Results 121 to 130 of about 187,471 (221)

Enhancing IR‐MALDESI MSI Spatial Resolution Through Beam Constriction With a Ring‐Actuated Iris

Rapid Communications in Mass Spectrometry, Volume 40, Issue 16, 30 August 2026.
ABSTRACT Rationale Infrared matrix‐assisted laser desorption electrospray ionization (IR‐MALDESI) mass spectrometry imaging (MSI) enables label‐free, spatially resolved molecular analysis of biological tissues under ambient conditions. While improving spatial resolution is important for mapping fine tissue structures, mid‐infrared (IR) lasers are ...
Sarah M. Ashbacher, Seth M. Eisenberg, Alexander A. C. Wainwright, Aosheng Gu, Syeda N. Mahdia, R. J. Dwayne Miller, David C. Muddiman   +6 more
wiley   +1 more source

Dry Deposition Strategies for MALDI–MS Imaging: Principles, Advances and Emerging Applications

Analytical Science Advances
Matrix‐assisted laser desorption/ionisation mass spectrometry imaging (MALDI–MSI) has become a pivotal tool in biomedical research, enabling untargeted, spatially resolved analysis of molecular species in complex biological tissues.
Toufik Mahamdi, Oscar Yanes
doaj   +1 more source

Matrix-assisted laser desorption/ionization mass spectrometry imaging for quorum sensing

AMB Express
Quorum sensing (QS) is a complex communication system in bacteria, directing their response to the environment. QS is also one of the main regulators of bacterial biofilms’ formation, maturation and dispersion. Matrix-assisted laser desorption ionization
Christel Kuik, Sanne W.G. van Hoogstraten, Jacobus J.C. Arts, Maarten Honing, Berta Cillero-Pastor   +4 more
doaj   +1 more source

Advances in Single-Cell Mass Spectrometry Imaging for Small Molecule Analysis

Zhipu Xuebao
Mass spectrometry imaging (MSI) has emerged as a powerful technique for label-free molecular mapping in biological tissues, enabling spatial analysis of small molecules at the single-cell level.
Xiang MEI, Mu-ying-nan YOU, Guo-wang XU, Xin-yu LIU   +3 more
doaj   +1 more source

Combination of MALDI-MSI and cassette dosing for evaluation of drug distribution in human skin explant

, 2017
Study of skin penetration and distribution of the drug compounds in the skin is a major challenge in the development of topical drug products for treatment of skin diseases.
Janfelt, Christian, Nina Ø. Knudsen, Eriksson, André H, Christian Janfelt, Anders J. Pedersen, Knudsen, Nina Ø, Isabella S. Sørensen, Nielsen, Mette Marie B, Mortensen, Rasmus W, Mette Marie B. Nielsen, Nielsen, Kim T, Kim T. Nielsen, André H. Eriksson, Rasmus W. Mortensen, Sørensen, Isabella S, Pedersen, Anders J   +15 more
core   +1 more source

Application of MALDI-MSI for detection of antimicrobial peptides in tissues of the marine invertebrate Arenicola marina [PDF]

Invertebrate Survival Journal, 2016
Application of MALDI-MSI for detection of antimicrobial peptides in tissues of the marine invertebrate Arenicola marina AL Maltseva1 , VV Starunov1 , PA Zykin2 1 Department of Invertebrate Zoology, St Petersburg State University, St Petersburg ...
AL Maltseva, VV Starunov, PA Zykin
doaj  

MALDI-MSI Lipidomics of Lung Tissue v2

This protocol describes the procedure to obtain MALDI mass spectrometry images of lipids using a high mass resolution FTICR. This protocol is optimized for 12 µm sections of agarose-inflated and carboxymethyl cellulose-embedded fresh-frozen lung tissues. The embedding method is described in Lukowski et al.
Christopher R Anderton, Brittney Gorman
openaire   +1 more source

MALDI-MSI Lipidomics of Lung Tissue v1

This protocol describes the procedure to obtain MALDI mass spectrometry images of lipids using a high mass resolution FTICR. This protocol is optimized for 12 µm sections of agarose-inflated and carboxymethyl cellulose-embedded fresh-frozen lung tissues. The embedding method is described in Lukowski et al.
Christopher R Anderton, Brittney Gorman
openaire   +1 more source

A Quantitative MALDI-MSI Study of the Movement of Molecules in Biological Systems [PDF]

The use of mass spectrometry imaging (MSI) for the analysis of 3D tissue models of human skin has been shown to provide an elegant label-free methodology for the study of both drug absorption and drug biotransformation.
Russo, Cristina
core   +1 more source

An isotopically-labelled temporal mass spectrometry imaging data analysis workflow to reveal glucose spatial metabolism patterns in bovine lens tissue

Scientific Reports
Application of stable isotopically labelled (SIL) molecules in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging (MALDI-MSI) over a series of time points allows the temporal and spatial dynamics of biochemical reactions to be tracked ...
Dingchang Shi, Angus C. Grey, George Guo
doaj   +1 more source