Results 91 to 100 of about 6,006 (253)

Evolution and Immune Function of Fish Lectins [PDF]

open access: yes, 2016
Lectins are sugar-binding proteins widely distributed among animals, plants, and microbial taxon, involved in diverse biological processes. In both invertebrates and vertebrates, they play key roles in nonself recognition and immune responses, such as ...
Ahmad   +95 more
core   +1 more source

Identification of Cannabidiolic and Cannabigerolic Acids as MTDL AChE, BuChE, and BACE‐1 Inhibitors Against Alzheimer's Disease by In Silico, In Vitro, and In Vivo Studies

open access: yesPhytotherapy Research, Volume 39, Issue 1, Page 233-245, January 2025.
ABSTRACT Cannabidiolic (CBDA) and cannabigerolic (CBGA) acids are naturally occurring compounds from Cannabis sativa plant, previously identified by us as dual PPARα/γ agonists. Since the development of multitarget‐directed ligands (MTDL) represents a valuable strategy to alleviate and slow down the progression of multifactorial diseases, we evaluated ...
Rosa Maria Vitale   +16 more
wiley   +1 more source

Phylogenetic revision of Gymnotidae (Teleostei: Gymnotiformes), with descriptions of six subgenera.

open access: yesPLoS ONE, 2019
The diversity of gymnotid electric fishes has been intensely studied over the past 25 years, with 35 species named since 1994, compared to 11 species in the previous 236 years.
Jack M Craig   +3 more
doaj   +1 more source

Detection Limit of Carbamate Pesticides Biosensors Based Enzyme Acetylcholinesterase and Cholin Oxidase on Platinum Electrode [PDF]

open access: yes, 2011
The presence of carbamate pesticides in environmental and food poses a potentialhazard to human health and there is a growing interest in their rapid and accurate determinationfor food safety and environmental monitoring.
Mashuni, M. (Mashuni)
core  

The fish fauna of the Iwokrama Forest [PDF]

open access: yes, 2005
Fishes were collected from the rivers in and around the Iwokrama Forest during January-February and November-December 1997. Four hundred species of fish were recorded from forty families in ten orders.
Arjoon, D   +5 more
core   +1 more source

Why is binding of a divalent metal cation to a structural motif containing four carboxylate residues not accompanied by a conformational change?

open access: yesProtein Science, Volume 33, Issue 12, December 2024.
Abstract We earlier showed that Torpedo californica acetylcholinesterase (AChE) contains a cluster of four conserved aspartates that can strongly bind divalent cations, which we named the 4D motif. Binding of the divalent metal cations greatly increases its thermal stability.
Sofya Lushchekina   +6 more
wiley   +1 more source

Evaluating Blood–Brain Barrier Permeability, Cytotoxicity, and Activity of Potential Acetylcholinesterase Inhibitors: In Vitro and In Silico Study

open access: yesPharmacology Research &Perspectives, Volume 12, Issue 6, December 2024.
ABSTRACT Acetylcholinesterase inhibitors (AChEIs) remain the first‐line treatment for Alzheimer's disease. However, these drugs are largely symptomatic and often associated with adverse effects. This study aimed to evaluate novel pharmacophores for their in vitro AChEI activity, blood–brain barrier (BBB) permeability, and cytotoxic potential ...
L. M. Maboko   +5 more
wiley   +1 more source

Innovative pathological network‐based multitarget approaches for Alzheimer's disease treatment

open access: yesMedicinal Research Reviews, Volume 44, Issue 6, Page 2367-2419, November 2024.
Abstract Alzheimer's disease (AD) is the most prevalent neurodegenerative disease and is a major health threat globally. Its prevalence is forecasted to exponentially increase during the next 30 years due to the global aging population. Currently, approved drugs are merely symptomatic, being ineffective in delaying or blocking the relentless disease ...
Paloma Mayo   +5 more
wiley   +1 more source

Toxicity of Cymbopogon flexuosus essential oil and citral for Spodoptera frugiperda

open access: yesCiência e Agrotecnologia
Fall armyworm (FAW) (Spodoptera frugiperda) is a polyphagous insect responsible for damage to several crops. Synthetic chemical insecticides and genetically modified plants are the most commonly used methods for FAW control.
Ellison Rosario de Oliveira   +5 more
doaj   +1 more source

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