Results 31 to 40 of about 16,832 (328)

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

open access: yesAdvanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji   +7 more
wiley   +1 more source

Study on the antiepyleptic activity of the new amide derivative of valproic acid and 1,3,4-thiadiazole

open access: yesЭпилепсия и пароксизмальные состояния, 2020
Aim – experimental evaluation of the antiepileptic activity of a new amide derivative of valproic acid and 1,3,4-thiadiazole.Materials and Methods: The antiepileptic activity of valprazolamide (N- (5-ethyl-1,3,4-thiadiazol-2-yl) -2-propylpentanamide) was
A. S. Malygin
doaj   +1 more source

How Can Network-Pharmacology Contribute to Antiepileptic Drug Development? [PDF]

open access: yes, 2014
Network-pharmacology is a field of pharmacology emerging from the observation that most clinical drugs have multiple targets, contrasting with the previously dominant magic bullet paradigm which proposed the search of exquisitely selective drugs. What is
Di Ianni, Mauricio Emiliano   +1 more
core   +1 more source

A study of the pharmacological actions of Dioclea grandiflora martius ex bentham [PDF]

open access: yes, 1995
Dioclea grandiflora Mart. ex Bent., known as Mucuna or Mucuna of stone, is a member of the Leguminosae family, popularly used for its possible effects on the Central Nervous System (CNS). Reports mention sedative, tonic, and also antiepileptic properties
Leite, Jose Roberto   +2 more
core   +1 more source

Enhancing Triplet Excitons Lifetime Through Controlled Intermolecular Interactions

open access: yesAdvanced Optical Materials, EarlyView.
Singlet fission (SF) is investigated in pentacene embedded in a surface‐anchored metal–organic framework, enabling a molecular arrangement inaccessible in pure organic crystals. This architecture changes the singlet fission dynamics significantly and enhances the triplet lifetime by almost four orders of magnitude.
Martin Richter   +9 more
wiley   +1 more source

Early career psychiatrists’ perceptions of and training experience in electroconvulsive therapy: A cross-sectional survey across Europe

open access: yesEuropean Psychiatry
Background Electroconvulsive therapy (ECT) is a safe and effective treatment for several major psychiatric conditions, including treatment-resistant depression, mania, and schizophrenia; nevertheless, its use remains controversial.
Cristiana Țăpoi   +18 more
doaj   +1 more source

Rapid discharges in a model Veterans Hospital [PDF]

open access: yes, 1955
Thesis (M.S.)--Boston ...
Gordon, Maurice H
core   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

open access: yesAdvanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang   +15 more
wiley   +1 more source

Anticonvulsant Activity of Viola tricolor against Seizures Induced by Pentylenetetrazol and Maximal Electroshock in Mice [PDF]

open access: yesIranian Journal of Medical Sciences, 2019
Background: Recently, there has been much more interest in the use of medicinal plants in search of novel therapies for human neurodegenerative diseases such as epilepsy. In the present study, we investigated the anticonvulsant effects of Viola tricolor (
Vafa Baradaran Rahimi   +4 more
doaj   +1 more source

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