Results 71 to 80 of about 21,943 (264)

Chronic electrical stimulation with a peripheral suprachoroidal retinal implant: a preclinical safety study of neuroprotective stimulation

Frontiers in Cell and Developmental Biology
PurposeExtraocular electrical stimulation is known to provide neuroprotection for retinal cells in retinal and optic nerve diseases. Currently, the treatment approach requires patients to set up extraocular electrodes and stimulate potentially weekly due
Carla J. Abbott, Carla J. Abbott, Penelope J. Allen, Penelope J. Allen, Penelope J. Allen, Chris E. Williams, Chris E. Williams, Richard A. Williams, Richard A. Williams, Stephanie B. Epp, Owen Burns, Ross Thomas, Mark Harrison, Patrick C. Thien, Patrick C. Thien, Alexia Saunders, Ceara McGowan, Caitlin Sloan, Chi D. Luu, Chi D. Luu, David A. X. Nayagam, David A. X. Nayagam   +21 more
doaj   +1 more source

A case study of Usher’s syndrome [PDF]

Perspectives In Medical Research, 2018
Usher’s syndrome is the most common condition that affects both hearing and vision. The major symptoms of Usher’s syndrome are hearing loss and an eye disorder called retinitis pigmentosa, or RP.
Kapil S1 , Arvind R2
doaj  

The Current Role and Prospects of Electrophysiological Research Methods in Ophthalmology. Literature Review

Oftalʹmologiâ, 2020
Electrophysiological research today remains an important method for the objective assessment of the functional state of the components of the visual analyzer.There are methods, for example, OCT, that can objectively assess the structural and anatomical ...
V. N. Kazajkin, V. O. Ponomarev, A. V. Lizunov, A. E. Zhdanov, A. Yu. Dolganov, V. I. Borisov   +5 more
doaj   +1 more source

Neurotoxicity risk assessment using of electroretinography [PDF]

, 2015
Предложен метод усовершенствования стандартных средств электроретинографии для применения при оценивании риска нейротоксикации. На базе концепции применения низко интенсивного импульсного воздействия светом на сетчатку глаза получена большая разрешающая ...
Ткачук, Роман Андрійович, Яворский, Б. И., Яворський, Богдан Іванович, Яненко, А. Ф.   +3 more
core  

Dark-adapted red flash ERGs in healthy adults [PDF]

, 2018
Purpose: The x-wave of the dark-adapted (DA) ERG to a red flash reflects DA cone function. This exploratory study of healthy adults aimed to investigate changes in the DA red ERG with flash strength and during dark adaptation to optimise visualisation ...
A Chia, A Vincent, DL McCulloch, E Auerbach, ED Adrian, ED Adrian, G Schubert Von, GL Horowitz, H Kawabata, J François, JC Armington, JV Lovasik, JYC Cheng, K Motokawa, K. Graham, KM Nishiguchi, LY Chen, PI Sergouniotis, R Hamilton, R. Hamilton, RA Armstrong, S Mizunoya, S-H Lim, VA McBain, X Liu, Y Miyake   +25 more
core   +1 more source

Targeting the NEK7/NLRP3 Inflammasome Axis: Synergistic Protection of Intravitreal MCC950 and Systemic Metformin Against Diabetic Retinopathy in Rats

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
Graphical Abstract ABSTRACT Objective Diabetic retinopathy (DR) is characterised by chronic neuroinflammation where the NLRP3 inflammasome plays a pivotal role. This study investigated the therapeutic potential and underlying mechanism of combining systemic metformin (MET) with intravitreal MCC950, a specific NLRP3 inhibitor, in a rodent model of DR ...
Kexuan Ren, Xiaofeng Li
wiley   +1 more source

Optimizing the use of angiogenesis inhibitor in neovascular age-related macular degeneration

Российский офтальмологический журнал, 2018
The purpose of the study was to estimate the effectiveness of using ranibizumab in combination with medotilin drug in the treatment of neovascular age-related macular degeneration (AMD). Material and methods. 50 patients (65 eyes) aged 41 to 88 (ave.
F. A. Bakhritdinova, A. F. Yusupov, Sh. A. Mukhanov   +2 more
doaj   +1 more source

Electroretinography in glaucoma diagnosis [PDF]

Current Opinion in Ophthalmology, 2016
Electrophysiological measures of vision function have for decades generated interest among glaucoma researchers and clinicians alike because of their potential to help elucidate pathophysiological processes and sequence of glaucomatous damage, as well as to offer a potential complementary metric of function that might be more sensitive than standard ...
Laura J, Wilsey, Brad, Fortune
openaire   +2 more sources

A Novel Intronic Variant Causes Aberrant Splicing of PCDH15 in a Family With Usher Syndrome Type 1F

Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.
Minigene splicing assays elucidated the pathogenicity of a novel intronic c.3717+5G>A mutation in the PCDH15 gene, which was identified in a family affected by Usher syndrome type 1F. The results demonstrated that the c.3717+5G>A mutation can lead to exon 27 skipping and retention of 51 bp at the 5′ end of intron 27, resulting in truncated or abnormal ...
Qifan Ma, Chenyang Xu, Xueqin Xu, Yanbao Xiang   +3 more
wiley   +1 more source

Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components

Small Methods, Volume 10, Issue 2, 22 January 2026.
The review presents a comprehensive overview of each component of lipid nanoparticles（LNPs）and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu, Nei Li, Yudian Xiao, Rohan Palanki, Hannah Yamagata, Michael J. Mitchell, Xuexiang Han   +6 more
wiley   +1 more source