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MALDI-MSI: A Potential Game Changer in Forensic Sciences
Forensic Science, Medicine, and PathologyMatrix-assisted laser Desorption/Ionization Mass Spectrometry Imaging (MALDI MSI) is an analytical technique used for the spatial mapping of drugs, explosives, and organic samples, making it a game-changer in Forensic examination. It detects a wide range of biomolecules in their native state without specific tags, antibodies, labels, and dyes.
Asma, Jamshaid +2 more
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Critical Evaluation of Sphingolipids Detection by MALDI-MSI
ABSTRACT The increasing interest in the role of sphingolipids in (patho)physiology has led to the demand for visualization of these lipids within tissue samples (both from animal models and patient specimens) using techniques such as matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI).Bo Chen +8 more
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Visualization of single-cell lipidomes with MALDI-MSI
Lipids are central to cellular structure, metabolism, and signaling, and yet their distribution within and across cells is highly heterogeneous. Traditional bulk mass spectrometry masks this diversity, whereas single-cell lipidomics can uncover distinct lipid configurations that define cellular states and organize tissues.Maillat, Jean Andrea +3 more
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Recent Technological Developments in MALDI-MSI Based Hair Analysis
2019Hair is a common piece of trace evidence found at a crime scene, however, often it is not possible to obtain DNA (due to the lack of a follicular root). These hair samples could potentially provide other intelligence, based on the molecular history of an individual that it contains.
Flinders, Bryn +2 more
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Tissue MALDI Mass Spectrometry Imaging (MALDI MSI) of Peptides
2015Matrix assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) is a technique to visualize molecular features of tissues based on mass detection. This chapter focuses on MALDI MSI of peptides and provides detailed operational instructions for sample preparation of cryoconserved and formalin-fixed paraffin-embedded (FFPE) tissue ...
Birte, Beine +3 more
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Efficiency of the dry–wet method for the MALDI‐MSI analysis of latent fingermarks
Journal of Mass Spectrometry, 2013ABSTRACTMatrix‐assisted laser desorption/ionisation mass spectrometry imaging (MALDI‐MSI) has proven to be a powerful analytical tool to investigate problems in several fields of life science. A novel application is in the field of forensics, particularly in the analysis of latent fingermarks.
Leesa S, Ferguson +4 more
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Recent Advances in On‐Tissue Chemical Derivatization Strategies for Enhancing MALDI‐MSI
Mass Spectrometry ReviewsABSTRACT Matrix‐assisted laser desorption/ionization mass spectrometry imaging (MALDI‐MSI) has rapidly advanced in biomedical research, enabling label‐free, untargeted spatial detection of metabolites, lipids, proteins, and glycans in tissue sections. However, challenges such as low ionization efficiency and chemical instability limit
Meng Huang +10 more
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MALDI-MSI zeigt EVAR-induzierte Aortenwandinstabilität
Gefässchirurgie, 2022Matthias Buerger +9 more
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System klasyfikacji danych obrazowania molekularnego MALDI-MSI [PDF]
, 2022 Pendziałek, Paweł, Polańska, Joanna
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N-Glycan MALDI MSI Differentiates Kidney Glomerular Disease Phenotypes
Journal of the American Society for Mass SpectrometryAbstract Lupus nephritis (LN) and diabetic nephropathy (DN) are leading causes of kidney failure, characterized by distinct yet overlapping patterns of glomerular injury. While histopathology remains central to diagnosis, it provides limited insight into the underlying molecular remodeling.
Aaron O. Angerstein +5 more
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