Results 191 to 200 of about 187,471 (221)

Single-Cell Multiomic MALDI-MSI Analysis of Lipids and N-Glycans through Affinity Array Capture.

Analytical Chemistry
This study presents a novel approach utilizing matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) for rapid single-cell analysis, enabling multiomic data acquisition from the same cell. Previously, single-cell approaches by
James W Dressman, M. F. Bayram, P. Angel, Richard R. Drake, Anand S. Mehta   +4 more
semanticscholar   +1 more source

Developing CHCA/PPD as a Novel Matrix for Enhanced MALDI-MSI for Analysis of Antibiotics in Grass Carp Tissues.

Rapid Communications in Mass Spectrometry, 2022
RATIONALE Antibiotics have important medical value, but they need to be monitored when used as veterinary drugs. We report α-cyano-4-hydroxycinnamic acid/p-phenylenediamine (CHCA/PPD) hybrid as a novel matrix for enhanced matrix-assisted laser desorption/
Xin Qiu, Fengming Chen, Tong Liu, F. Feng, Yuan Zhang, Xue-song Feng, Feng Zhang   +6 more
semanticscholar   +1 more source

Towards developing a matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) compatible tissue expansion protocol.

Analytica Chimica Acta
Mass spectrometry imaging (MSI) visualizes spatial distribution of molecules in a biological tissue. However, compared with traditional microscopy-based imaging, conventional MSI is limited to its spatial resolution, resulting in difficulties in ...
Li-Cyun Chen, Chuping Lee, Cheng-Chih Hsu   +2 more
semanticscholar   +1 more source

Mapping of MeLiM melanoma combining ICP-MS and MALDI-MSI methods

International Journal of Biological Macromolecules, 2022
Here we developed a powerful tool for comprehensive data collection and mapping of molecular and elemental signatures in the Melanoma-bearing Libechov Minipig (MeLiM) model. The combination of different mass spectrometric methods allowed for detail investigation of specific melanoma markers and elements and their spatial distribution in tissue sections.
Vanickova L., Do T., Vejvodova M., Horak V., Hubalek M., Emri G., Zemankova K., Pavelicova K., Krizkova S., Faltusova V., Pompeiano A., Vaculovicova M., Zitka O., Vaculovic T., Adam V.   +14 more
openaire   +2 more sources

Electromagnetic Field-Assisted Frozen Tissue Planarization Enhances MALDI-MSI in Plant Spatial Omics.

Analytical Chemistry
Plant samples with irregular morphology are challenging for longitudinal tissue sectioning. This has restricted the ability to gain insight into some plants using matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI).
Hao Hu, Kaidi Qiu, Qichen Hao, Xiaojia He, Liang Qin, Lulu Chen, Chenyu Yang, X. Dai, Haiqiang Liu, Hualei Xu, Hua Guo, Jinrong Li, Ran Wu, Jinchao Feng, Yijun Zhou, Jun Han, Chun Xiao, Xiaodong Wang   +17 more
semanticscholar   +1 more source

Introducing FISCAS, a Tool for the Effective Generation of Single Cell MALDI-MSI Data.

Journal of the American Society for Mass Spectrometry
We introduce Fluorescence Integrated Single-Cell Analysis Script (FISCAS), which combines fluorescence microscopy with MALDI-MSI to streamline single-cell analysis.
Jan Schwenzfeier, Sarah Weischer, S. Bessler, Jens Soltwisch   +3 more
semanticscholar   +1 more source

Critical Evaluation of Sphingolipids Detection by MALDI-MSI

ABSTRACT The increasing interest in the role of sphingolipids in (patho)physiology has led to the demand for visualization of these lipids within tissue samples (both from animal models and patient specimens) using techniques such as matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI).
Bo Chen, Ranjana Pathak, Albar Subekti, Xiaolu Cheng, Sukhjit Singh, Anne G. Ostermeyer-Fay, Yusuf A. Hannun, Chiara Luberto, Daniel Canals   +8 more
openaire   +2 more sources

Visualization of single-cell lipidomes with MALDI-MSI

Lipids are central to cellular structure, metabolism, and signaling, and yet their distribution within and across cells is highly heterogeneous. Traditional bulk mass spectrometry masks this diversity, whereas single-cell lipidomics can uncover distinct lipid configurations that define cellular states and organize tissues.
Maillat, Jean Andrea, Goršek, Nika, Barahtjan, Pavel, D'Angelo, Giovanni   +3 more
openaire   +2 more sources

Recent Technological Developments in MALDI-MSI Based Hair Analysis

2019
Hair is a common piece of trace evidence found at a crime scene, however, often it is not possible to obtain DNA (due to the lack of a follicular root). These hair samples could potentially provide other intelligence, based on the molecular history of an individual that it contains.
Flinders, Bryn, Bassindale, Tom, Heeren, Ron   +2 more
openaire   +2 more sources

Tissue MALDI Mass Spectrometry Imaging (MALDI MSI) of Peptides

2015
Matrix assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) is a technique to visualize molecular features of tissues based on mass detection. This chapter focuses on MALDI MSI of peptides and provides detailed operational instructions for sample preparation of cryoconserved and formalin-fixed paraffin-embedded (FFPE) tissue ...
Birte, Beine, Hanna C, Diehl, Helmut E, Meyer, Corinna, Henkel   +3 more
openaire   +2 more sources