Results 311 to 320 of about 367,498 (388)

Real‐Time Eco–AI, Electrophoresis‐Correlative Data‐Dependent Acquisition with AI‐Based Data Processing Broadens Access to Single‐Cell Mass Spectrometry Proteomics

open access: yesAngewandte Chemie, EarlyView.
An affordable single‐cell proteomics workflow combines capillary electrophoresis, real‐time ion sorting, and AI‐aided spectral deconvolution to profile early Xenopus embryonic cells. Despite using a legacy Orbitrap, this strategy matches or exceeds the sensitivity of modern instruments, uncovering proteome dynamics at sub‐nanogram scale.
Bowen Shen, Fei Zhou, Peter Nemes
wiley   +1 more source

Decoding a Gut Commensal Signal: Structural and Immunological Profiling of Segatella Copri Lipopolysaccharide

open access: yesAngewandte Chemie, EarlyView.
The lipopolysaccharide (LPS) of Segatella copri is a structurally unique, immunomodulatory glycoconjugate. Combining mass spectrometry (MS), nuclear magnetic resonance (NMR), and cytometry by time‐of‐flight (CyTOF), we uncover a rough‐type LPS with reduced TLR4 agonism and selective monocyte effects, further highlighting the key role of LPS chemistry ...
Luca De Simone Carone   +17 more
wiley   +1 more source

Structural Dependence of Catenand Effect: Thermodynamic and Kinetic Modulation of Catenane Coordination Properties via Ring‐size and Exocyclic Substituent Variation

open access: yesAngewandte Chemie, EarlyView.
By modifying ring size and exocyclic substituents, effects of ligand interlocking on metal coordination features is explored. Through systematic analysis of CuI catenanes, relationship between structural parameters of the interlocked ligands and coordination properties like geometry, stability, and reactivity is established.
Yulin Deng   +8 more
wiley   +1 more source

NIR‐Activatable, Sequence‐Specific Metal‐Nucleic Acid Scaffolds for Responsive Uncaging

open access: yesAngewandte Chemie, EarlyView.
We demonstrate that long‐range nucleic acid‐mediated electron transfer can drive Pt(IV) photoreduction, establishing a new class of metal‐nucleic acid scaffolds capable of “responsive uncaging,” where hybridization with target DNA or miRNA directly triggers payload release under NIR irradiation.
Arpit Sharma   +6 more
wiley   +1 more source

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