Results 41 to 50 of about 312,664 (339)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Electrospray synthesis of PLGA TIPS microspheres [PDF]

, 2015
We successfully demonstrate the synthesis of polymer microspheres using a single electrospray source, and show their physical characterisation. Electrospray has proven to be a versatile method to manufacture particles, giving tight control over size with
Bowen, J., Day, R. M., Gomez, A., Kenyon, A. J., Malik, S. A., Ng, W. H., Tang, J.   +6 more
core  

Production of antibacterial compounds by a Steely hybrid polyketide synthase in Dictyostelium

FEBS Open Bio, EarlyView.
By selecting appropriate production species under optimised culture conditions, new chlorinated dibenzofuran compounds, which previously could not be analysed in sufficient quantities, were identified from cellular slime mould fruiting bodies. The strong antibacterial activity exhibited by these compounds suggests a link to the ecological function of ...
Tomoaki R. Yamashita, Toyonobu Usuki, Robert R. Kay, Tamao Saito   +3 more
wiley   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Mapping the Cytochrome C Folding Landscape [PDF]

, 2003
The solution to the riddle of how a protein folds is encoded in the conformational energy landscape for the constituent polypeptide. Employing fluorescence energy transfer kinetics, we have mapped the S.
Lyubovitsky, Julia Gennadievna
core   +1 more source

Fabrication of Polymeric Microparticles by Electrospray: The Impact of Experimental Parameters

Journal of Functional Biomaterials, 2020
Microparticles (MPs) with controlled morphologies and sizes have been investigated by several researchers due to their importance in pharmaceutical, ceramic, cosmetic, and food industries to just name a few. In particular, the electrospray (ES) technique
Alan Í. S. Morais, Ewerton G. Vieira, Samson Afewerki, Ricardo B. Sousa, Luzia M. C. Honorio, Anallyne N. C. O. Cambrussi, Jailson A. Santos, Roosevelt D. S. Bezerra, Josy A. O. Furtini, Edson C. Silva-Filho, Thomas J. Webster, Anderson O. Lobo   +11 more
doaj   +1 more source

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

Advanced Biology, EarlyView.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus   +10 more
wiley   +1 more source

The formation of mixed germanium–cobalt carbonyl clusters: an electrospray mass spectrometric study, and the structure of a high-nuclearity [Ge₂Co₁₀(CO)₂₄]²⁻ anion [PDF]

, 2001
The reaction of [µ₄-Ge{Co₂(CO)₇}₂] with [Co(CO)₄]⁻ has been monitored by electrospray mass spectrometry to detect the cluster anions generated. Conditions giving known mixed Ge–Co carbonyl clusters were established, and a new high nuclearity cluster ...
Evans, Cameron, Mackay, Kenneth M., Nicholson, Brian K.   +2 more
core   +2 more sources

Soy Protein Isolate Improved the Properties of Fish Oil-Loaded Chitosan–Sodium Tripolyphosphate Capsules

Foods
In this paper, the effect of soybean isolate protein (SPI) content on the physicochemical properties and oxidative stability of chitosan–sodium tripolyphosphate (CS-STPP)-loaded fish oil capsules was investigated.
Yunning Wang, Mubeen Asad, Deqian Wang, Xiaofan Gao, Guoliang Zheng, Jian Zhong, Jing Xie, Zhengquan Wang   +7 more
doaj   +1 more source

Nanoparticles Carrying Biological Molecules: Recent Advances and Applications

KONA Powder and Particle Journal, 2017
In the past few decades, enormous advances have been achieved in the field of particle technology and the trend has been shifted from macro to micro and recently to the nanoscale.
Suryani Saallah, I. Wuled Lenggoro
doaj   +1 more source