Results 181 to 190 of about 187,471 (221)
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MALDI-MSI analysis of cancer drugs: Significance, advances, and applications
TrAC - Trends in Analytical Chemistry, 2021Because of the heterogeneity and complexity of tumor structure, cancer drugs often cannot effectively reach the tumor, which is one of the reasons for drug resistance and treatment failure.
Cuirong Sun, Quan He
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Metabolites, 2021 The association between lipid metabolism and long-term outcomes is relevant for tumor diagnosis and therapy. Archival material such as formalin-fixed and paraffin embedded (FFPE) tissues is a highly valuable resource for this aim as it is linked to long ...
Anna Nordborg, Vanna Denti
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Journal of Agricultural and Food Chemistry, 2023
Stilbene phytoalexins are among the most accumulated compounds during grapevine-pathogen interactions. However, their steady-state accumulation level and spatial distribution within the tissues to counteract Botrytis cinerea infection remain to be ...
Marisa Maia +3 more
semanticscholar +1 more source
Stilbene phytoalexins are among the most accumulated compounds during grapevine-pathogen interactions. However, their steady-state accumulation level and spatial distribution within the tissues to counteract Botrytis cinerea infection remain to be ...
Marisa Maia +3 more
semanticscholar +1 more source
In-situ detection and imaging of Areca catechu fruit alkaloids by MALDI-MSI
Industrial Crops and Products, 2022Yinglang Wan, Hongwei Zhao
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Journal of the American Society for Mass Spectrometry, 2022
Investigation of the spatial distribution of N-glycans in tissue specimens has emerged as a powerful tool in clinical research, in part, because altered N-glycans are often a hallmark of disease progression.
D. Veličković +4 more
semanticscholar +1 more source
Investigation of the spatial distribution of N-glycans in tissue specimens has emerged as a powerful tool in clinical research, in part, because altered N-glycans are often a hallmark of disease progression.
D. Veličković +4 more
semanticscholar +1 more source
2010
MALDI imaging as a molecular mass spectrometry imaging technique (MSI) can provide accurate information about molecular composition on a surface. The last decade of MSI development has brought the technology to clinical and biomedical applications as a complementary technique of MRI and other molecular imaging.
Jonathan, Stauber +4 more
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MALDI imaging as a molecular mass spectrometry imaging technique (MSI) can provide accurate information about molecular composition on a surface. The last decade of MSI development has brought the technology to clinical and biomedical applications as a complementary technique of MRI and other molecular imaging.
Jonathan, Stauber +4 more
openaire +2 more sources
Applications of MALDI-MSI to Pharmaceutical Research
2010MALDI-MSI has been demonstrated to be a suitable technique in pharmaceutical research for providing information of the distribution of low molecular weight compounds such as drugs and their metabolites within whole-body tissue sections. Important ADME information can be determined by MALDI-MSI analysis of the distribution of drugs and metabolites in ...
Brendan, Prideaux +2 more
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The putative role of MALDI-MSI in the study of Membranous Nephropathy
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2017Membranous Nephropathy (MN) is an immunocomplex mediated renal disease that represents one of the most frequent glomerulopathies worldwide. This glomerular disease can manifest as primary (idiopathic) or secondary and this distinction is crucial when choosing the most appropriate course of treatment.
Smith, A +11 more
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Discriminator for Cutaneous Leishmaniasis Using MALDI-MSI in a Murine Model
Journal of the American Society for Mass Spectrometry, 2022Cutaneous leishmaniasis is a skin disease caused by flagellate protozoa of the genus Leishmania and transmitted by sandflies of the genus Lutzomyia. Around 1 million new cases occur in the world annually, with a total of 12 million people affected, mainly in rural areas with low access to health services and adequate treatments.
Crisostomo Barajas-Solano +4 more
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Machine learning approaches in MALDI-MSI: clinical applications
Expert Review of Proteomics, 2016Despite the unquestionable advantages of Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging in visualizing the spatial distribution and the relative abundance of biomolecules directly on-tissue, the yielded data is complex and high dimensional.
Manuel Galli +4 more
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