rMSIfragment: improving MALDI-MSI lipidomics through automated in-source fragment annotation [PDF]
Journal of Cheminformatics, 2023 Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging (MALDI-MSI) spatially resolves the chemical composition of tissues. Lipids are of particular interest, as they influence important biological processes in health and disease.
Gerard Baquer +7 more
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Identifying space-resolved proteins of the murine thymus, by combining MALDI-MSI and proteomics [PDF]
Life Science AllianceWe developed a combined MALDI-MSI and LC-MS/MS workflow integrating a scoring algorithm (pepBridge) to achieve confident spatial protein identification in the thymus, revealing chemotherapy-induced spatiotemporal remodeling and identifying candidate ...
Jennifer T Aguilan +5 more
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MALDI-MSI-Guided Laser Capture Microdissection Coupled with MS for Integrated Spatial Multi-Omics in Mouse Brain [PDF]
LifeSpatial multi-omics analyzes biomolecules such as the proteome, metabolome, and lipidome within their native spatial context in tissues or cells.
Byoung-Kyu Cho +8 more
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Optimized combination of MALDI MSI and immunofluorescence for neuroimaging of lipids within cellular microenvironments [PDF]
Frontiers in ChemistryProper neurological function relies on the cellular and molecular microenvironment of the brain, with perturbations of this environment leading to neurological disorders. However, studying the microenvironments of neurological tissue has proven difficult
Catelynn C. Shafer, Elizabeth K. Neumann
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One section, two worlds: single-cell integration of MALDI-MSI and spatial transcriptomics on the same single tissue section [PDF]
Scientific ReportsUnderstanding tissue complexity requires spatially resolved multi-omics data at single-cell resolution. Here, we present a workflow integrating high-resolution matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) with Xenium ...
Tim F. E. Hendriks +5 more
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Research Progress of Derivatization Method in MALDI Mass Spectrometry Imaging [PDF]
Zhipu Xuebao, 2021 Matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) has been developed rapidly in recent years and has been widely used in many fields.
WANG Shan-shan +2 more
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Pharmaceuticals, 2022 Mass spectrometry imaging (MSI) is well-known for the non-labeling visualization of analytes, including drugs and their metabolites in biological samples.
Ariful Islam +7 more
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Microbiology Spectrum, 2021 Matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) is commonly used by clinical microbiology laboratories to identify pathogens, despite some limitations of the technique.
Alexandre Godmer +8 more
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Metabolites, 2022 Salivary gland tumors are relatively uncommon neoplasms that represent less than 5% of head and neck tumors, and about 90% are in the parotid gland. The wide variety of histologies and tumor characteristics makes diagnosis and treatment challenging.
Eduardo Sommella +11 more
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Unique distribution of ellagitannins in ripe strawberry fruit revealed by mass spectrometry imaging
Current Research in Food Science, 2021 Ellagitannins (ETs) are hydrolysable tannins composed of a polyol core, primarily glucose, which is esterified with hexahydroxydiphenic acid (HHDP), and in some cases, gallic acid.
Hirofumi Enomoto
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