Results 71 to 80 of about 4,457 (177)

Spatiotemporal Metabolome and Single‐Nucleus Transcriptome Integration Illuminates an Auxin Gradient Orchestrated by NtTAC1 Underlying Leaf Angle Regulation in Tobacco

open access: yesPlant Biotechnology Journal, EarlyView.
Proposed model of TAC1‐mediated leaf angle regulation in tobacco. ABSTRACT Plant architecture is key to crop yield, with leaf angle being critical for high‐density cultivation. Although TAC1 represents a promising regulator of leaf angle for breeding, its molecular mechanism remains poorly understood, particularly at single‐nucleus resolution. Here, we
Lin Wang   +11 more
wiley   +1 more source

A Comparative Study of MALDI MSI Versus DESI MSI Applied to Questioned Document Examination

open access: yesRapid Communications in Mass Spectrometry, Volume 40, Issue 19, 15 October 2026.
ABSTRACT Rationale In forensic investigations, questioned document examination (QDE) provides critical information for document authentication and the detection of forgeries. Conventional QDE approaches often require separate analyses of inks and of any potential fingerprints.
Veronika Tibljas   +4 more
wiley   +1 more source

Enhancing IR‐MALDESI MSI Spatial Resolution Through Beam Constriction With a Ring‐Actuated Iris

open access: yesRapid Communications in Mass Spectrometry, Volume 40, Issue 16, 30 August 2026.
ABSTRACT Rationale Infrared matrix‐assisted laser desorption electrospray ionization (IR‐MALDESI) mass spectrometry imaging (MSI) enables label‐free, spatially resolved molecular analysis of biological tissues under ambient conditions. While improving spatial resolution is important for mapping fine tissue structures, mid‐infrared (IR) lasers are ...
Sarah M. Ashbacher   +6 more
wiley   +1 more source

Understanding Mass Spectrometry: From Ion Generation to Spectral Interpretation

open access: yesJournal of Mass Spectrometry, Volume 61, Issue 8, August 2026.
ABSTRACT This tutorial provides a structured introduction to mass spectrometry (MS), with particular emphasis on electrospray ionization (ESI)–based measurements. It is intended to support researchers from chemistry and related disciplines in developing a coherent understanding of MS principles, instrumentation, and data interpretation.
Arnold Steckel   +2 more
wiley   +1 more source

Innovations in MALDI MSI

open access: yes
This thesis focuses on the development of instruments and methods to improve mass spectrometry imaging (MSI). MSI enables simultaneous detection and localization of molecules in samples such as tissues or single cells. The ion source presented in this thesis improves spatial resolution in MSI experiments, enabling smaller pixel sizes. Coupling the mass
openaire   +2 more sources

Absorption and Effects of Patch Test Preparations of Hydroperoxides of Limonene and Hydroperoxides of Linalool in Human Ex Vivo Skin

open access: yesContact Dermatitis, Volume 95, Issue 2, Page 159-168, August 2026.
This study mimics clinical patch testing for the diagnosis of allergic contact dermatitis, by application of patch test preparations of fragrance terpenes to ex vivo human skin samples. The study investigates the penetration of linalool hydroperoxide and limonene hydroperoxide in skin, alongside an analysis of the lipid‐modifying effects of the patch ...
Aoife Clancy   +3 more
wiley   +1 more source

Advancing atherosclerosis research: The Power of lipid imaging with MALDI-MSI

open access: yesAtherosclerosis
Atherosclerosis is a chronic inflammatory disease that is one of the leading causes of mortality globally. It is characterized by the formation of atheromatous plaques in the intima layer of larger arteries. The (fibro-)fatty plaques usually develop asymptomatically within the vessel until a serious event such as myocardial infarction or stroke occurs.
Christoph H.M. Bookmeyer   +5 more
openaire   +3 more sources

Cross‐stage single‐cell and spatial metabolome analyses reveal periderm specialization and tanshinone biosynthesis in Salvia miltiorrhiza roots

open access: yesNew Phytologist, Volume 251, Issue 3, Page 1267-1282, August 2026.
Biosynthesis and accumulation of tanshinones in the periderm of Salvia miltiorrhiza during secondary root growth. Summary Perennial herbs develop long‐lived roots that undergo repeated cycles of secondary growth, during which the periderm functions as a protective barrier and a major site of specialized metabolite accumulation.
Licheng Liu   +19 more
wiley   +1 more source

Cutaneous squamous cell carcinoma characterized by MALDI mass spectrometry imaging in combination with machine learning

open access: yesScientific Reports
Cutaneous squamous cell carcinoma (SCC) is an increasingly prevalent global health concern. Current diagnostic and surgical methods are reliable, but they require considerable resources and do not provide metabolomic insight.
Lauritz F. Brorsen   +9 more
doaj   +1 more source

A Step‐by‐Step Protocol From METASPACE to Biological Interpretation

open access: yesJournal of Mass Spectrometry, Volume 61, Issue 7, July 2026.
ABSTRACT Mass spectrometry imaging (MSI) represents an exceptional tool for exploring complex biological systems spatially at the molecular level. However, its multidimensional nature and large data outputs make it challenging to extract meaningful biological insights. Advancements such as the METASPACE platform allow researchers to efficiently process,
Abigail Moreno‐Pedraza   +6 more
wiley   +1 more source

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