone beam computed tomography (CBCT) in radiotherapy makes no doubt. However, the CBCT composite dose is rarely reported or optimized, even though the repeated CBCT cumulative dose can be up to 3 ...
Christian Popotte, Romain Letellier, Didier Paul, Alexandre Waltener, Nicolas Guillochon, Mélodie Munier, Paul Retif   +6 more
doaj   +1 more source

Dosimetry with a fluoroscopic electronic portal imaging device [PDF]

Medical Physics, 2000
Techniques for dosimetric verification of radiotherapy treatments using a CCD camera based fluoroscopic electronic portal imaging device (EPID) are described. The dosimetric characteristics of the EPID were investigated and a method was developed to derive portal dose images (PDIs) from measured EPID images.
openaire   +1 more source

The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis

Advanced Science, EarlyView.
SLC39A13/ZIP13, a newly discovered intracellular iron transporter, delivers iron to the ER/Golgi to catalyze procollagen hydroxylation during collagen maturation. Here, we systematically characterize the cell type‐specific functions of ZIP13 across distinct hepatic cell populations, and identify hepatic stellate cell‐specific ZIP13 as a promising and ...
Shanshan Guo, Yalin Wang, Binyu Lu, Yu Zhang, David M. Frazer, Bing Zhou   +5 more
wiley   +1 more source

Patient-specific intensity modulated radiotherapy quality assurance using an electronic portal imaging device

Nucleus, 2016
modern clinical electron linear accelerator was commissioned at the Department of Radiotherapy in the Oncology and Radiobiology Institute. The use of electronic portal image device (EPID) for patient-specific intensity modulated radiotherapy (IMRT ...
Eduardo F. Larrinaga Cortina, David N. Alonso Fernández   +1 more
doaj  

USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer

Advanced Science, EarlyView.
USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen, Ling Wang, Hongmei Fan, Lisheng Li, Lingyu Zhang, Ruoxin Li, Fang Liu, Fuli Wen, Yunbin Ye, Chuanzhong Huang   +9 more
wiley   +1 more source

A feasibility study for the provision of electronic healthcare tools and services in areas of Greece, Cyprus and Italy [PDF]

, 2011
Background: Through this paper, we present the initial steps for the creation of an integrated platform for the provision of a series of eHealth tools and services to both citizens and travelers in isolated areas of thesoutheast Mediterranean, and on ...
Androulidakis, Aggelos, Bracale, Umberto, Konnis, Georgios, Koutsouris, Dimitrios, Kyriacou, Efthyvoulos, Mougiakakou, Stavroula G., Papadopoulos, Homer, Pattichis, Constantinos S., Pecchia, Leandro, Perakis, Kostas, Tranfaglia, Riccardo   +10 more
core   +7 more sources

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

Intelligent Soft Opto‐Magnetic Robot for Minimally Invasive Interventional Therapy

Advanced Science, EarlyView.
An intelligent soft opto‐magnetic (iSOM) robot is developed that integrates remote magnetic actuation, skin‐mimic tactile perception, and photothermal ablation in a near‐millimeter‐scale design. It enables precise intraluminal navigation and localized ablation while providing real‐time optical feedback to support safe and accurate minimally invasive ...
Jingjing Guo, Xiaoyan Guo, Jian Wei, Miaowen Jiang, Qifa Su, Xian Xia, Zhuozhou Li, Rong Cai, Jianguo Ma, Bo Fu, Ming Li, Jing Zhong, Lijun Xu, Xunming Ji   +13 more
wiley   +1 more source