Results 111 to 120 of about 187,471 (221)

Application of Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging in Food Authenticity Assessment and Variety Identification [PDF]

Shipin Kexue
Food authenticity assessment and variety identification are crucial for ensuring food safety and protecting consumer rights. Traditional analytical techniques provide qualitative and quantitative information on target compounds, forming an essential ...
SHAO Zhenchao, PANG Bo, REN Yulong, DI Shuangshuang, LIAN Jie, NIE Honggang
doaj   +1 more source

Tissue‐Specific and Spatially Dependent Metabolic Signatures Perturbed by Injury in Male and Female Mice

Arthritis &Rheumatology, Volume 78, Issue 9, Page 1850-1862, September 2026.
Objective Osteoarthritis, the leading cause of disability worldwide, disproportionately affects women, yet sex remains an overlooked determinant. This disparity stems from sex‐specific differences in injury susceptibility—a major risk factor for disease.
Hope D. Welhaven, Avery H. Welfley, Priyanka P. Brahmachary, Mark Greenwood, Donald F. Smith, Brian Bothner, Ronald K. June   +6 more
wiley   +1 more source

Sample preparation of bone tissue for MALDI-MSI for forensic and (pre)clinical applications

Analytical and Bioanalytical Chemistry, 2020
In the past decades, matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) has been applied to a broad range of biological samples, e.g., forensics and preclinical samples.
M. Vandenbosch, Sylvia P. Nauta, A. Svirkova, M. Poeze, R. Heeren, T. Siegel, E. Cuypers, M. Marchetti‐Deschmann   +7 more
semanticscholar   +1 more source

Improving Proteolysis‐Targeting Chimera Delivery by Targeting Key Biomarkers in Tumor Endocytosis Pathways

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen, Jiayan Jiao, Huiling Yang, Tao He   +3 more
wiley   +1 more source

Quantification of 10B and 11B in Biological Samples in Translational Science and Clinical Applications for Boron Neutron Capture Therapy (BNCT)

Medicinal Research Reviews, Volume 46, Issue 5, Page 1362-1389, September 2026.
ABSTRACT Boron neutron capture therapy (BNCT) is a targeted radiotherapy that exploits the selective accumulation of the 10B isotope within tumors, followed by irradiation with low‐energy neutrons to induce high linear energy transfer particles with short path lengths, resulting in localized tumor cell destruction while sparing surrounding healthy ...
Christoph Selg, Wolfgang A. G. Sauerwein, Evamarie Hey‐Hawkins   +2 more
wiley   +1 more source

Mycotoxins in Basidiomycete Mycelium and Fruiting Bodies: Implications for Eu Novel Food Assessment and Selected International Regulatory Frameworks

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 5, September 2026.
ABSTRACT Advances in technology have enabled the efficient and sustainable production of basidiomycete vegetative mycelium, particularly from Pleurotus species, as a novel food source. However, mycelium has yet to receive regulatory approval in many global markets, requiring a better understanding of factors affecting its safety.
Niklas Erik Wilhelm Berglund, Pauliina Vappu Lankinen, Kirsi Susanna Mikkonen   +2 more
wiley   +1 more source

Innovations in MALDI MSI

This thesis focuses on the development of instruments and methods to improve mass spectrometry imaging (MSI). MSI enables simultaneous detection and localization of molecules in samples such as tissues or single cells. The ion source presented in this thesis improves spatial resolution in MSI experiments, enabling smaller pixel sizes. Coupling the mass
openaire   +2 more sources

Multi‐omics profiling of chronic immune‐mediated skin diseases: SKINERGY protocol and strategic evaluation

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 9, Page 1490-1501, September 2026.
The SKINERGY study will investigate six immune‐mediated inflammatory skin diseases through a nationwide collaboration across all Dutch university medical centres. Involving 720 patients and 120 healthy volunteers, it is aimed at generating a high‐quality dataset to identify biomarkers that enable personalized treatment strategies and improved disease ...
N. G. Koster, J. M. P. A. van den Reek, E. M. G. J. de Jong, S. van Beugen, A. I. M. van Laarhoven, I. Haeck, M. de Bruin‐Weller, M. L. Schuttelaar, B. Horvath, A. Gostyński, A. Knulst, M. H. Vermeer, L. Nguyen, L. Gerbens, P. Spuls, M. A. Middelkamp‐Hup, V. Exadaktylos, T. Niemeyer‐van der Kolk, A. R. Schrader, A. M. Sluijmers, J. Versteeg, B. W. M. Arents, I. van Ee, J. L. A. G. van der Zon, M. de Leeuw, T. de Leeuw, P. van den Broek, C. Berkhof, D. Vellinga, S. Weidinger, S. Dubrac, Y. Li, M. van Steensel, M. Marchetti‐Deschmann, M. Maurer, H. van der Zee, J. Damman, D. J. Hijnen, F. Wijk, M. M. B. Seyger, H. Röckmann, D. M. W. Balak, M. B. A. van Doorn, R. Rissmann, on behalf of The Next Generation ImmunoDermatology (NGID) consortium, Rob Vreeken, Eva Cuypers, Boudewijn Lelieveldt, Abdoel El Ghalbzouri, Hanna Niehues, Ellen van den Bogaard, Tom Ederveen, Els van der Pool, Nanda Olde, Debra Trampe, Ellen Stijl‐’t Hart, Lisanne Wezendonk, Johan Westerhuis, Huma Shehwana, Joerg Schreiber, Jeremy Bost, Mie Bech Lukassen, Jimmy Bakker, Juliette Simons, Fauve van den Berge, Colin Spence, Elise Beljaards, Anastasiia Myronenko, Mariona Oliver   +68 more
wiley   +1 more source

Cutaneous squamous cell carcinoma characterized by MALDI mass spectrometry imaging in combination with machine learning

Scientific Reports
Cutaneous squamous cell carcinoma (SCC) is an increasingly prevalent global health concern. Current diagnostic and surgical methods are reliable, but they require considerable resources and do not provide metabolomic insight.
Lauritz F. Brorsen, James S. McKenzie, Mette F. Tullin, Katja M. S. Bendtsen, Fernanda E. Pinto, Henrik E. Jensen, Merete Haedersdal, Zoltan Takats, Christian Janfelt, Catharina M. Lerche   +9 more
doaj   +1 more source

Impact of aging on neck vasculature and brain biochemistry in female mice

Physiological Reports, Volume 14, Issue 17, September 2026.
Abstract Age‐related changes in large‐vessel biomechanics may contribute to neurovascular dysfunction and region‐specific biochemical remodeling in the brain, with important implications for female health. This study investigated the impact of aging on neck vasculature and brain lipid biochemistry in female C57BL/6NHsd mice by comparing young (12 weeks;
Allison R. Jones, Amin Jarrahi, Kylee Karpowich, EllaGrey Moody, Lily Renner, Lindsay P. Brown, Caitlin M. Tressler, A. Colleen Crouch   +7 more
wiley   +1 more source