Results 161 to 170 of about 95,119 (201)

Effects of Sex and Western Diet on Spatial Lipidomic Profiles for the Hippocampus, Cortex, and Corpus Callosum in Mice Using MALDI MSI. [PDF]

J Am Soc Mass Spectrom
Shafer CC, Di Lucente J, Mendiola UR, Maezawa I, Jin LW, Neumann EK.   +5 more
europepmc   +1 more source

MALDI-MSI of Lipids in Human Skin

Methods in Molecular Biology, 2017
Matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS) is now a well-established technique for imaging analysis of sectioned biological tissues. One of the growing areas of interest is in the analysis of skin.
Malcolm R. Clench
exaly   +4 more sources

The Use of MALDI-MSI in the Investigation of Psychiatric and Neurodegenerative Disorders: A Review [PDF]

Proteomics, 2016
First published: 17 May 2016Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a mass spectrometry technique used for the analysis of macromolecules on an intact tissue of interest, thereby allowing the assessment of ...
Bernhard Baune, Peter Hoffmann, Florian Weiland   +2 more
exaly   +6 more sources

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Specific MALDI-MSI: TAG-MASS

2010
MALDI imaging as a molecular mass spectrometry imaging technique (MSI) can provide accurate information about molecular composition on a surface. The last decade of MSI development has brought the technology to clinical and biomedical applications as a complementary technique of MRI and other molecular imaging.
Jonathan, Stauber, Mohamed El, Ayed, Maxence, Wisztorski, Michel, Salzet, Isabelle, Fournier   +4 more
openaire   +2 more sources

Applications of MALDI-MSI to Pharmaceutical Research

2010
MALDI-MSI has been demonstrated to be a suitable technique in pharmaceutical research for providing information of the distribution of low molecular weight compounds such as drugs and their metabolites within whole-body tissue sections. Important ADME information can be determined by MALDI-MSI analysis of the distribution of drugs and metabolites in ...
Brendan, Prideaux, Dieter, Staab, Markus, Stoeckli   +2 more
openaire   +2 more sources

Discriminator for Cutaneous Leishmaniasis Using MALDI-MSI in a Murine Model

Journal of the American Society for Mass Spectrometry, 2022
Cutaneous leishmaniasis is a skin disease caused by flagellate protozoa of the genus Leishmania and transmitted by sandflies of the genus Lutzomyia. Around 1 million new cases occur in the world annually, with a total of 12 million people affected, mainly in rural areas with low access to health services and adequate treatments.
Crisostomo Barajas-Solano, Betsy Muñoz, Eduardo Chicano-Gálvez, Patricia Escobar, Enrique Mejía-Ospino   +4 more
openaire   +2 more sources

The putative role of MALDI-MSI in the study of Membranous Nephropathy

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2017
Membranous Nephropathy (MN) is an immunocomplex mediated renal disease that represents one of the most frequent glomerulopathies worldwide. This glomerular disease can manifest as primary (idiopathic) or secondary and this distinction is crucial when choosing the most appropriate course of treatment.
Smith, A, L'Imperio, V, Ajello, E, Ferrario, F, Mosele, N, Stella, M, Galli, M, Chinello, C, Pieruzzi, F, Spasovski, G, Pagni, F, Magni, F   +11 more
openaire   +3 more sources

Machine learning approaches in MALDI-MSI: clinical applications

Expert Review of Proteomics, 2016
Despite the unquestionable advantages of Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging in visualizing the spatial distribution and the relative abundance of biomolecules directly on-tissue, the yielded data is complex and high dimensional.
Manuel Galli, Italo Zoppis, Andrew Smith, Fulvio Magni, Giancarlo Mauri   +4 more
openaire   +2 more sources

MALDI‐MSI: Insights Into Plant, Cell and Environment

Plant, Cell & Environment
Summary statement MALDI‐MSI overcomes the homogenization bottleneck of conventional omics by enabling the in situ visualization of metabolites while preserving native tissue architecture. This spatial perspective reveals metabolic heterogeneity, offering key insights into plant environment adaptation mechanisms.
Hua Guo, Ran Wu, Xiaodong Wang
openaire   +2 more sources

Mapping of MeLiM melanoma combining ICP-MS and MALDI-MSI methods

International Journal of Biological Macromolecules, 2022
Here we developed a powerful tool for comprehensive data collection and mapping of molecular and elemental signatures in the Melanoma-bearing Libechov Minipig (MeLiM) model. The combination of different mass spectrometric methods allowed for detail investigation of specific melanoma markers and elements and their spatial distribution in tissue sections.
Vanickova L., Do T., Vejvodova M., Horak V., Hubalek M., Emri G., Zemankova K., Pavelicova K., Krizkova S., Faltusova V., Pompeiano A., Vaculovicova M., Zitka O., Vaculovic T., Adam V.   +14 more
openaire   +2 more sources