Results 171 to 180 of about 43,957 (340)

Ligand‐Level Chemical Activation: Coordination with Benefits

European Journal of Inorganic Chemistry, EarlyView.
While often perceived as a liability, ligand‐based reactivity in carefully designed settings becomes a powerful synthetic tool. The key to streamlined processes overriding classical ionic reactivity is the selective electron redistribution induced by metal coordination. This enables storage of electrons and protons or incorporation of functional groups
Oscar Charpentier, Agnideep Das, Marine Desage‐El Murr   +2 more
wiley   +1 more source

Nickel-Catalyzed α‑Arylation and Alkenylation of α‑Trifluoromethyl Amines via 1,2-HAT Assisted by DMSO. [PDF]

JACS Au
Bilal M, Fatima K, Wu YJ, Guan YQ, Liang YF.   +4 more
europepmc   +1 more source

Mechanistic Studies of Cytochrome P450 3A4 Time-Dependent Inhibition Using Two Cysteine-Targeting Electrophiles [PDF]

, 2020
John Barr, Zhican Wang, Xiaoshan Min, Henry J. Wienkers, Brooke M. Rock, Dan A. Rock, Larry C. Wienkers   +6 more
openalex   +1 more source

Push–Pull Ynamines and Push–Pull Ynamides: Synthesis, Structure, Reactivity, and Application

European Journal of Organic Chemistry, EarlyView.
Push–pull ynamines and push–pull ynamides, which carry an EWG and an amino or amido group as EDG, are highly interesting classes of EDG‐EWG alkynes that have been intensively studied due to their exceptional reactivity. In this review, the synthesis, structure, reactivity, and application of push–pull ynamines, push–pull ynecarbamates, push–pull ...
Hans‐Joachim Gais
wiley   +1 more source

Iron Catalyzed Aryl-Aryl Kumada Cross-Coupling: A Mechanistic and Computational Investigation. [PDF]

Angew Chem Int Ed Engl
Panda J, Gimeno M, Gogoi A, Chen Z, Garhwal S, Levy L, Kaushansky A, Fridman N, Briggs-Pritchard J, Gershoni-Poranne R, Neidig ML, de Ruiter G.   +11 more
europepmc   +1 more source

1,1‐Disubstituted Vinylbromides: Versatile Building Blocks for the Synthesis of Nitrogen‐Containing Heterocycles

European Journal of Organic Chemistry, EarlyView.
1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer, Jun Fang, Chonghuo Liu, Guillaume Lefèvre, Gérard Guillamot, Phannarath Phansavath, Virginie Ratovelomanana‐Vidal   +6 more
wiley   +1 more source

Copper-Catalyzed Enantioconvergent Nucleophilic Fluorination of Alkyl Electrophiles to Generate α-Fluoroamides. [PDF]

J Am Chem Soc
Wang ZY, Fu GC.
europepmc   +1 more source

PART I. ELECTROPHILE STRUCTURE AS A FACTOR IN ALKYLATIONS OF CAMPHOR DERIVATIZED GLYCINATES. PART II. PUMMERER REACTIONS OF S-OXIDES OF 1,3-OXATHIOLAN-5-ONES AND 1,3-THIAZOLIDIN-4-ONES.

, 1986
Randall K. Leavitt
openalex   +1 more source

Design and Synthesis of Lactose‐Derived Ligands and Their Application in Asymmetric Friedel–Crafts Alkylation

European Journal of Organic Chemistry, EarlyView.
This work describes the synthesis of lactose‐ and glucose‐derived chiral ligands and their application in the catalytic enantioselective Friedel–Crafts alkylation of indole with a series of trans‐β‐nitrostyrenes. The optimal ligand was an acetate protected, lactose‐derived pyridyl imine and its zinc complex afforded ees up to 93% and yields up to 93 ...
Sandra Bulawa, Julia Bruno‐Colmenarez, Patrick J. Guiry   +2 more
wiley   +1 more source

Stereocontrolled Synthesis of Polysubstituted Housanes via <i>gem</i>-Bismetalated Cyclopropanes. [PDF]

J Am Chem Soc
Orbach N, Suresh R, Marek I.
europepmc   +1 more source