Results 11 to 20 of about 5,293,958 (301)

Mass Spectrometry Imaging of Metabolites

, 2018
Mass spectrometry imaging (MSI) is a technique which is gaining increasing interest in biomedical research due to its capacity to visualize molecules in tissues. First applied to the field of clinical proteomics, its potential for metabolite imaging in biomedical studies is now being recognized.
Balluff, Benjamin, McDonnell, Liam A.
openaire   +4 more sources

Comparison of Local Metabolic Changes in Diabetic Rodent Kidneys Using Mass Spectrometry Imaging

Metabolites, 2023
Understanding the renal region-specific metabolic alteration in different animal models of diabetic nephropathy (DN) is critical for uncovering the underlying mechanisms and for developing effective treatments.
Xin Zhang, Yanhua Liu, Shu Yang, Xin Gao, Shuo Wang, Zhaoying Wang, Chen Zhang, Zhi Zhou, Yanhua Chen, Zhonghua Wang, Zeper Abliz   +10 more
doaj   +1 more source

Basal ganglia neuropeptides show abnormal processing associated with L-DOPA-induced dyskinesia

npj Parkinson's Disease, 2022
L-DOPA administration is the primary treatment for Parkinson’s disease (PD) but long-term administration is usually accompanied by hyperkinetic side-effects called L-DOPA-induced dyskinesia (LID). Signaling neuropeptides of the basal ganglia are affected
Heather Hulme, Elva Fridjonsdottir, Theodosia Vallianatou, Reza Shariatgorji, Anna Nilsson, Qin Li, Erwan Bezard, Per E. Andrén   +7 more
doaj   +1 more source

Optimized protocol for MALDI MSI of N-glycans using an on-tissue digestion in fresh frozen tissue sections

Scientific Reports, 2023
Glycans play an important role in biology with multiple cellular functions ranging from cell signaling, mobility and growth to protein folding and localization.
Andrej Grgic, Kasper K. Krestensen, Ron M. A. Heeren   +2 more
doaj   +1 more source

Proteomic Analysis of the Cold Stress Response of Ammopiptanthus mongolicus Reveals the Role of AmCHIA in Its Cold Tolerance

Horticulturae, 2023
Ammopiptanthus mongolicus, a traditional ethnic medicinal herb, is a rare broad-leaved evergreen shrub in the arid region of central Asia that can survive under extremely low temperatures during winter.
Xuting Li, Qi Liu, Rongqi Wu, Jie Bing, Lamei Zheng, Batu Sumbur, Yijun Zhou, Fei Gao   +7 more
doaj   +1 more source

Mass Spectrometry Imaging of Biomaterials

Materials, 2023
The science related to biomaterials and tissue engineering accounts for a growing part of our knowledge. Surface modifications of biomaterials, their performance in vitro, and the interaction between them and surrounding tissues are gaining more and more attention. It is because we are interested in finding sophisticated materials that help us to treat
Paulina Kret, Anna Bodzon-Kulakowska, Anna Drabik, Joanna Ner-Kluza, Piotr Suder, Marek Smoluch   +5 more
openaire   +2 more sources

The diagnostic accuracy of intraoperative differentiation and delineation techniques in brain tumours

Discover Oncology, 2022
Brain tumour identification and delineation in a timeframe of seconds would significantly guide and support surgical decisions. Here, treatment is often complicated by the infiltration of gliomas in the surrounding brain parenchyma.
Laura Van Hese, Steven De Vleeschouwer, Tom Theys, Steffen Rex, Ron M. A. Heeren, Eva Cuypers   +5 more
doaj   +1 more source

Comparison of Osteosarcoma Aggregated Tumour Models with Human Tissue by Multimodal Mass Spectrometry Imaging

Metabolites, 2021
Osteosarcoma (OS) is the most common primary bone malignancy and largely effects adolescents and young adults, with 60% of patients under the age of 25. There are multiple cell models of OS described in vitro that express the specific genetic alterations
Lucy E. Flint, Gregory Hamm, Joseph D. Ready, Stephanie Ling, Catherine J. Duckett, Neil A. Cross, Laura M. Cole, David P. Smith, Richard J. A. Goodwin, Malcolm R. Clench   +9 more
doaj   +1 more source

Mass Spectrometry Imaging. [PDF]

Anal Chem
Mass spectrometry imaging (MSI) maps the spatial distributions of chemicals on chemically complex surfaces. MSI offers unrivaled sensitivity and information density with each pixel comprising a mass spectrum. Over the past three decades, numerous technological developments have enabled MSI to evolve into a mainstream technique for untargeted molecular ...
Körber A, Anthony IGM, Heeren RMA.
europepmc   +3 more sources

Simultaneous mass spectrometry imaging of multiple neuropeptides in the brain and alterations induced by experimental parkinsonism and L-DOPA therapy

Neurobiology of Disease, 2020
Neuropeptides are important signalling molecules in the brain and alterations in their expression levels have been linked to neurological disorders such as Parkinson's disease. It is challenging to map neuropeptide changes across and within brain regions
Heather Hulme, Elva Fridjonsdottir, Halla Gunnarsdottir, Theodosia Vallianatou, Xiaoqun Zhang, Henrik Wadensten, Reza Shariatgorji, Anna Nilsson, Erwan Bezard, Per Svenningsson, Per E. Andrén   +10 more
doaj   +1 more source