Results 91 to 100 of about 187,471 (221)

Spatially Resolved Metabolomics of Optimal Cutting Temperature (OCT) Compound‐Embedded Tumors

International Journal of Cancer, EarlyView.
ABSTRACT Mass spectrometry imaging (MSI) is emerging as a powerful tool for uncovering the distribution of metabolites in the tumor microenvironment and studying tumor metabolism in vivo. To date, MSI of biobanked tissues contextualized by patient data has been limited to peptides, proteins, and glycans—with few examples for metabolites.
Joseph Monaghan, Nicholas Woytowich, Tian Zhao, Kiera Nguyen, Emily Mahony, Julian J. Lum, Kyle D. Duncan   +6 more
wiley   +1 more source

MALDI-MSI Analysis of Cytological Smears: The Study of Thyroid Cancer

, 2017
Fine needle aspiration (FNA) biopsies are the current gold-standard for the preoperative evaluation of thyroid nodules. However, a significant number of them (15-30%) are unable to be affirmatively diagnosed and are given an "indeterminate for malignancy" final report, meaning that the malignant nature of the thyroid nodule remains unknown and the ...
Mosele, N, SMITH, ANDREW JAMES, GALLI, MANUEL, PAGNI, FABIO, MAGNI, FULVIO   +4 more
openaire   +2 more sources

Tumor classification with MALDI-MSI data of tissue microarrays: A case study

Methods, 2018
With mass spectrometry imaging (MSI) on tissue microarrays (TMAs) a large number of biomolecules can be studied for many patients at the same time, making it an attractive tool for biomarker discovery. Here we investigate whether lymph node metastasis can be predicted from MALDI-MSI data.
N.E. Mascini (Nadine), H.J. Teunissen (Jannis), R. Noorlag (Rob), S.M. Willems (Stefan), R.M.A. Heeren (Ron)   +4 more
openaire   +2 more sources

Integrated mass spectrometry imaging reveals spatial-metabolic alteration in diabetic cardiomyopathy and the intervention effects of ferulic acid

Journal of Pharmaceutical Analysis, 2023
Diabetic cardiomyopathy (DCM) is a metabolic disease and a leading cause of heart failure among people with diabetes. Mass spectrometry imaging (MSI) is a versatile technique capable of combining the molecular specificity of mass spectrometry (MS) with ...
Yanhua Liu, Xin Zhang, Shu Yang, Zhi Zhou, Lu Tian, Wanfang Li, Jinfeng Wei, Zeper Abliz, Zhonghua Wang   +8 more
doaj   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

MALDI-TOF Mass Spectrometry Discriminates Known Species and Marine Environmental Isolates of Pseudoalteromonas [PDF]

, 2016
The genus Pseudoalteromonas constitutes an ecologically significant group of marine Gammaproteobacteria with potential biotechnological value as producers of bioactive compounds and of enzymes.
Andrew Nelson, Caldwell, Gary S, Mesbahi, Ehsan, Green, DH, Emami, Kaveh, Caldwell, Gary, Caldwell, GS, Gary Stephen Caldwell, Hack, E, Jinwei eZhang, David H. Green, Kaveh Emami, Ethan Hack, Mesbahi, E, Nelson, Andrew, Caldwell, Gary S., Ethan eHack, Kaveh eEmami, Emami, K, Green, David, Ehsan Mesbahi, Nelson, A, Jinwei Zhang, Andrew eNelson, Gary S. Caldwell, Hack, Ethan, Zhang, Jinwei, David H Green, Green, David H., Ehsan eMesbahi, Zhang, J   +30 more
core   +1 more source

The Study of Derivatization Prior MALDI MSI Analysis—Charge Tagging Based on the Cholesterol and Betaine Aldehyde

Molecules, 2021
Mass spectrometry imaging is a powerful tool for analyzing the different kinds of molecules in tissue sections, but some substances cannot be measured easily, due to their physicochemical properties.
P. Mielczarek, Tymoteusz Słowik, J. Kotlinska, P. Suder, A. Bodzon-Kulakowska   +4 more
semanticscholar   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Investigation of protein induction in tumour vascular targeted strategies by MALDI MSI [PDF]

Methods, 2011
Characterising the protein signatures in tumours following vascular-targeted therapy will help determine both treatment response and resistance mechanisms. Here, mass spectrometry imaging and MS/MS with and without ion mobility separation have been used for this purpose in a mouse fibrosarcoma model following treatment with the tubulin-binding tumour ...
Cole, Laura, Djidja, M-C, Bluff, J., Claude, E, Carolan, Vikki, Paley, M, Tozer, G M, Clench, Malcolm   +7 more
openaire   +4 more sources

Mini Review: Highlight of Recent Advances and Applications of MALDI Mass Spectrometry Imaging in 2024

Analytical Science Advances
Matrix‐assisted laser desorption/ionisation mass spectrometry imaging (MALDI‐MSI) is an emerging imaging tool that allows visualisation of hundreds of analytes unbiasedly in a single experiment.
Yuen Tung Ngai, Darren Lau, Parul Mittal, Peter Hoffmann   +3 more
doaj   +1 more source