Results 171 to 180 of about 22,971 (281)

Multiscale Effects of Environmentally Relevant Mixtures Containing Two Estrogenic Endocrine Disruptors, Chlordecone and Propylparaben, in Hydra vulgaris Pallas, 1766

Environmental Toxicology, EarlyView.
ABSTRACT This study investigates the chronic effects of chlordecone (CLD) and propylparaben (PP), two pro‐estrogenic endocrine disruptors, on Hydra vulgaris Pallas, 1766 using a multiscale approach over a 14‐day exposure period. Environmentally relevant concentrations of CLD (0.5, 5, 20 μg L−1) and PP (0.01, 0.05, 0.40 μg L−1) were tested individually ...
Magali Domallain, Romain Colpaert, Xavier Moreau, Laetitia De Jong, Karim Benbrahim, Raphael Coatmeur, Valérie Pique, Maxime Robin, Pierre‐Henri Villard   +8 more
wiley   +1 more source

Diorganotelluride···N Chalcogen Bonds: Analysis and Tuning of Two σ‐Holes

Zeitschrift für anorganische und allgemeine Chemie, EarlyView.
Two new chalcogen bond aggregates were analyzed using single crystal X‐ray diffraction: an oligomeric ChB aggregate between bis(pentafluorophenyl) telluride and DABCO, and a monoadduct between (pentafluorophenyl)(phenyl) telluride and quinuclidine. In addition to some of the shortest intermolecular Te···N contacts reported, these structures provide ...
Thokozire Sweetland, Arnold Ressel, Ruimin Wang, Paul Erik Schneider, Ulli Englert, Carsten Strohmann   +5 more
wiley   +1 more source

Deprotonation and Alkylation of Weakly Acidic C(sp³)─H Bonds Through In Situ Generation of a Strong Hydride Base From 1,1,3,3-Tetramethyldisiloxane and Potassium tert-Butoxide. [PDF]

Angew Chem Int Ed Engl
Onge PS, White B, Yao H, Dudding T, Newman SG.   +4 more
europepmc   +1 more source

Hydrothermal origin of metabolic phosphorylation

The FEBS Journal, EarlyView.
Serpentinizing hydrothermal vents are candidate sites for biochemical origins. They generate extremely reducing conditions, depositing phosphite (HPO32−) and transition metals, including palladium, in the native (zero‐valent) state. Schlikker et al.
Manon L. Schlikker, Nadja K. Hoffmann, Sabine Metzger, Jorge Moral‐Pombo, Harun Tüysüz, William F. Martin   +5 more
wiley   +1 more source

Brief encounters and lasting impressions—How target protein half‐life affects reactive metabolite signaling

The FEBS Journal, EarlyView.
Lipid‐derived reactive electrophile molecules (REMs) are generated from fatty acids through lipoxygenase or cyclooxygenase‐assisted catalysis, or free radical‐induced lipid peroxidation events. REMs so‐produced covalently modify nearby protein‐cysteines, and in the case of ‘first responder’ proteins, can trigger gain‐of‐function signaling with context ...
Marcus J. C. Long, Lorna Birkby, Yimon Aye   +2 more
wiley   +1 more source

Excited-State Intramolecular Proton Transfer Enables Self-Reporting Fluorescent Photoaffinity Labeling in Live Cells. [PDF]

J Am Chem Soc
Kozoriz K, Murale DP, Hong SC, Hong KT, Haque MM, Kim YK, Lee JS.   +6 more
europepmc   +1 more source

Nitroalkylation Mediated by Nitro‐Fatty Acids Is Involved in Key Physiological Processes During Arabidopsis thaliana Development

Plant, Cell &Environment, EarlyView.
ABSTRACT Nitro‐fatty acids (NO2‐FAs) are potent electrophiles that react with nucleophilic residues in proteins (cysteines, histidines and lysines) via a process known as nitroalkylation. This reversible post‐translational modification (PTM) functions as a selective signalling mechanism by modulating the structure, transport, and catalysis of target ...
Lorena Aranda‐Caño, Raquel Valderrama, Mounira Chaki, Juan Carlos Begara‐Morales, José Rafael Pedrajas, Manuel Melguizo, Matín Moret, Aureliano Bombarely, Francisco Luque, Juan Bautista Barroso   +9 more
wiley   +1 more source

Synthesis of Arylpiperazine-Based CNS Ligands: Batch Disconnections and Their Continuous-Flow Implementation. [PDF]

Molecules
Jeong D, Han JM, Lee JH, Oh IY, Cho YR, Kwon YJ.   +5 more
europepmc   +1 more source

Selective photo labeling of tryptophan in N‐acetyl‐L‐tryptophan ethyl ester and peptide WWCNDGR with a diaryl nitrenium ion

Photochemistry and Photobiology, EarlyView.
Visible light photolysis of a N‐(N,N‐diarylaminopyridinium) salt allows for covalent modification of a peptide. Mass spectrometry demonstrates that this procedure selectively labels tryptophan residues. Laser flash photolysis experiments show that bond formation occurs via a diarylnitrenium ion intermediate.
Edward S. Chinn, Yue Li, Abigail M. Joyce, Daniel E. Falvey   +3 more
wiley   +1 more source

A Genetically Encoded Electrophilic Lysine Derivative Enables Sortase-Mediated Assembly of SUMO Activity-Based Probes. [PDF]

J Am Chem Soc
Wanka V, Kvasha D, Cigler M, Heymes-Krauskopf K, Ruckgaber P, Heider A, Fottner M, Groll M, Lang K.   +8 more
europepmc   +1 more source