Results 91 to 100 of about 345,762 (348)

Norm-SVR for the Enhancement of Single-Cell Metabolomic Stability in ToF-SIMS

Metabolites
Purpose: Data stability is a critical factor in Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) single-cell analysis. However, various factors, such as sample processing, instrument condition, and data acquisition, can introduce uncertainties ...
Mingru Liu, Hongzhe Ma, Xiang Fang, Yanhua Chen, Zhaoying Wang, Xiaoxiao Ma   +5 more
doaj   +1 more source

Spatial control of Draper receptor signaling initiates apoptotic cell engulfment. [PDF]

, 2017
The engulfment of apoptotic cells is essential for tissue homeostasis and recovering from damage. Engulfment is mediated by receptors that recognize ligands exposed on apoptotic cells such as phosphatidylserine (PS).
Adam P. Williamson, Arandjelovic, Bunnell, Burroughs, Carbone, Cherbas, Choudhuri, Cordoba, Davis, Dawson, DeMond, Edelstein, Elliott, Erlandson, Etchegaray, Fadok, Freeman, Freeman, Freeman, Fujita, Hui, Iram, James, Kaizuka, Kawano, Kuraishi, Kurant, Leventis, Lewis, Lim, Lu, MacDonald, Manaka, Mayer, Morrissey, Murugesan, Nagaosa, Neumann, Okada, Pellicena, Ravichandran, Reddien, Ronald D. Vale, Scheib, Schlam, Schmid, Schneider, Segawa, Stinchcombe, Tung, Yamauchi, Yi, Zhang, Zhou, Ziegenfuss, Ziegenfuss   +55 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Imaging surface plasmon resonance for multiplex microassay sensing of mycotoxins [PDF]

, 2011
A prototype imaging surface plasmon resonance-based multiplex microimmunoassay for mycotoxins is described. A microarray of mycotoxin–protein conjugates was fabricated using a continuous flow microspotter device.
Dorokhin, D., Franssen, M.C.R., Haasnoot, W., Nielen, M.W.F., Zuilhof, H.   +4 more
core   +3 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Striatal Tyrosine Hydroxylase Is Stimulated via TAAR1 by 3-Iodothyronamine, But Not by Tyramine or β-Phenylethylamine

Frontiers in Pharmacology, 2018
The trace amine-associated receptor 1 (TAAR1) is expressed by dopaminergic neurons, but the precise influence of trace amines upon their functional activity remains to be fully characterized.
Xiaoqun Zhang, Ioannis Mantas, Alexandra Alvarsson, Takashi Yoshitake, Mohammadreza Shariatgorji, Marcela Pereira, Anna Nilsson, Jan Kehr, Per E. Andrén, Mark J. Millan, Karima Chergui, Per Svenningsson   +11 more
doaj   +1 more source

Impact of wavelength and spot size on laser depth of focus: Considerations for mass spectrometry imaging of non‐flat samples By Alena N. Joignant, Ying Xi and David C. Muddiman [PDF]

, 2023
Alena N. Joignant, Ying Xi, David C. Muddiman   +2 more
openalex   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

ToF-SIMS Imaging for the Analysis of Cholesterol Formation at Macrophage Membrane

Metabolites
Background/Objectives: Atherosclerosis has its development intricately linked to cholesterol accumulation in the artery wall. Macrophages play a crucial role in early-stage cholesterol aggregation during atherosclerosis.
Mengjiao Sun, Hongzhe Ma, Mingru Liu, Mengchan Xia, Yanhua Chen, Zhaoying Wang, Zhanping Li   +6 more
doaj   +1 more source