Results 111 to 120 of about 149,784 (296)

Vascularized Liver‐on‐a‐Microsphere Reveals Alanine‐Glucose Metabolism‐Driven Regulation of Liver Function and Injury

Advanced Science, EarlyView.
A vascularized liver‐on‐a‐microsphere system is developed to recreate lobule‐like cellular organization and endothelial barrier function within compartmentalized hydrogel particles. The platform enhances hepatic performance and reveals alanine‐glucose cycle activation linked to improved detoxification capacity, offering a high‐throughput microscale ...
Jingyang Li, Zengnan Wu, Yingrui Zhang, Shulang Chen, Yongning Lin, Shiyu Chen, Tong Xu, Xianli Meng, Yi Zhang, Jin‐Ming Lin   +9 more
wiley   +1 more source

The factors and protocols that influence, accuracy, precision and uncertainty of accurate mass measurements by FT-ICR ms to validate the assignment of elemental composition [PDF]

, 2009
The need for very accurate mass measurements of compounds is becoming more demanding with the expansion of the number of compounds in need of correct identification and with the limits of elemental analysis; a fast, robust analytical solution is sought ...
Wronska, Louisa Victoria May
core  

Characterization of Synthetic and Natural Product Pharmaceuticals by Functional Group Analysis using Electrospray Ionization-Ion Trap Mass Spectrometry: A Mini-Review [PDF]

, 2015
This mini-review is concerned with the characterization of synthetic and natural product pharmaceuticals by functional group analysis using electrospray ionization-ion trap mass spectrometry.
Rodriguez Robledo, Virgina, McClean, Stephen, Smyth, Thomas J, Smyth, W. F., McClean, S., Brooks, P., Massaro, C. F., Brooks, P R, Robledo, V. R., Massaro, C F, Franklin Smyth, W, Smyth, T. J.   +11 more
core   +1 more source

Light-Dependent Changes in the Spatial Localization of Metabolites in Solenostemon scutellarioides (Coleus Henna) Visualized by Matrix-Free Atmospheric Pressure Electrospray Laser Desorption Ionization Mass Spectrometry Imaging

Frontiers in Plant Science, 2018
The visualization of foliage color in plants provides immediate insight into some of the compounds that exist in the leaf. However, many non-colored compounds are also present; their cellular distributions are not readily identifiable optically.
Patrick A. McVey, Patrick A. McVey, Liza E. Alexander, Liza E. Alexander, Liza E. Alexander, Xinyu Fu, Xinyu Fu, Xinyu Fu, Bo Xie, Katherine-Jo Galayda, Katherine-Jo Galayda, Basil J. Nikolau, Basil J. Nikolau, Basil J. Nikolau, Robert S. Houk, Robert S. Houk   +15 more
doaj   +1 more source

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source

ISOLATION AND STRUCTURE DETERMINATION OF BISDEMTHYLAAPTAMINE FROM BUNAKEN MARINE PARK SPONGE Aaptos, sp.

Indonesian Journal of Chemistry, 2010
Bisdemethylaaptamine, an alkaloid naphtyridine with molecular weight 200 and formulae molecule C11H8N2O2 has been isolated from Bunaken Marine Park sponge Aaptos sp. Isolation was done by using several stages of column chromatography and high performance
Wilson AR Rombang, Rymond J Rumampuk, Ponis Tarigan, Anthony J Herlt, Lewis N Mander   +4 more
doaj   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

Electrospray ionization tandem mass spectrometry of 4-aryl-3,4-dihydrocoumarins [PDF]

We have investigated the gas-phase fragmentation reactions of eleven synthetic 4-aryl-3,4-dihydrocoumarins by electrospray ionization tandem mass spectrometry (ESI-MS/MS) on a quadrupole-time-of flight (Q-TOF) hybrid mass spectrometer.
William, Santos, Herbert, Dias, Eduardo, Crevelin, J. Scott, McIndoe, Luiz Carlos, Silva-Filho, Antônio, Crotti, Ricardo, Vessecchi   +6 more
core   +1 more source

Ionization Process and Electrospray.

Journal of the Mass Spectrometry Society of Japan, 1996
Scientist observed natural phenomena and found the existence of ions more than 100 years ago. When the historical background of electrospray was surveyed from the view point of the ionization technique, the origin started by the awareness of the charged drops in nature. Our earth is positively charged and abounds in the positive ion.
openaire   +2 more sources

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

Advanced Science, EarlyView.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker, Elodie L. Rey, Clara Stanschewski, Regina Wendenburg, Annabella Klemmer, Markéta Macho, Venkatesh P. Thirumalaikumar, Noha O. Saber, Aleksandra Skirycz, Alisdair R. Fernie, Mark Tester, Saleh Alseekh   +11 more
wiley   +1 more source