Results 131 to 140 of about 3,602,918 (298)

The analysis of collision induced dissociation of rhodium and osmium carbonyl clusters by energy-dependent electrospray ionisation mass spectrometry

The derivatization of neutral transition metal carbonyl clusters with an alkoxide anion, [Mn(CO)xOR]- is discussed. The electrospray ionization mass spectrometry technique is used for the purpose.
Whyte, C., Langridge-Smith, P.R.R., Dyson, Paul Joseph, McIndoe, J.S.   +3 more
core  

Lecture 14: Structure of Synaptic Vesicle Electrospray Ionization Mass Spectrometry

, 2015
This biochemistry lecture deals with the characterization of the lipid component of a synaptic vesicle. The principal characterization technique, electrospray ionization mass spectrometry, ESI-mass spec, is also ...
Winter, Nathan S.
core  

Identification of catecholamines in the immune system by electrospray ionization mass spectrometry

, 1998
The first evidence that catecholamines might be present in the immune system was provided by capillary electrophoresis combined with electrochemical detection.
Bergquist, Jonas,, Silberring, J,
core   +1 more source

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

Characterization of Anticancer Drug Protomers Using Electrospray Ionization and Ion Mobility Spectrometry–Mass Spectrometry [PDF]

We used electrospray ionization and ion mobility spectrometry–mass spectrometry to detect and characterize the three anticancer drugs palbociclib, copanlisib, and olaparib.
Safferthal, Marc, Riedel, Jerome, Pagel, Kevin, Schorr, Pascal, Basuri, Pallab, Kovacevic, Borislav, Volmer, Dietrich A.   +6 more
core   +1 more source

A Postbiotic‐Inducing Ganoderma applanatum Polysaccharide Repairs the Intestinal Barrier via a Phocaeicola vulgatus ‐ Tridecylic Acid Axis

Advanced Science, EarlyView.
This study identifies GAP2, a bioactive polysaccharide fraction derived from Ganoderma applanatum, as a postbiotic inducer that repairs intestinal barrier damage in a gut microbiota‐dependent manner. GAP2 enriches Phocaeicola vulgatus, which degrades GAP2 and promotes tridecylic acid production, triggering Rho/CDC42 signaling and tight‐junction ...
Chuan Zhang, Miaoyu Li, Tiantian Li, Xiaojie Zang, Haiyang Shi, Yaru Liu, Chengcheng Zhang, Jianxin Zhao, Qixiao Zhai, Wei Chen, Fengwei Tian   +10 more
wiley   +1 more source

3D Bioprinted Blood–Brain–Tumor Barrier Spheroid‐Based In Situ Evaluation of Anticancer Compounds Against Glioblastoma: ROS‐Producing Ruthenium as a Potential Therapeutic Candidate

Advanced Science, EarlyView.
The blood–brain–tumor barrier (BBTB) penetration by anticancer drugs and their effects on glioblastoma (GBM) is assessed using 3D bioprinted‐spheroids. Anticancer drug‐induced U‐87 MG cell death is quantified through in situ imaging of spheroids using a cancer cell death probe. The Ru compound, a partial P‐gp substrate, induces greater tumor‐cell death
Hyunjung Lee, Chan Ho Jeon, Doyun Kim, Minjae Lee, Minji Kwon, Joon Myong Song   +5 more
wiley   +1 more source

Electrospray ionization tandem mass spectrometry of 4-aryl-3,4-dihydrocoumarins [PDF]

We have investigated the gas-phase fragmentation reactions of eleven synthetic 4-aryl-3,4-dihydrocoumarins by electrospray ionization tandem mass spectrometry (ESI-MS/MS) on a quadrupole-time-of flight (Q-TOF) hybrid mass spectrometer.
William, Santos, Herbert, Dias, Eduardo, Crevelin, J. Scott, McIndoe, Luiz Carlos, Silva-Filho, Antônio, Crotti, Ricardo, Vessecchi   +6 more
core   +2 more sources

A Dual‐Delivery System Designed to Overcome EV‐Mediated Ferroptosis Resistance for Efficient Solid Tumor Therapy

Advanced Science, EarlyView.
(A) Establishment and characterization of the osteosarcoma‐targeted dual‐delivery nanoplatform mBAP1/siENO1@LNP‐OTP for simultaneous regulation of BAP1 and ENO1 in tumor cells. (B) After intravenous administration, mBAP1/siENO1@LNP‐OTP preferentially accumulates at tumor sites through OTP‐mediated targeting.
Yechao Shen, Zhenguo Cao, Zenan Wang, Liang Chen, Jiahao Zhang, Linjie Zeng, Boren Tan, Hengyuan Li, Jiashan Lai, Jiangchu Lei, Fanglu Chen, Peng Lin, Zhenxuan Shao, Zhan Wang   +13 more
wiley   +1 more source