Results 41 to 50 of about 95,119 (201)

Recent developments of MALDI MSI application in plant tissues analysis

Acta Biochimica Polonica, 2020
Mass spectrometry imaging (MSI) combined with matrix-assisted laser desorption/ionization (MALDI) is an efficient technology applied in plant metabolomics research. This technique allows for visualization of spatial distribution of metabolites such as: lipids, proteins, peptides and DNA sequences, by determining the x, y coordinates of the compounds ...
Katarzyna Susniak, Mikołaj Krysa, Barbara Gieroba, Iwona Komaniecka, Anna Sroka-Bartnicka   +4 more
openaire   +3 more sources

Chemical Mapping of the Degradation of Geranium Lake in Paint Cross Sections by MALDI-MSI

, 2023
Matrix assisted laser desorption ionization-mass spectrometry imaging (MALDI-MSI) has become a powerful method to extract spatially resolved chemical information in complex materials.
Ermanno Avranovich Clerici (17444416), Alba Alvarez-Martin (7162883), Jusal Quanico (1917355), Teresa Scovacricchi (17444413), Koen Janssens (219438), Geert Baggerman (702592)   +5 more
core   +1 more source

Bringing SEM and MSI Closer Than Ever Before: Visualizing Aspergillus and Pseudomonas Infection in the Rat Lungs

Journal of Fungi, 2020
A procedure for processing frozen rat lung tissue sections for scanning electron microscopy (SEM) from deeply frozen samples initially collected and stored for matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) was ...
Tereza Juříková, Dominika Luptáková, Olga Kofroňová, Anton Škríba, Jiří Novák, Helena Marešová, Andrea Palyzová, Miloš Petřík, Vladimír Havlíček, Oldřich Benada   +9 more
doaj   +1 more source

Evaluation of Quantitative Platforms for Single Target Mass Spectrometry Imaging

Pharmaceuticals, 2022
(1) Imaging of pharmaceutical compounds in tissue is an increasingly important subsection of Mass Spectrometry Imaging (MSI). Identifying proper target engagement requires MS platforms with high sensitivity and spatial resolution.
Andrew P. Bowman, James Sawicki, Nari N. Talaty, Wayne R. Buck, Junhai Yang, David S. Wagner   +5 more
doaj   +1 more source

Advances in MALDI Mass Spectrometry Imaging Single Cell and Tissues

Frontiers in Chemistry, 2022
Compared with conventional optical microscopy techniques, mass spectrometry imaging (MSI) or imaging mass spectrometry (IMS) is a powerful, label-free analytical technique, which can sensitively and simultaneously detect, quantify, and map hundreds of ...
Xiaoping Zhu, Xiaoping Zhu, Tianyi Xu, Tianyi Xu, Chen Peng, Shihua Wu, Shihua Wu   +6 more
doaj   +1 more source

6-Aza-2-Thiothymine as an Alternative Matrix for Spatial Proteomics with MALDI-MSI. [PDF]

Int J Mol Sci
Matrix Assisted Laser Desorption/Ionisation-Mass Spectrometry Imaging (MALDI-MSI) is a well-established spatial omic technique which enables the untargeted mapping of various classes of biomolecules, including tryptic peptides, directly on tissue.
Denti V, Monza N, Bindi G, Porto NS, L'Imperio V, Pagni F, Piga I, Smith A.   +7 more
europepmc   +2 more sources

MALDI-IHC-Guided In-Depth Spatial Proteomics: Targeted and Untargeted MSI Combined

, 2023
Recently, a novel technology was published, utilizing the strengths of matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) and immunohistochemistry (IHC), achieving highly multiplexed, targeted imaging of biomolecules in ...
Grgic, A., Heeren, Ron M. A., Britt S. R. Claes (11085021), Michiel Vandenbosch (14425444), Yagnik, G., Vandenbosch, M., Rothschild, K.J., Kasper K. Krestensen, Krestensen, Kasper K., Andrej Grgic, Kenneth J. Rothschild, Michiel Vandenbosch, Krestensen, K.K., Kuik, Christel, Mark J. Lim, Kasper K. Krestensen (14425435), Yagnik, Gargey, Claes, Britt S. R., Heeren, R.M.A., Lim, Mark J., Lim, M.J., Gargey Yagnik, Christel Kuik (14425441), Ron M. A. Heeren (7181636), Ron M. A. Heeren, Gargey Yagnik (1910416), Christel Kuik, Kenneth J. Rothschild (1324134), Andrej Grgic (14425438), Britt S. R. Claes, Vandenbosch, Michiel, Mark J. Lim (4814295), Claes, B.S.R., Grgic, Andrej, Kuik, C., Rothschild, Kenneth J.   +35 more
core   +1 more source

On-Tissue Derivatization of Lipopolysaccharide for Detection of Lipid A Using MALDI-MSI

Analytical Chemistry, 2020
We developed a method to directly detect and map the Gram-negative bacterial virulence factor lipid A derived from lipopolysaccharide (LPS) by coupling acid hydrolysis with matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI). As the structure of lipid A (endotoxin) determines the innate immune outcome during infection, the
Hyojik Yang, Courtney E. Chandler, Shelley N. Jackson, Amina S. Woods, David R. Goodlett, Robert K. Ernst, Alison J. Scott   +6 more
openaire   +5 more sources

Enhanced Sensitivity Using MALDI Imaging Coupled with Laser Postionization (MALDI-2) for Pharmaceutical Research

, 2019
Visualizing the distributions of drugs and their metabolites is one of the key emerging application areas of matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) within pharmaceutical research.
Vreeken, Rob J., Flinders, Bryn, Heeren, Ron M. A., Barre, Florian P. Y., Cillero-Pastor, Berta, Heeren, Ron M.A., Garcia, Joao P., Trevitt, Adam J., Barré, Florian P.Y., Ellis, Shane R., Vreeken, Rob J.; id_orcid, Paine, Martin R.L., Kelly, Patrick D., Stauber, Jonathan, Ait-Belkacem, Rima, Paine, Martin R. L., Creemers, Laura B., Regenerative Medicine and Stem Cells, Orthopaedie Onderzoek, UMC Utrecht   +19 more
core   +4 more sources

MALDI-MSI-LC-MS/MS Workflow for Single-Section Single Step Combined Proteomics and Quantitative Lipidomics. [PDF]

Anal Chem
We introduce a novel approach for comprehensive molecular profiling in biological samples. Our single-section methodology combines quantitative mass spectrometry imaging (Q-MSI) and a single step extraction protocol enabling lipidomic and proteomic ...
Hendriks TFE, Krestensen KK, Mohren R, Vandenbosch M, De Vleeschouwer S, Heeren RMA, Cuypers E.   +6 more
europepmc   +2 more sources