Results 1 to 10 of about 345,762 (348)

Mass spectrometry imaging with high resolution in mass and space [PDF]

Histochemistry and Cell Biology, 2013
Mass spectrometry (MS) imaging links molecular information and the spatial distribution of analytes within a sample. In contrast to most histochemical techniques, mass spectrometry imaging can differentiate molecular modifications and does not require ...
Andreas Römpp, Bernhard Spengler
exaly   +2 more sources

Comparison of Local Metabolic Changes in Diabetic Rodent Kidneys Using Mass Spectrometry Imaging

Metabolites, 2023
Understanding the renal region-specific metabolic alteration in different animal models of diabetic nephropathy (DN) is critical for uncovering the underlying mechanisms and for developing effective treatments.
Xin Zhang, Yanhua Liu, Shu Yang, Xin Gao, Shuo Wang, Zhaoying Wang, Chen Zhang, Zhi Zhou, Yanhua Chen, Zhonghua Wang, Zeper Abliz   +10 more
doaj   +1 more source

Basal ganglia neuropeptides show abnormal processing associated with L-DOPA-induced dyskinesia

npj Parkinson's Disease, 2022
L-DOPA administration is the primary treatment for Parkinson’s disease (PD) but long-term administration is usually accompanied by hyperkinetic side-effects called L-DOPA-induced dyskinesia (LID). Signaling neuropeptides of the basal ganglia are affected
Heather Hulme, Elva Fridjonsdottir, Theodosia Vallianatou, Reza Shariatgorji, Anna Nilsson, Qin Li, Erwan Bezard, Per E. Andrén   +7 more
doaj   +1 more source

Optimized protocol for MALDI MSI of N-glycans using an on-tissue digestion in fresh frozen tissue sections

Scientific Reports, 2023
Glycans play an important role in biology with multiple cellular functions ranging from cell signaling, mobility and growth to protein folding and localization.
Andrej Grgic, Kasper K. Krestensen, Ron M. A. Heeren   +2 more
doaj   +1 more source

Proteomic Analysis of the Cold Stress Response of Ammopiptanthus mongolicus Reveals the Role of AmCHIA in Its Cold Tolerance

Horticulturae, 2023
Ammopiptanthus mongolicus, a traditional ethnic medicinal herb, is a rare broad-leaved evergreen shrub in the arid region of central Asia that can survive under extremely low temperatures during winter.
Xuting Li, Qi Liu, Rongqi Wu, Jie Bing, Lamei Zheng, Batu Sumbur, Yijun Zhou, Fei Gao   +7 more
doaj   +1 more source

Оптимізм і песимізм в етичних концепціях М.Я. Грота, А. Швейцера, Н. Аббаньяно [PDF]

, 2008
RATIONALE: Microscope mode imaging for secondary ion mass spectrometry is a technique with the promise of simultaneous high spatial resolution and high-speed imaging of biomolecules from complex surfaces.
Heeren, R.M.A., Jungmann, JH, Kiss, A., Smith, D.F.   +3 more
core   +3 more sources

The diagnostic accuracy of intraoperative differentiation and delineation techniques in brain tumours

Discover Oncology, 2022
Brain tumour identification and delineation in a timeframe of seconds would significantly guide and support surgical decisions. Here, treatment is often complicated by the infiltration of gliomas in the surrounding brain parenchyma.
Laura Van Hese, Steven De Vleeschouwer, Tom Theys, Steffen Rex, Ron M. A. Heeren, Eva Cuypers   +5 more
doaj   +1 more source

Comparison of Osteosarcoma Aggregated Tumour Models with Human Tissue by Multimodal Mass Spectrometry Imaging

Metabolites, 2021
Osteosarcoma (OS) is the most common primary bone malignancy and largely effects adolescents and young adults, with 60% of patients under the age of 25. There are multiple cell models of OS described in vitro that express the specific genetic alterations
Lucy E. Flint, Gregory Hamm, Joseph D. Ready, Stephanie Ling, Catherine J. Duckett, Neil A. Cross, Laura M. Cole, David P. Smith, Richard J. A. Goodwin, Malcolm R. Clench   +9 more
doaj   +1 more source

Simultaneous mass spectrometry imaging of multiple neuropeptides in the brain and alterations induced by experimental parkinsonism and L-DOPA therapy

Neurobiology of Disease, 2020
Neuropeptides are important signalling molecules in the brain and alterations in their expression levels have been linked to neurological disorders such as Parkinson's disease. It is challenging to map neuropeptide changes across and within brain regions
Heather Hulme, Elva Fridjonsdottir, Halla Gunnarsdottir, Theodosia Vallianatou, Xiaoqun Zhang, Henrik Wadensten, Reza Shariatgorji, Anna Nilsson, Erwan Bezard, Per Svenningsson, Per E. Andrén   +10 more
doaj   +1 more source

Non-invasive screening of breast cancer from fingertip smears—a proof of concept study

Scientific Reports, 2023
Breast cancer is a global health issue affecting 2.3 million women per year, causing death in over 600,000. Mammography (and biopsy) is the gold standard for screening and diagnosis.
C. Russo, L. Wyld, M. Da Costa Aubreu, C. S. Bury, C. Heaton, L. M. Cole, S. Francese   +6 more
doaj   +1 more source