Results 141 to 150 of about 4,457 (177)

MALDI-MSI: A potential game changer in forensic sciences

Forensic Science, Medicine, and Pathology
Matrix-assisted laser Desorption/Ionization Mass Spectrometry Imaging (MALDI MSI) is an analytical technique used for the spatial mapping of drugs, explosives, and organic samples, making it a game-changer in Forensic examination. It detects a wide range of biomolecules in their native state without specific tags, antibodies, labels, and dyes.
Asma, Jamshaid, Saadia, Noreen, Tanveer, Khalid   +2 more
exaly   +3 more sources

A Matrix Sublimation Device with an Integrated Solvent Nebulizer for MALDI-MSI

Journal of the American Society for Mass Spectrometry, 2021
The current matrix deposition methods in MALDI-mass spectrometry imaging (MALDI-MSI) face technical problems related to the inhomogeneous distribution of crystals and the low analyte extraction and cocrystallization efficiency. In this work, an integrated matrix sublimation device with synchronous solvent nebulization was developed for MALDI-MSI ...
Huizhi Li, Ri Wu, Qiongzheng Hu, Xiangfeng Chen, T.-W. Dominic Chan   +4 more
openaire   +2 more sources

Specific MALDI-MSI: TAG-MASS

2010
MALDI imaging as a molecular mass spectrometry imaging technique (MSI) can provide accurate information about molecular composition on a surface. The last decade of MSI development has brought the technology to clinical and biomedical applications as a complementary technique of MRI and other molecular imaging.
Jonathan, Stauber, Mohamed El, Ayed, Maxence, Wisztorski, Michel, Salzet, Isabelle, Fournier   +4 more
openaire   +2 more sources

Discriminator for Cutaneous Leishmaniasis Using MALDI-MSI in a Murine Model

Journal of the American Society for Mass Spectrometry, 2022
Cutaneous leishmaniasis is a skin disease caused by flagellate protozoa of the genus Leishmania and transmitted by sandflies of the genus Lutzomyia. Around 1 million new cases occur in the world annually, with a total of 12 million people affected, mainly in rural areas with low access to health services and adequate treatments.
Crisostomo Barajas-Solano, Betsy Muñoz, Eduardo Chicano-Gálvez, Patricia Escobar, Enrique Mejía-Ospino   +4 more
openaire   +2 more sources

MALDI-MSI of Lipids in Human Skin

2017
Matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS) is now a well-established technique for imaging analysis of sectioned biological tissues. One of the growing areas of interest is in the analysis of skin. MALDI-MSI can provide a wealth of information from within sections of skin. This includes information on the distribution of
Philippa J, Hart, Malcolm R, Clench
openaire   +2 more sources

Applications of MALDI-MSI to Pharmaceutical Research

2010
MALDI-MSI has been demonstrated to be a suitable technique in pharmaceutical research for providing information of the distribution of low molecular weight compounds such as drugs and their metabolites within whole-body tissue sections. Important ADME information can be determined by MALDI-MSI analysis of the distribution of drugs and metabolites in ...
Brendan, Prideaux, Dieter, Staab, Markus, Stoeckli   +2 more
openaire   +2 more sources

The putative role of MALDI-MSI in the study of Membranous Nephropathy

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2017
Membranous Nephropathy (MN) is an immunocomplex mediated renal disease that represents one of the most frequent glomerulopathies worldwide. This glomerular disease can manifest as primary (idiopathic) or secondary and this distinction is crucial when choosing the most appropriate course of treatment.
Smith, A, L'Imperio, V, Ajello, E, Ferrario, F, Mosele, N, Stella, M, Galli, M, Chinello, C, Pieruzzi, F, Spasovski, G, Pagni, F, Magni, F   +11 more
openaire   +3 more sources

Machine learning approaches in MALDI-MSI: clinical applications

Expert Review of Proteomics, 2016
Despite the unquestionable advantages of Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging in visualizing the spatial distribution and the relative abundance of biomolecules directly on-tissue, the yielded data is complex and high dimensional.
Manuel Galli, Italo Zoppis, Andrew Smith, Fulvio Magni, Giancarlo Mauri   +4 more
openaire   +2 more sources

Mapping of MeLiM melanoma combining ICP-MS and MALDI-MSI methods

International Journal of Biological Macromolecules, 2022
Here we developed a powerful tool for comprehensive data collection and mapping of molecular and elemental signatures in the Melanoma-bearing Libechov Minipig (MeLiM) model. The combination of different mass spectrometric methods allowed for detail investigation of specific melanoma markers and elements and their spatial distribution in tissue sections.
Vanickova L., Do T., Vejvodova M., Horak V., Hubalek M., Emri G., Zemankova K., Pavelicova K., Krizkova S., Faltusova V., Pompeiano A., Vaculovicova M., Zitka O., Vaculovic T., Adam V.   +14 more
openaire   +2 more sources

Critical Evaluation of Sphingolipids Detection by MALDI-MSI

ABSTRACT The increasing interest in the role of sphingolipids in (patho)physiology has led to the demand for visualization of these lipids within tissue samples (both from animal models and patient specimens) using techniques such as matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI).
Bo Chen, Ranjana Pathak, Albar Subekti, Xiaolu Cheng, Sukhjit Singh, Anne G. Ostermeyer-Fay, Yusuf A. Hannun, Chiara Luberto, Daniel Canals   +8 more
openaire   +2 more sources