Results 91 to 100 of about 24,505 (227)

From Regeneration Failure to Functional Restoration: Unlocking the Neuronal‐Intrinsic Regenerative Capacity as a Therapeutic Frontier for Optic Neuropathy and Glaucoma

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
Optic neuropathy and glaucoma cause permanent visual deficits via retinal ganglion cell (RGC) loss and axon degeneration, affecting millions worldwide. Current treatments slow disease progression but cannot restore lost vision due to regeneration failure in adult RGCs.
Emma Beard, Safa El‐Bushra, Zahra Kader, Yujiao Jennifer Sun, Ngan Pan Bennett Au   +4 more
wiley   +1 more source

Assessing Retinal Structure In Complete Congenital Stationary Night Blindness and Oguchi Disease [PDF]

, 2012
Purpose To examine retinal structure and changes in photoreceptor intensity after dark adaptation in patients with complete congenital stationary night blindness and Oguchi disease. Design Prospective, observational case series.
Carroll, Joseph, Cooper, Robert F., Diederichs, Melissa A., Dubis, Adam M., Dubra, Alfredo, Fishman, Gerald A., Genead, Mohamed, Godara, Pooja, Han, Dennis P., McAnany, J. Jason, Michaelides, Michel, Moore, Anthony T., Neitz, Maureen, Sergouniotis, Panagiotis I., Stone, Edwin M., Streb, Megan R., Webster, Andrew R.   +16 more
core   +2 more sources

The focal cone electroretinogram

Vision Research, 1995
The focal cone electroretinogram (ERG) in monkey retina has been examined with a 3 deg pulse of laser light (544 and 633 nm) centered on a 25 deg steady white rod saturating field. The stimuli were viewed simultaneously through a slit lamp and corneal contact lens. Cone ERGs were studied at different eccentricities from the fovea and compared with full-
Yamamoto, S., Gouras, P., Lopez, R.
openaire   +2 more sources

An experimental study to evaluate safety/toxicity of intravitreal natalizumab

Indian Journal of Ophthalmology, 2018
Purpose: The purpose of this prospective experimental study was to evaluate the safety/toxicity of α4β1 integrin blockade in rabbit retina using its monoclonal antibody (Natalizumab).
Rohan Chawla, Madhu Nath, Laxmi Moksha, Tapas C Nag, Thirumurthy Velpandian   +4 more
doaj   +1 more source

The Effects of L(+), D(-), and DL-2-amino-4-phosphonobutyrate (APB) on Electroretinogram and Ganglopn Cell Activity in the Cat Retina [PDF]

, 1995
L(+)-, D(-)-, or DL-2-amino-4-phosphonobutyric acid (APB; 2.5- 16 μmol) were injected into the vitreous body of anesthetized adult cats. The retina was stimulated by diffuse square wave light flashes (10- 60 ms). The flash-induced electroretinogram (ERU)
Grüsser, O.-J., Przybyszewski, A.W., Sucher, N.J.   +2 more
core   +1 more source

[Multifocal electroretinogram].

Klinika oczna, 2005
The paper presents current state of knowledge regarding multifocal electroretinography (mfERG). The theoretical basis of this technique, procedure, methods and examples of use in clinical diagnostics are presented.
Joanna A, Stepień, Herbert, Jaegle, Maciej W, Stepień, Wojciech, Omulecki   +3 more
openaire   +1 more source

Outer Retinal Dysfunction on Multifocal Electroretinography May Help Differentiating Multiple Sclerosis From Neuromyelitis Optica Spectrum Disorder

Frontiers in Neurology, 2019
Purpose: To evaluate the intermediate and outer retina of patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) using OCT and multifocal electroretinography (mf-ERG).Methods: Patients with MS (n = 30), NMOSD (n = 30 ...
Thiago G. Filgueiras, Maria K. Oyamada, Rony C. Preti, Samira L. Apóstolos-Pereira, Dagoberto Callegaro, Mário L. R. Monteiro   +5 more
doaj   +1 more source

Dysfunctional one-carbon metabolism identifies vitamins B6, B9, B12, and choline as neuroprotective in glaucoma

Cell Reports Medicine
Summary: Glaucoma, characterized by the loss of retinal ganglion cells (RGCs), is a leading cause of blindness for which there are no neuroprotective therapies.
James R. Tribble, Vickie H.Y. Wong, Kelsey V. Stuart, Glyn Chidlow, Alan Nicol, Anne Rombaut, Alessandro Rabiolo, Anh Hoang, Pei Ying Lee, Carola Rutigliani, Tim J. Enz, Alessio Canovai, Emma Lardner, Gustav Stålhammar, Christine T.O. Nguyen, David F. Garway-Heath, Robert J. Casson, Anthony P. Khawaja, Bang V. Bui, Pete A. Williams   +19 more
doaj   +1 more source

Visual Responses in Mice Lacking Critical Components of All Known Retinal Phototransduction Cascades [PDF]

, 2010
The mammalian visual system relies upon light detection by outer-retinal rod/cone photoreceptors and melanopsin-expressing retinal ganglion cells. Gnat1(-/-); Cnga3(-/-); Opn4(-/-) mice lack critical elements of each of these photoreceptive mechanisms ...
Allen, AE, Brown, TM, Cameron, MA, Lucas, RJ, Vugler, AA   +4 more
core  

Dynamic characterization of pathological and functional deterioration in a mouse model of optic neuritis related to neuromyelitis optica spectrum disorder

Neural Regeneration Research
Neuromyelitis optica spectrum disorder–related optic neuritis involves various cellular responses to inflammation and degeneration. In most patients, the primary mechanism underlying neuromyelitis optica spectrum disorder–related optic neuritis is the ...
Xiayin Yang, Shi-Qi Yao, Henry Ho-Lung Chan, Shaoying Tan   +3 more
doaj   +1 more source