Results 101 to 110 of about 599,586 (355)

Crystalline‐Amorphous Heterostructure: A Novel Configuration for Silver Nanoclusters

Advanced Science, EarlyView.
This study presents a spontaneously formed amorphous‐crystalline heterostructure composite composed of atomically precise carboranylthiolate‐protected silver NCs, demonstrating not only a unique co‐assembly of distinct metal NCs at the macroscopic level but also promising potential applications of metal cluster‐based materials.
Jia‐Hong Huang, Yao Cui, Peng Luo, Zhao‐Yang Wang, Shuang‐Quan Zang   +4 more
wiley   +1 more source

RPL6 Interacts with HMGCS1 to Stabilize HIF‐1α by Promoting Cholesterol Production in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang, Shengtao Cheng, Huiying Gu, Shan Zhong, Dapeng Zhang, Xin He, Weixian Chen, Haijun Deng, Jihua Ren, Peng Chen, Ming Tan, Hui Zhang, Fan Li, Zhenzhen Zhang, Yuan Hu, Juan Chen   +15 more
wiley   +1 more source

Novel Cyano‐Artemisinin Dimer ZQJ29 Targets PARP1 to Induce Ferroptosis in Pancreatic Cancer Treatment

Advanced Science, EarlyView.
A novel artemisinin derivative dimer has been synthesized, and its significant potential as an anti‐cancer agent. The study indicated that ZQJ29 effectively inhibited the proliferation of pancreatic cancer cells in vitro and in vivo. Additionally, these investigations have unveiled ZQJ29 as a new potent PARP1 inhibitor, with the capability to induce ...
Jianping Chen, Lingyun Yue, Yanna Pan, Bingying Jiang, Junfeng Wan, Haixia Lin, Fujiang Guo, Huiyu Li, Yajuan Li, Qingjie Zhao   +9 more
wiley   +1 more source

Interaction between antitumor drugs and a double-stranded oligonucleotide studied by electrospray ionization mass spectrometry [PDF]

, 1999
Valérie Gabelica, Edwin De Pauw, Frédéric Rosu   +2 more
openalex   +1 more source

Fully Automated Deep Learning Enabled Miniature Mass Spectrometry System for Psychoactive Therapeutic Drug Monitoring

Advanced Science, EarlyView.
This study presents a fully automated miniature mass spectrometry system for high‐throughput therapeutic drug monitoring. Integrating magnetic solid‐phase extraction, self‐aspiration sampling miniature mass spectrometer, and U‐net deep learning quantitative algorithm, it achieves rapid (8 samples/30 min), precise (R2 > 0.99, RSD < 10%), and portable ...
Yuanhao Zhou, Jiawen Ai, Zi Ye, Kexin Chen, JingXiong Lin, Zhenhua Zhang, Mi Luo, Benjie Zhou, Shijian Xiang, Jianhua Zhou, Xinming Huo   +10 more
wiley   +1 more source

Structural characterization of molecular phospholipid species in cytoplasmic membranes of the cell wall-less Streptomyces hygroscopicus L form by use of electrospray ionization coupled with collision-induced dissociation mass spectrometry [PDF]

, 1997
Christian Hoischen, W. Ihn, K Gura, J. Gumpert   +3 more
openalex   +1 more source

Fast pH‐Driven Solubilization Method of Realgar (As4S4) to Reduce the Toxicity of Arsenic [As(III)] for Medicinal Purposes

Advanced Science, EarlyView.
Arsenic trioxide transformed acute promyelocytic leukemia therapy and shows promise against HIV. A new method to solubilize the mineral realgar produces different arsenic species depleting the main arsenic target, nuclear PML protein, and retaining effects on leukemic and HIV reservoir cells, while minimizing off‐target damage.
Bojana Lucic, Douglas Santana Franciscato, Helton Pereira Nogueira, Lara Gallucci, Alceu Totti Silveira Junior, Asmaa Mohamed Ismail, Millie Robinson, Teresa Dallinger, Claudia Gutfleisch, Jochen Kurz, Maytê Toledo, Jessica Dias da Silva Ferraz, Mohammad Tarek, Danilo Dias, Ricardo Sobhie Diaz, Mahmoud ElHefnawi, Mattia Forcato, Hugo P Monteiro, Marina Lusic, Iart Luca Shytaj, Andrea Savarino   +20 more
wiley   +1 more source

Quantitative measurement of different ceramide species from crude cellular extracts by electrospray ionization tandem mass spectrometry (ESI-MS/MS) [PDF]

, 1999
Gerhard Liebisch, Wolfgang Drobnik, Markus Reil, Barbara Trümbach, Ralf Arnecke, B. Olgemöller, A. Roscher, Gerd Schmitz   +7 more
openalex   +1 more source

SF3A3 Drives Tumorigenesis in Endometrial Cancer by Enhancing c‐FOS Expression and Represents a Potential Therapeutic Target

Advanced Science, EarlyView.
The role of splicing factor 3A subunit 3 (SF3A3) in driving endometrial cancer (EC) progression and potential therapeutic interventions. SF3A3, a core component of the U2 small nuclear ribonucleoprotein (U2 snRNP), is upregulated in endometrial cancer (EC) and promotes tumor growth and cisplatin resistance. RNA‐binding protein immunoprecipitation (RIP)
Wei Yu, Yi Gu, Hengrui Zhang, Wunan Huang, Lei Sun, Liangjian Ma, Xiaolei Liang, Lexin Liu, Guiping Chen, Weihua Wang, Zhongkai Cao, Xue Li, Xiangjun Chen, Lidan Hu   +13 more
wiley   +1 more source

Molecular weight determination of plasmid DNA using electrospray ionization mass spectrometry [PDF]

, 1996
Xueheng Cheng
openalex   +1 more source