Results 51 to 60 of about 4,457 (177)

Lipidomic Typing of Colorectal Cancer Tissue Containing Tumour-Infiltrating Lymphocytes by MALDI Mass Spectrometry Imaging

Metabolites, 2021
Predicting the prognosis of colorectal cancer (CRC) patients remains challenging and a characterisation of the tumour immune environment represents one of the most crucial avenues when attempting to do so.
Vanna Denti, Allia Mahajneh, Giulia Capitoli, Francesca Clerici, Isabella Piga, Lisa Pagani, Clizia Chinello, Maddalena Maria Bolognesi, Giuseppe Paglia, Stefania Galimberti, Fulvio Magni, Andrew Smith   +11 more
doaj   +1 more source

Tumor classification with MALDI-MSI data of tissue microarrays: A case study

Methods, 2018
With mass spectrometry imaging (MSI) on tissue microarrays (TMAs) a large number of biomolecules can be studied for many patients at the same time, making it an attractive tool for biomarker discovery. Here we investigate whether lymph node metastasis can be predicted from MALDI-MSI data.
N.E. Mascini (Nadine), H.J. Teunissen (Jannis), R. Noorlag (Rob), S.M. Willems (Stefan), R.M.A. Heeren (Ron)   +4 more
openaire   +2 more sources

Tissue‐Specific and Spatially Dependent Metabolic Signatures Perturbed by Injury in Male and Female Mice

Arthritis &Rheumatology, EarlyView.
Objective Osteoarthritis, the leading cause of disability worldwide, disproportionately affects women, yet sex remains an overlooked determinant. This disparity stems from sex‐specific differences in injury susceptibility—a major risk factor for disease.
Hope D. Welhaven, Avery H. Welfley, Priyanka P. Brahmachary, Mark Greenwood, Donald F. Smith, Brian Bothner, Ronald K. June   +6 more
wiley   +1 more source

Integrated mass spectrometry imaging reveals spatial-metabolic alteration in diabetic cardiomyopathy and the intervention effects of ferulic acid

Journal of Pharmaceutical Analysis, 2023
Diabetic cardiomyopathy (DCM) is a metabolic disease and a leading cause of heart failure among people with diabetes. Mass spectrometry imaging (MSI) is a versatile technique capable of combining the molecular specificity of mass spectrometry (MS) with ...
Yanhua Liu, Xin Zhang, Shu Yang, Zhi Zhou, Lu Tian, Wanfang Li, Jinfeng Wei, Zeper Abliz, Zhonghua Wang   +8 more
doaj   +1 more source

MALDI-MSI Analysis of Cytological Smears: The Study of Thyroid Cancer

, 2017
Fine needle aspiration (FNA) biopsies are the current gold-standard for the preoperative evaluation of thyroid nodules. However, a significant number of them (15-30%) are unable to be affirmatively diagnosed and are given an "indeterminate for malignancy" final report, meaning that the malignant nature of the thyroid nodule remains unknown and the ...
Mosele, N, SMITH, ANDREW JAMES, GALLI, MANUEL, PAGNI, FABIO, MAGNI, FULVIO   +4 more
openaire   +2 more sources

Chemistry Underlying the Behavior of Food and Agricultural Components During Industrial Manufacturing Processes and Its Implications in Quality Assurance, Food Quality, and Food Safety Management: A Systematic Review

Food Safety and Health, EarlyView.
Industrial manufacturing processes have transformative effects on the components of food matrix. These transformations in food matrix and components have direct implications for quality assurance (QA), food quality (e.g., nutritional profile and texture), and food safety management (e.g., pathogen control and toxin mitigation). ABSTRACT This systematic
Chinaza Godswill Awuchi
wiley   +1 more source

Spatial omics in the AI era: Technologies, algorithmic ecosystems, biological applications, and large model perspectives

iMeta, EarlyView.
This review focuses on spatial omics, covering the introduction and comparison of technology platforms, explanation and recommendation of algorithm ecology, demonstration of biological applications, and prospect of large models. It aims to help researchers in the interdisciplinary field of spatial omics quickly understand the current situation and ...
Haoxiu Wang, Xinwang Yang, Siheng Wang, Zhe Yang, Xiuhui Yang, Yutong Yang, Zirong Li, Yuqi Ren, Qianqian Zhang, Bowen Zhao, Jingming Xiao, Yidong Wang, Junhao Dong, Zhenhao Kou, Jie Li, Liqun Yang, Erhu Zhao, Gregory Fonseca, Ruibang Luo, Mingyu Yang, Hongjuan Cui, Gengjie Jia, Dan Wang, Haoyang Li, Jun Ding, Zhiyuan Yuan, Haojing Shao   +26 more
wiley   +1 more source

Visualizing the distribution of flavonoids in litchi (Litchi chinenis) seeds through matrix-assisted laser desorption/ionization mass spectrometry imaging

Frontiers in Plant Science, 2023
Flavonoids are one of the most important bioactive components in litchi (Litchi chinensis Sonn.) seeds and have broad-spectrum antiviral and antitumor activities.
Yukun Liu, Xiaofei Nie, Jilong Wang, Zhenqi Zhao, Zhimei Wang, Fang Ju   +5 more
doaj   +1 more source

Investigation of protein induction in tumour vascular targeted strategies by MALDI MSI [PDF]

Methods, 2011
Characterising the protein signatures in tumours following vascular-targeted therapy will help determine both treatment response and resistance mechanisms. Here, mass spectrometry imaging and MS/MS with and without ion mobility separation have been used for this purpose in a mouse fibrosarcoma model following treatment with the tubulin-binding tumour ...
Cole, Laura, Djidja, M-C, Bluff, J., Claude, E, Carolan, Vikki, Paley, M, Tozer, G M, Clench, Malcolm   +7 more
openaire   +4 more sources

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source