MALDI-MSI Towards Multimodal Imaging: Challenges and Perspectives [PDF]
Frontiers in Chemistry, 2022 Multimodal imaging is a powerful strategy for combining information from multiple images. It involves several fields in the acquisition, processing and interpretation of images.
Michael Tuck +3 more
doaj +4 more sources
rMSIfragment: improving MALDI-MSI lipidomics through automated in-source fragment annotation [PDF]
Journal of Cheminformatics, 2023 Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging (MALDI-MSI) spatially resolves the chemical composition of tissues. Lipids are of particular interest, as they influence important biological processes in health and disease.
Gerard Baquer +7 more
doaj +2 more sources
Optimized protocol for MALDI MSI of N-glycans using an on-tissue digestion in fresh frozen tissue sections [PDF]
Scientific Reports, 2023 Glycans play an important role in biology with multiple cellular functions ranging from cell signaling, mobility and growth to protein folding and localization.
Andrej Grgic +2 more
doaj +2 more sources
Identifying space-resolved proteins of the murine thymus, by combining MALDI-MSI and proteomics [PDF]
Life Science AllianceWe developed a combined MALDI-MSI and LC-MS/MS workflow integrating a scoring algorithm (pepBridge) to achieve confident spatial protein identification in the thymus, revealing chemotherapy-induced spatiotemporal remodeling and identifying candidate ...
Jennifer T Aguilan +5 more
doaj +2 more sources
Research Progress on the Application of MALDI-MSI in Hair Analysis
Fayixue ZazhiMass spectrometry imaging （MSI） is an emerging high-tech “photography” method combining mass spectrometry and image visualization technologies, which can simultaneously monitor the spatial distribution of multiple molecules in biological samples.
JI Jiao-jiao +5 more
doaj +3 more sources
The use of MALDI‐MSI in the investigation of psychiatric and neurodegenerative disorders: A review [PDF]
Proteomics, 2016 Matrix‐assisted laser desorption/ionization mass spectrometry imaging (MALDI‐MSI) is a mass spectrometry technique used for the analysis of macromolecules on an intact tissue of interest, thereby allowing the assessment of molecular signatures in health and disease in the anatomical context.
Klaus Oliver Schubert, Florian Weiland
exaly +4 more sources
High-throughput MALDI-MSI metabolite analysis of plant tissue microarrays. [PDF]
Plant Biotechnol J, 2023 SummaryA novel metabolomics analysis technique, termed matrix‐assisted laser desorption/ionization mass spectrometry imaging‐based plant tissue microarray (MALDI‐MSI‐PTMA), was successfully developed for high‐throughput metabolite detection and imaging from plant tissues.
Huang H +15 more
europepmc +3 more sources
Optimized combination of MALDI MSI and immunofluorescence for neuroimaging of lipids within cellular microenvironments [PDF]
Frontiers in ChemistryProper neurological function relies on the cellular and molecular microenvironment of the brain, with perturbations of this environment leading to neurological disorders. However, studying the microenvironments of neurological tissue has proven difficult
Catelynn C. Shafer, Elizabeth K. Neumann
doaj +2 more sources
MALDI MSI of MeLiM melanoma: Searching for differences in protein profiles. [PDF]
PLoS ONE, 2017 Treatment of advanced cutaneous melanoma remains challenging, and new data on melanoma biology are required. The most widely accepted criteria for the prognostic evaluation of melanoma are histopathological and clinical parameters, and the identification
Roman Guran +7 more
doaj +5 more sources
One section, two worlds: single-cell integration of MALDI-MSI and spatial transcriptomics on the same single tissue section [PDF]
Scientific ReportsUnderstanding tissue complexity requires spatially resolved multi-omics data at single-cell resolution. Here, we present a workflow integrating high-resolution matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) with Xenium ...
Tim F. E. Hendriks +5 more
doaj +2 more sources