Results 41 to 50 of about 187,471 (221)

Imaging mass spectrometry identifies prognostic ganglioside species in rodent intracranial transplants of glioma and medulloblastoma. [PDF]

PLoS ONE, 2017
Matrix-assisted laser desorption ionization (MALDI) imaging mass spectrometry (MALDI-MSI) allows us to investigate the distribution of lipid molecules within tissues.
Leonardo Ermini, Elena Morganti, Alexander Post, Behzad Yeganeh, Isabella Caniggia, Michael Leadley, Claudia C Faria, James T Rutka, Martin Post   +8 more
doaj   +1 more source

Matrix-Free High-Resolution Atmospheric-Pressure SALDI Mass Spectrometry Imaging of Biological Samples Using Nanostructured DIUTHAME Membranes

Metabolites, 2021
Applications of mass spectrometry imaging (MSI), especially matrix-assisted laser desorption/ionization (MALDI) in the life sciences are becoming increasingly focused on single cell analysis.
Max A. Müller, Dhaka R. Bhandari, Bernhard Spengler   +2 more
doaj   +1 more source

MALDI Mass Spectrometry Imaging: A Potential Game-Changer in a Modern Microbiology

Cells, 2022
Nowadays, matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS) is routinely implemented as the reference method for the swift and straightforward identification of microorganisms.
Maureen Feucherolles, Gilles Frache
doaj   +1 more source

Sodium doping and trapped ion mobility spectrometry improve lipid detection for novel MALDI-MSI analysis of oats.

Food Chemistry, 2023
Oat (Avena sativa L.) is an important cereal grain with a unique nutritional profile including a high proportion of lipids. Understanding lipid composition and distribution in oats is valuable for plant, food and nutritional research, and can be achieved
Wai C. D. Lau, Leigh Donnellan, Matthew T. Briggs, T. Rupasinghe, John C. Harris, Julie E Hayes, P. Hoffmann   +6 more
semanticscholar   +1 more source

A Proof of Concept to Bridge the Gap between Mass Spectrometry Imaging, Protein Identification and Relative Quantitation: MSI~LC-MS/MS-LF

Proteomes, 2016
Mass spectrometry imaging (MSI) is a powerful tool to visualize the spatial distribution of molecules on a tissue section. The main limitation of MALDI-MSI of proteins is the lack of direct identification.
Laëtitia Théron, Delphine Centeno, Cécile Coudy-Gandilhon, Estelle Pujos-Guillot, Thierry Astruc, Didier Rémond, Jean-Claude Barthelemy, Frédéric Roche, Léonard Feasson, Michel Hébraud, Daniel Béchet, Christophe Chambon   +11 more
doaj   +1 more source

Detection of early proteomic alterations in 5xFAD Alzheimer's disease neonatal mouse model via MALDI‐MSI

Alzheimer's & Dementia, 2023
Alzheimer's disease (AD) is a debilitating neurodegenerative disorder, characterized by memory deficit and dementia. AD is considered a multifactorial disorder where multiple processes like amyloid‐beta and tau accumulation, axonal degeneration, synaptic
Irep Uras, Merve Karayel-Basar, B. Sahin, A. Baykal   +3 more
semanticscholar   +1 more source

Mass Spectrometry Imaging as a Tool to Investigate Region Specific Lipid Alterations in Symptomatic Human Carotid Atherosclerotic Plaques

Metabolites, 2021
Atherosclerosis is characterized by fatty plaques in large and medium sized arteries. Their rupture can causes thrombi, occlusions of downstream vessels and adverse clinical events.
Francesco Greco, Laura Quercioli, Angela Pucci, Silvia Rocchiccioli, Mauro Ferrari, Fabio A. Recchia, Liam A. McDonnell   +6 more
doaj   +1 more source

Spatial resolution of renal amyloid deposits through MALDI-MSI: a combined digital and molecular approach to monoclonal gammopathies

Journal of Clinical Pathology, 2023
Aims Identification and characterisation of monoclonal gammopathies of renal significance (MGRS) is critical for therapeutic purposes. Amyloidosis represents one of the most common forms of MGRS, and renal biopsy remains the gold standard for their ...
Greta Bindi, Andrew Smith, G. Oliveira, A. Eccher, S. Vatrano, F. Alberici, G. Cazzaniga, S. Galimberti, G. Capitoli, F. Magni, F. Pagni, Vincenzo L’Imperio   +11 more
semanticscholar   +1 more source

Matrix-assisted laser desorption/ionisation mass spectrometry imaging and its development for plant protein imaging

Plant Methods, 2011
Matrix-Assisted Laser Desorption/Ionisation (MALDI) mass spectrometry imaging (MSI) uses the power of high mass resolution time of flight (ToF) mass spectrometry coupled to the raster of lasers shots across the cut surface of tissues to provide new ...
Millar A Harvey, Taylor Nicolas L, Grassl Julia   +2 more
doaj   +1 more source

Regional N-glycan and lipid analysis from tissues using MALDI-mass spectrometry imaging

STAR Protocols, 2021
Summary: N-glycans and lipids are structural metabolites that play important roles in cellular processes. Both show unique regional distribution in tissues; therefore, spatial analyses of these metabolites are crucial to our understanding of cellular ...
Alexandra E. Stanback, Lindsey R. Conroy, Lyndsay E.A. Young, Tara R. Hawkinson, Kia H. Markussen, Harrison A. Clarke, Derek B. Allison, Ramon C. Sun   +7 more
doaj   +1 more source