Results 191 to 200 of about 210,261 (363)

Development of an Automated Workflow for Screening the Assembly and Host–Guest Behavior of Metal‐Organic Cages Towards Accelerated Discovery

open access: yesAngewandte Chemie, EarlyView.
An automated experimental workflow to accelerate the discovery of metal‐organic cages (MOCs), which is often hindered by slow, manual approaches, has been developed. Automation of the synthesis, characterization, and analysis, is supported by computational modelling to rationalize the experimental outcomes, and development of a host–guest assay ...
Annabel R. Basford   +8 more
wiley   +2 more sources

Adverse Cardiovascular Risk Profile and Increased Diurnal Salivary Cortisol in Girls With Turner Syndrome: An Exploratory Study

open access: yesAmerican Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Patients with Turner Syndrome (TS) and those exposed to high concentrations of glucocorticoids have a number of characteristics in common, including an increased risk of cardiovascular disease. Pediatric TS patients underwent studies of salivary cortisol (SC) and cortisone (SCn), body composition, continuous glucose monitoring, vascular ...
Lily Jones   +6 more
wiley   +1 more source

Ribozyme‐Catalyzed Site‐Specific Labeling of RNA Using O6‐alkylguanine SNAP‐Tag Substrates

open access: yesAngewandte Chemie, EarlyView.
SNAPR is a ribozyme that repurposes O6‐benzylguanine SNAP‐tag substrates for site‐specific labeling of RNA with bioorthogonal alkyne and azide functional groups, fluorophores or photocrosslinkers. The N1A‐alkylated RNA products were converted to N6A‐modified RNA by Dimroth rearrangement.
Manisha B. Walunj   +3 more
wiley   +2 more sources

A Novel Merocyanine Derivative for Probing Polarity at Cubosome Interfaces

open access: yesAsian Journal of Organic Chemistry, EarlyView.
This study develops a synthetic route to C10SP, a polarity‐sensitive sensor embedded in phytantriol‐based cubosomes. Strategic steps included tertiary amine‐mediated amidation to covalently attach a hydrophobic tail and controlled nitrogen methylation to form the iminium moiety within the indolenine scaffold.
Marcelo J. Eberhardt   +3 more
wiley   +1 more source

Ionic liquid electrospray beam target performance characterization. [PDF]

open access: yesJ Elect Propuls
Arestie SM   +2 more
europepmc   +1 more source

Alterations in gut microbiota and metabolites contribute to postoperative sleep disturbances

open access: yesAnimal Models and Experimental Medicine, EarlyView.
In this study, we classified postoperative patients into poor sleepers (PS) and good sleepers (GS) based on the bispectral index (BIS), and transplanted their fecal microbiota to pseudo‐germ‐free rats to analyze the sleep changes in rats and the potential mechanism.
Hui Zhong   +7 more
wiley   +1 more source

Association of environmental exposure to perchlorate, nitrate, and thiocyanate with overweight/obesity and central obesity among children and adolescents in the United States of America using data from the National Health and Nutrition Examination Survey (NHANES) 2005–2016

open access: yesNew Directions for Child and Adolescent Development, Volume 2022, Issue 185-186, Page 107-122, November 2022., 2022
Abstract The association of overweight/obesity, and central obesity with thiocyanate (SCN), perchlorate (CIO), and nitrate (NO) in childhood and adolescence is unclear. Therefore, this study aimed to explore this association in 4447 participants comprising children and adolescents (aged 6–19 years) using data from the United States National Health and ...
Qi Jiang, Qin Li
wiley   +1 more source

Structural Insight Into a Human H Ferritin@Gold‐Monocarbene Adduct: Aurophilicity Revealed in a Biological Context

open access: yesAngewandte Chemie, EarlyView.
Human H ferritin (HuHf) is a nanocarrier for anticancer metal drugs. By cryo‐EM, a 1.51 Å structure of its adduct with Au(NHC)Cl was solved, showing a novel tetranuclear gold(I) cluster bound to Cys90 and Cys102. Short inter‐metal distances indicate aurophilic interactions.
Lucrezia Cosottini   +9 more
wiley   +2 more sources

Identifying the optimal dose of cannabidiol by intrabuccal administration in Kramnik (C3HeB/FeJ) mice

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Cannabidiol (CBD) has numerous therapeutic properties, and is used to treat neurological conditions, such as neuroinflammation. However, the optimal dose of CBD to penetrate the brain requires further investigation. The primary aim of this study was to use a mouse model and the intrabuccal route for CBD administration to determine the optimal dose at ...
Oluwadara Pelumi Omotayo   +4 more
wiley   +1 more source

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