Results 61 to 70 of about 345,762 (348)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A novel methodology for in vivo endoscopic phenotyping of colorectal cancer based on real-time analysis of the mucosal lipidome: a prospective observational study of the iKnife [PDF]

, 2016
Background: This pilot study assessed the diagnostic accuracy of rapid evaporative ionization mass spectrometry (REIMS) in colorectal cancer (CRC) and colonic adenomas. Methods: Patients undergoing elective surgical resection for CRC were recruited at St.
Alexander, J, Balog, J, Darzi, A, Gildea, L, Goldin, R, Hoare, J, Kinross, J, Kontovounisios, C, McKenzie, J, Muirhead, L, Nicholson, J, Rasheed, S, Scott, A, Speller, A, Takats, Z, Teare, J, Tekkis, P, Veselkov, K   +17 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Characterization of NAC Gene Family in Ammopiptanthus mongolicus and Functional Analysis of AmNAC24, an Osmotic and Cold-Stress-Induced NAC Gene

Biomolecules
The NAC family of transcription factors (TFs) is recognized as a significant group within the plant kingdom, contributing crucially to managing growth and development processes in plants, as well as to their response and adaptation to various ...
Tashi Dorjee, Yican Cui, Yuxin Zhang, Qi Liu, Xuting Li, Batu Sumbur, Hongxi Yan, Jie Bing, Yuke Geng, Yijun Zhou, Fei Gao   +10 more
doaj   +1 more source

Both age and social environment shape the phenotype of ant workers

Scientific Reports, 2023
Position within the social group has consequences on individual lifespans in diverse taxa. This is especially obvious in eusocial insects, where workers differ in both the tasks they perform and their aging rates.
Martin Quque, Charlotte Brun, Claire Villette, Cédric Sueur, François Criscuolo, Dimitri Heintz, Fabrice Bertile   +6 more
doaj   +1 more source

Tumour cell labelling by magnetic nanoparticles with determination of intracellular iron content and spatial distribution of the intracellular iron [PDF]

, 2013
: Magnetically labelled cells are used for in vivo cell tracking by MRI, used for the clinical translation of cell-base therapies. Studies involving magnetic labelled cells may include separation of labelled cells, targeted delivery and controlled ...
Alexiou, Alexiou, Alfred Cuschieri, Amemiya, Brekke, Buerli, Bulte, Bulte, Corot, Foster, Frank, Frimpong, Furlani, Hong, Hoskins, Huberman, Ivkov, Jiang, Kamau, Lee, Lewin, Liu, Matuszewski, Mykhaylyk, Oudkerk, Park, Pinkse, Prentice, Riemer, Shen, Sun, Sykova, Thorek, Walczak, Wang, Wang, Wu, Zhang, Zhang, Zhang, Zhigang Wang, Zhu   +41 more
core   +5 more sources

Spatial Autocorrelation in Mass Spectrometry Imaging

Analytical Chemistry, 2016
Mass spectrometry imaging (MSI) is a powerful molecular imaging technique. In microprobe MSI, images are created through a grid-wise interrogation of individual spots by mass spectrometry across a surface. Classical statistical tests for within-sample comparisons fail as close-by measurement spots violate the assumption of independence of these tests ...
Cassese, A., Ellis, S.R., Potocnik, N.O., Burgermeister, E., Eber, M., Walch, A., Maagdenberg, A.M.J.M. van den, McDonnell, L.A., Heeren, R.M.A., Balluff, B.   +9 more
openaire   +6 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Spatially Resolved Immunometabolism to Understand Infectious Disease Progression

Frontiers in Microbiology, 2021
Infectious diseases, including those of viral, bacterial, fungal, and parasitic origin are often characterized by focal inflammation occurring in one or more distinct tissues.
Roel Tans, Shoumit Dey, Nidhi Sharma Dey, Grant Calder, Peter O’Toole, Paul M. Kaye, Ron M. A. Heeren   +6 more
doaj   +1 more source

On the importance of color in mass spectrometry imaging

Journal of Mass Spectrometry, 2022
Abstract Mass spectrometry imaging (MSI) data visualization relies on heatmaps to show the spatial distribution and measured abundances of molecules within a sample. Nonuniform color gradients such as jet are still commonly used to visualize MSI data, increasing the ...
Kevan T. Knizner, Russell R. Kibbe, Kenneth P. Garrard, Jamie R. Nuñez, Christopher R. Anderton, David C. Muddiman   +5 more
openaire   +2 more sources