Results 61 to 70 of about 187,471 (221)

Statistical Modelling Investigation of MALDI-MSI-Based Approaches for Document Examination

Molecules, 2023
Questioned document examination aims to assess if a document of interest has been forged. Spectroscopy-based methods are the gold standard for this type of evaluation.
Johan Kjeldbjerg Lassen, Robert Bradshaw, Palle Villesen, Simona Francese   +3 more
doaj   +1 more source

Beyond the Fixed Charge: A New On‐Tissue Derivatisation Strategy Employing Photoionisable Chromophores for Mass Spectrometry Imaging of Amino‐Containing Metabolites

Angewandte Chemie, EarlyView.
We introduce a novel chemical derivatisation strategy for the UV‐activated detection of elusive metabolites. Incorporation of a tocopherol‐active chromophore allows for the detection of tagged analytes as photoionised radical cations, selectively induced by a 266 nm laser.
Sofia R. McGowan, Andrew J. Tague, Ashna A. Kumar, Marie Ranson, Christopher J. T. Hyland, Shane R. Ellis   +5 more
wiley   +2 more sources

Visualizing the spatial distribution and alteration of metabolites in continuously cropped Salvia miltiorrhiza Bge using MALDI-MSI

Journal of Pharmaceutical Analysis, 2021
Salvia miltiorrhiza Bge (SMB) has long been used in traditional Chinese medicine to treat cardiovascular and cerebrovascular diseases. Growing clinical usage has led to a huge demand for artificial planting of SMB.
Chenglong Sun, Li Cui, Bing-Qian Zhou, Xiao Wang, Lanping Guo, Wei Liu   +5 more
semanticscholar   +1 more source

Chemical composition of the fingermark residue: Assessment of the intravariability over one year using MALDI-MSI.

Forensic Science International, 2022
These past years, the chemical composition of fingermarks have attracted interest of researchers to meet multiple objectives like the determination of an individual's age, gender or lifestyle or the impact of some fingermark detection processes, to cite ...
M. Gorka, Aurélien Thomas, A. Bécue
semanticscholar   +1 more source

Multimodal Lung Cancer Subtyping Using Deep Learning Neural Networks on Whole Slide Tissue Images and MALDI MSI

Cancers, 2022
Simple Summary For the effective treatment of lung cancer patients, correct tumor subtyping is of utmost importance, but it is often challenging in clinical routine.
Charlotte Janßen, T. Boskamp, Jean Le'Clerc Arrastia, D. Otero Baguer, Lena Hauberg-Lotte, M. Kriegsmann, K. Kriegsmann, Georg Steinbuss, R. Casadonte, J. Kriegsmann, P. Maass   +10 more
semanticscholar   +1 more source

Drosophila melanogaster chemical ecology revisited: 2-D distribution maps of sex pheromones on whole virgin and mated flies by mass spectrometry imaging

BMC Zoology, 2020
Background Sexual behavior in Drosophila melanogaster flies is greatly influenced by chemical cues. In this study, a spatial distribution of female and male sex pheromones was investigated on the surface of virgin and mated six-day-old fruit flies ...
Filip Kaftan, Purva Kulkarni, Markus Knaden, Sebastian Böcker, Bill S. Hansson, Aleš Svatoš   +5 more
doaj   +1 more source

Correlating Mass Spectrometry Imaging and Liquid Chromatography-Tandem Mass Spectrometry for Tissue-Based Pharmacokinetic Studies

Metabolites, 2022
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a standard tool used for absolute quantification of drugs in pharmacokinetic (PK) studies.
Andreas Dannhorn, Emine Kazanc, Gregory Hamm, John G. Swales, Nicole Strittmatter, Gareth Maglennon, Richard J. A. Goodwin, Zoltan Takats   +7 more
doaj   +1 more source

Mapping of phospholipids by MALDI imaging (MALDI-MSI): realities and expectations [PDF]

Chemistry and Physics of Lipids, 2012
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) has emerged as a novel powerful MS methodology that has the ability to generate both molecular and spatial information within a tissue section. Application of this technology as a new type of biochemical lipid microscopy may lead to new discoveries of the lipid metabolism
Louis J, Sparvero, Andrew A, Amoscato, C Edward, Dixon, Joseph B, Long, Patrick M, Kochanek, Bruce R, Pitt, Hülya, Bayir, Valerian E, Kagan   +7 more
openaire   +2 more sources

Unraveling the drug distribution in brain enabled by MALDI MS imaging with laser-assisted chemical transfer

Acta Pharmaceutica Sinica B, 2022
Accurate localization of central nervous system (CNS) drug distribution in the brain is quite challenging to matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI), owing to the ionization competition/suppression of highly ...
Shuai Guo, Kening Li, Yanwen Chen, Bin Li   +3 more
doaj   +1 more source

MALDI-IHC-Guided In-Depth Spatial Proteomics: Targeted and Untargeted MSI Combined

, 2023
Recently, a novel technology was published, utilizing the strengths of matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) and immunohistochemistry (IHC), achieving highly multiplexed, targeted imaging of biomolecules in ...
Grgic, A., Heeren, Ron M. A., Britt S. R. Claes (11085021), Michiel Vandenbosch (14425444), Yagnik, G., Vandenbosch, M., Rothschild, K.J., Kasper K. Krestensen, Krestensen, Kasper K., Andrej Grgic, Kenneth J. Rothschild, Michiel Vandenbosch, Krestensen, K.K., Kuik, Christel, Mark J. Lim, Kasper K. Krestensen (14425435), Yagnik, Gargey, Claes, Britt S. R., Heeren, R.M.A., Lim, Mark J., Lim, M.J., Gargey Yagnik, Christel Kuik (14425441), Ron M. A. Heeren (7181636), Ron M. A. Heeren, Gargey Yagnik (1910416), Christel Kuik, Kenneth J. Rothschild (1324134), Andrej Grgic (14425438), Britt S. R. Claes, Vandenbosch, Michiel, Mark J. Lim (4814295), Claes, B.S.R., Grgic, Andrej, Kuik, C., Rothschild, Kenneth J.   +35 more
core   +1 more source