Results 41 to 50 of about 345,762 (348)

Mass spectrometry imaging of 3D tissue models [PDF]

, 2018
A 3D cell culture is an artificially created environment in which cells are permitted to grow/interact with their surroundings in all three dimensions.
Clench, Malcolm, Flint, Lucy, Lewis, Emily, Russo, Cristina   +3 more
core   +1 more source

Lipid changes within the epidermis of living skin equivalents observed across a time-course by MALDI-MS imaging and profiling [PDF]

, 2015
© 2015 Mitchell et al. Abstract Background: Mass spectrometry imaging (MSI) is a powerful tool for the study of intact tissue sections. Here, its application to the study of the distribution of lipids in sections of reconstructed living skin equivalents ...
Clench, Malcolm, Donaldson, M., Francese, S., Long, H., Mitchell, C.A.   +4 more
core   +2 more sources

Introduction of 4-chloro-alpha-cyanocinnamic acid liquid matrices for high sensitivity UV-MALDI MS [PDF]

, 2010
Matrix-assisted laser desorption/ionization (MALDI) is a key ionization technique in mass spectrometry (MS) for the analysis of labile macromolecules.
Cramer, Rainer, McKendrick, John E., Towers, Mark W.   +2 more
core   +1 more source

Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents

Nature Communications, 2023
Prosaposin (PSAP) modulates glycosphingolipid metabolism and variants have been linked to Parkinson’s disease (PD). Here, we find altered PSAP levels in the plasma, CSF and post-mortem brain of PD patients.
Yachao He, Ibrahim Kaya, Reza Shariatgorji, Johan Lundkvist, Lars U. Wahlberg, Anna Nilsson, Dejan Mamula, Jan Kehr, Justyna Zareba-Paslawska, Henrik Biverstål, Karima Chergui, Xiaoqun Zhang, Per E. Andren, Per Svenningsson   +13 more
doaj   +1 more source

Integrated mass spectrometry imaging reveals spatial-metabolic alteration in diabetic cardiomyopathy and the intervention effects of ferulic acid

Journal of Pharmaceutical Analysis, 2023
Diabetic cardiomyopathy (DCM) is a metabolic disease and a leading cause of heart failure among people with diabetes. Mass spectrometry imaging (MSI) is a versatile technique capable of combining the molecular specificity of mass spectrometry (MS) with ...
Yanhua Liu, Xin Zhang, Shu Yang, Zhi Zhou, Lu Tian, Wanfang Li, Jinfeng Wei, Zeper Abliz, Zhonghua Wang   +8 more
doaj   +1 more source

Hepatocellular carcinoma: Review of disease and tumor biomarkers. [PDF]

, 2016
© The Author(s) 2016.Hepatocellular carcinoma (HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative
Cox, IJ, Crossey, MM, Fye, HK, Gomez-Romero, M, Holmes, E, Kim, JU, Njie, R, Shariff, MI, Taylor-Robinson, SD   +8 more
core   +1 more source

Statistical Modelling Investigation of MALDI-MSI-Based Approaches for Document Examination

Molecules, 2023
Questioned document examination aims to assess if a document of interest has been forged. Spectroscopy-based methods are the gold standard for this type of evaluation.
Johan Kjeldbjerg Lassen, Robert Bradshaw, Palle Villesen, Simona Francese   +3 more
doaj   +1 more source

Systematic review and quality analysis of emerging diagnostic measures for calcium pyrophosphate crystal deposition disease. [PDF]

, 2016
ObjectivesCalcium pyrophosphate crystal deposition disease (CPPD) is common, yet prevalence and overall clinical impact remain unclear. Sensitivity and specificity of CPPD reference standards (conventional crystal analysis (CCA) and radiography (CR ...
Chen, K, Terkeltaub, R, Wu, Y
core   +1 more source

Deficits in Motor Performance, Neurotransmitters and Synaptic Plasticity in Elderly and Experimental Parkinsonian Mice Lacking GPR37

Frontiers in Aging Neuroscience, 2020
Parkinson’s disease (PD) etiology is attributed to aging and the progressive neurodegeneration of dopamine (DA) neurons of substantia nigra pars compacta (SNc).
Xiaoqun Zhang, Ioannis Mantas, Elva Fridjonsdottir, Per E. Andrén, Per E. Andrén, Karima Chergui, Per Svenningsson   +6 more
doaj   +1 more source

Development of Imaging Mass Spectrometry

Biological & Pharmaceutical Bulletin, 2012
We have developed a mass microscope in which a microscope is combined with high-resolution matrix assisted laser desorption/ionization-imaging mass spectrometry (MALDI-IMS). This technique is a powerful tool for investigating the spatial distribution of biomolecules without the need for any time-consuming extraction, purification, and labeling ...
Yusuke, Saito, Michihiko, Waki, Saira, Hameed, Takahiro, Hayasaka, Mitsutoshi, Setou   +4 more
openaire   +3 more sources