Results 81 to 90 of about 5,293,958 (301)

Adaptive pixel mass recalibration for mass spectrometry imaging based on locally endogenous biological signals. [PDF]

, 2020
Mass spectrometry imaging (MSI) is a powerful and convenient method for revealing the spatial chemical composition of different biological samples. Molecular annotation of the detected signals is only possible if a high mass accuracy is maintained over ...
Mathieu, Tiquet, Lachlan, Stuart, Theodore, Alexandrov, Loïc, Quinton, Raphaël, La Rocca, Edwin, De Pauw, Christopher, Kune, Gauthier, Eppe   +7 more
core   +2 more sources

Geographic Variation and Quality Consistency of Toddaliae Asiaticae Radix: A Hybrid Framework Integrating Environmental Feature and Bioactivity-Weighted Modeling

Metabolites
Background: Toddaliae Asiaticae Radix (TA) boasts a long history of medicinal application. However, origin traceability and quality assessment of the widely distributed original plant Toddalia asiatica have not been fully elucidated.
Linjiang Wei, Hong Chen, Mengmeng Sun, Yuanle Song, Chen Zhang, Zhi Zhou   +5 more
doaj   +1 more source

In situ localization of micropollutants and associated stress response in Populus nigra leaves

Environment International, 2019
Micropollutants and emerging organic contaminants (EOCs) have been widely studied in terms of persistance, removal, human risk assessment, toxicology, etc. Mass spectrometry imaging (MSI) offers the possibility of following the fate of a single pesticide
C. Villette, L. Maurer, J. Delecolle, J. Zumsteg, M. Erhardt, D. Heintz   +5 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Assessment of genome packaging in AAVs using Orbitrap-based charge-detection mass spectrometry [PDF]

, 2022
Adeno-associated viruses (AAVs) represent important gene therapy vectors with several approved clinical applications and numerous more in clinical trials.
Friese, Olga, Heck, Albert J R, Powers, Thomas, Snijder, Joost, Wörner, Tobias P, Sub Biomol.Mass Spectrometry & Proteom., Biomolecular Mass Spectrometry and Proteomics, Afd Biomol.Mass Spect. and Proteomics   +7 more
core  

Mass spectrometry in environmental organic analysis

, 2022
S.406-415The use of mass spectrometry in environmental analysis is reviewed with special emphasis on modern mass spectrometric methods.
Levsen, K.
core   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Mass Spectrometry Imaging proves differential absorption profiles of well-characterised permeability markers along the crypt-villus axis

Scientific Reports, 2017
Knowledge about the region-specific absorption profiles from the gastrointestinal tract of orally administered drugs is a critical factor guiding dosage form selection in drug development.
Anna Nilsson, Alexandra Peric, Marie Strimfors, Richard J. A. Goodwin, Martin A. Hayes, Per E. Andrén, Constanze Hilgendorf   +6 more
doaj   +1 more source

Cyclotide host-defense tailored for species and environments in violets from the Canary Islands

Scientific Reports, 2021
Cyclotides are cyclic peptides produced by plants. Due to their insecticidal properties, they are thought to be involved in host defense. Violets produce complex mixtures of cyclotides, that are characteristic for each species and variable in different ...
Blazej Slazak, Klara Kaltenböck, Karin Steffen, Martyna Rogala, Priscila Rodríguez-Rodríguez, Anna Nilsson, Reza Shariatgorji, Per E. Andrén, Ulf Göransson   +8 more
doaj   +1 more source