Results 81 to 90 of about 201,812 (254)

Fast pH‐Driven Solubilization Method of Realgar (As4S4) to Reduce the Toxicity of Arsenic [As(III)] for Medicinal Purposes

Advanced Science, EarlyView.
Arsenic trioxide transformed acute promyelocytic leukemia therapy and shows promise against HIV. A new method to solubilize the mineral realgar produces different arsenic species depleting the main arsenic target, nuclear PML protein, and retaining effects on leukemic and HIV reservoir cells, while minimizing off‐target damage.
Bojana Lucic, Douglas Santana Franciscato, Helton Pereira Nogueira, Lara Gallucci, Alceu Totti Silveira Junior, Asmaa Mohamed Ismail, Millie Robinson, Teresa Dallinger, Claudia Gutfleisch, Jochen Kurz, Maytê Toledo, Jessica Dias da Silva Ferraz, Mohammad Tarek, Danilo Dias, Ricardo Sobhie Diaz, Mahmoud ElHefnawi, Mattia Forcato, Hugo P Monteiro, Marina Lusic, Iart Luca Shytaj, Andrea Savarino   +20 more
wiley   +1 more source

Artificial Intelligent‐Enhanced Metabolite Profiling for Intraoperative IDH1 Genotyping in Glioma Using an Orthogonally Responsive SERS Probe

Advanced Science, EarlyView.
This study presents a novel approach for intraoperative identification of the IDH1 genotype in glioma patients using a surface‐enhanced Raman scattering (SERS) probe to measure glutathione and hydrogen peroxide. By integrating AI‐driven deep learning algorithms, the method achieves rapid and accurate genotype differentiation, offering the potential to ...
Hang Yin, Xin Zhang, Zheng Zhao, Chong Cao, Minhua Xu, Suhongrui Zhou, Tian Xuan, Ziyi Jin, Limei Han, Yang Fan, Cong Wang, Xiao Zhu, Ying Mao, Jinhua Yu, Cong Li   +14 more
wiley   +1 more source

Multi‐Omics and ‐Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset

Advanced Science, EarlyView.
This study shows that patients at risk of sepsis have a distinct metabolite and lipid signature, including serine and aminoadipic acid, in their serum before clinical diagnosis. A mouse model of sepsis with a compatible serum signature reveals underlying metabolic changes, including mitochondrial adaptation, altered serine‐dependent purine metabolism ...
Lin‐Lin Xu, Zhengyuan Zhou, Sascha Schäuble, Wolfgang Vivas, Karen Dlubatz, Michael Bauer, Sebastian Weis, Mervyn Singer, Roman Lukaszewski, Gianni Panagiotou   +9 more
wiley   +1 more source

The E3 Ligase NEDD4L Prevents Colorectal Cancer Liver Metastasis via Degradation of PRMT5 to Inhibit the AKT/mTOR Signaling Pathway

Advanced Science, EarlyView.
Neural precursor cell expressed developmentally down‐regulated gene 4‐like (NEDD4L) prevents colorectal cancer liver metastasis through ubiquitination and degradation of protein arginine methyltransferase 5 (PRMT5). PRMT5 degradation attenuates the methylarginine of AKT1.
Zhewen Dong, Xiaofei She, Junxian Ma, Qian Chen, Yaqun Gao, Ruiyan Chen, Huanlong Qin, Bing Shen, Hua Gao   +8 more
wiley   +1 more source

PHOSPHO1 Suppresses Ferroptosis in Retinal Pigment Epithelial Cells by Reducing the Levels of Phosphatidylethanolamine Molecular Species

