Results 81 to 90 of about 24,505 (227)

Overproduction of 42 Amino Acids Long Amyloid Beta Leads to Activation of Secretory Autophagy and Development of Drusen‐Like Structures Originating From Retinal Pigment Epithelium

The FASEB Journal, Volume 40, Issue 5, 15 March 2026.
The role of 42 amino acids long amyloid beta (Aβ) in the retinal pigment epithelium (RPE) was investigated using 5xFAD mice model overproducing Aβ. The RPE cells of 5xFAD mice showed increased oxidative stress, accumulation of autophagy‐destined proteins, increased expression of secretory autophagy markers, and increase in epithelial‐to‐mesenchymal ...
Johanna Ruuth, Toni Tamminen, Elisa Toropainen, Heikki Tanila, Juha M. T. Hyttinen, Tarja Malm, Kai Kaarniranta, Ali Koskela   +7 more
wiley   +1 more source

Case series: The value of fundus autofluorescence in inherited macular disease

Optometry and Vision Science, Volume 103, Issue 3, March 2026.
ABSTRACT Purpose To evaluate the diagnostic utility of fundus autofluorescence (FAF) imaging in identifying and characterizing phenotypically classified inherited macular dystrophies. In this way, we aim to provide methods by which eye care practitioners can link FAF imaging and other clinical results or imaging modalities to aid their clinical ...
Marina Guro, Henrietta Wang, Jack Phu, Nimesh B. Patel, Kaitlyn A. Sapoznik, Hamza Shah, Michael Kalloniatis   +6 more
wiley   +1 more source

Intravitreal S100B Injection Leads to Progressive Glaucoma Like Damage in Retina and Optic Nerve

Frontiers in Cellular Neuroscience, 2018
The glial protein S100B, which belongs to a calcium binding protein family, is up-regulated in neurological diseases, like multiple sclerosis or glaucoma.
Sandra Kuehn, Wilhelm Meißner, Pia Grotegut, Carsten Theiss, H. Burkhard Dick, Stephanie C. Joachim   +5 more
doaj   +1 more source

Sex Differences in Metabolite–Immune Circuits of Neuroinflammation

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Sex is a fundamental yet underexplored determinant of human neuroinflammation. Across autoimmune, neurodegenerative, and post‐infectious neurological syndromes, males and females exhibit consistent differences in disease vulnerability, progression, and immune tone.
Priyanka Saminathan, Maija Corey, Alicia Gibbons, Mahati Rayadurgam, Neha Reddy, Pavithra Ramesh, Sonia Sharma   +6 more
wiley   +1 more source

Optic Chiasm and Bilateral Optic Nerve Oligodendroglioma in A 29‐Month‐Old German Shepherd

Veterinary Ophthalmology, Volume 29, Issue 2, March 2026.
ABSTRACT Objective To report the first documented case of high‐grade optic chiasm and nerve oligodendroglioma in a young dog and contribute to the comparative study of gliomas in humans and canines. Animal Studied A 29‐month‐old male intact German Shepherd.
Vienna M. Lunking, Rajdeep Multani, Devin Fussell, LaTisha N. Knight, Erin Keenihan, Danielle M. Meritet, Abigail R. Armwood, Annie Oh   +7 more
wiley   +1 more source

The White Coat Effect Influences Intraocular Pressure Measurements in Dogs: Comparing Tonometry Values Obtained in the Clinic Versus Home

Veterinary Ophthalmology, Volume 29, Issue 2, March 2026.
ABSTRACT Objective To determine the effect of clinic versus home environments on intraocular pressure (IOP) measurements in normotensive dogs. Animals Forty client‐owned normotensive dogs. Methods In a prospective crossover study, 40 normotensive dogs were included following a complete ophthalmic examination.
Ruth Pentlarge Barrow, Travis Strong, Kazuya Oikawa, Gillian J. McLellan, Ellison Bentley   +4 more
wiley   +1 more source

Oxidative Stress in Retinal Degeneration Promoted by Constant LED Light

Frontiers in Cellular Neuroscience, 2019
Light pollution by artificial light, might accelerate retinal diseases and circadian asynchrony. The excess of light exposure is a growing problem in societies, so studies on the consequences of long-term exposure to low levels of light are needed to ...
Maria M. Benedetto, Maria M. Benedetto, Maria A. Contin, Maria A. Contin   +3 more
doaj   +1 more source

The mouse pattern electroretinogram [PDF]

Documenta Ophthalmologica, 2007
Mouse models of optic nerve disease such as glaucoma, optic neuritis, ischemic optic neuropathy, and mitochondrial optic neuropathy are being developed at increasing rate to investigate specific pathophysiological mechanisms and the effect of neuroprotective treatments. The use of these models may be greatly enhanced by the availability of non-invasive
openaire   +2 more sources

FeDSNP‐Pa Nanoassemblies: A Triple‐Action Therapeutic Strategy Targeting Oxidative Stress, Inflammation, and Pyroptosis for Retinal Ganglion Cell Protection in Glaucoma

Advanced Functional Materials, Volume 36, Issue 11, 5 February 2026.
FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu, Xue Li, Tong Wu, Dan Ji, Yugang Bai, Xuezhi Zhou   +5 more
wiley   +1 more source

Evaluation of the protective role of ellagic acid in retinal degeneration: an experimental model

Journal of the Arab Society for Medical Research
Background/aim Ellagic acid (EA) is widely recognized as a natural compound with pharmacological potency as a polyphenolic molecule, possessing antioxidant, anti-inflammatory, antimutagenic, and antiproliferative characteristics.
Eman E. Mousa, Aziza A. Elsaied, Mohammad M. Murad, Amal E. Ibrahim   +3 more
doaj   +1 more source