Advanced Science, EarlyView.
Iron‐induced lipid peroxidation of phosphatidylethanolamine (PE) species is the key driver of ferroptosis. The authors discovered that PHOSPHO1 lowers the level of PE in retinal pigment epithelial cells thus reducing the formation of lipid peroxides. Lowering PE levels can also prevent the creation of autolysosomes, reduce the production of free iron ...
Zhiyang Chen, Xiaoman Zhu, Michael Mingze Lu, Qingjian Ou, Xueying Wang, Zhenzhen Zhao, Qi Shen, Qian Wang, Zhe Wang, Jing‐Ying Xu, Caixia Jin, Furong Gao, Juan Wang, Jingfa Zhang, Jieping Zhang, Xiaoliang Jin, Yanlong Bi, Lixia Lu, Guo‐Tong Xu, Haibin Tian   +19 more
wiley   +1 more source

Mechanism of Cationic Peptide‐Induced Assembly of Gold Nanoparticles: Modulation of Electrostatic Repulsion

Aggregate, EarlyView.
Cationic peptides aggregate citrate‐capped gold nanoparticles (AuNPs), producing a colorimetric change. The figure highlights the interplay between the intermolecular attractive and repulsive forces governing the colloidal stability of the nanoparticles.
Benjamin Lam, Robert Ramji, Margaret Mullooly, Kristina D. Closser, Tod A. Pascal, Jesse V. Jokerst   +5 more
wiley   +1 more source

Construction of Active Sites‐Accessible Au8 Clusters for Intensive Tumor Pyroptosis

Aggregate, EarlyView.
Ethynylferrocene (EFc) was utilized to engineer molecular‐like gold nanoclusters (NCs) with accessibly catalytic centers, resulting in NCs exhibiting excellent peroxidase‐like activity and the ability to radiosensitize, leading to the production of intracellular oxidative stress and activation of pyroptosis.
Qiu‐Xu Zang, Wei‐Tong Chen, Wenjing Zhang, Zhao‐Yang Wang, Xi‐Yan Dong, Runping Han, Yanjuan Sang, Xiaoyuan Chen, Shuang‐Quan Zang   +8 more
wiley   +1 more source

Chemodiversity of dissolved organic matter in the Amazon Basin [PDF]

, 2016
Regions in the Amazon Basin have been associated with specific biogeochemical processes, but a detailed chemical classification of the abundant and ubiquitous dissolved organic matter (DOM), beyond specific indicator compounds and bulk measurements, has ...
Bastos, Wanderley, Bastviken, David, Enrich-Prast, Alex, Gonsior, Michael, Harir, Mourad, Hertkorn, Norbert, Luek, Jenna L., Schmitt-Kopplin, Philippe, Valle, Juliana   +8 more
core   +1 more source

Full‐Color Tunable Fluorescent Polysiloxanes Driven by Structure Evolution and Aggregation From Amine–Aldehyde Reaction

Aggregate, EarlyView.
To achieve full‐color nonconventional fluorescence, amino‐terminated polysiloxanes are introduced into the amine–glutaraldehyde reaction. The fluorophore evolution from imines to pyridinium derivatives, along with aggregate state regulation, is precisely controlled by thermal treatment.
Cheng Huang, Xinyu Cao, Xianpeng Fan, Lvyin Wang, Jingnan Zhang, Gang Ye, Haijiao Xie, Yongmei Ma   +7 more
wiley   +1 more source

Development of an Automated Workflow for Screening the Assembly and Host–Guest Behavior of Metal‐Organic Cages Towards Accelerated Discovery

Angewandte Chemie, EarlyView.
An automated experimental workflow to accelerate the discovery of metal‐organic cages (MOCs), which is often hindered by slow, manual approaches, has been developed. Automation of the synthesis, characterization, and analysis, is supported by computational modelling to rationalize the experimental outcomes, and development of a host–guest assay ...
Annabel R. Basford, Aaron H. Bernardino, Paula C. P. Teeuwen, Benjamin D. Egleston, Joshua Humphreys, Kim. E. Jelfs, Jonathan R. Nitschke, Imogen A. Riddell, Rebecca L. Greenaway   +8 more
wiley   +2 more sources