Results 261 to 270 of about 441,409 (379)

Engineering and Structural Elucidation of a Sac7d‐Derived IgG Fc‐Specific Affitin and Its Application for the Light‐Controlled Affinity Purification of Antibodies

open access: yesChemBioChem, EarlyView.
An affitin derived from the Sac7d scaffold enables the light‐controlled affinity purification of antibodies under physiological conditions, thus overcoming limitations of protein A chromatography. X‐ray crystallographic analysis and affinity measurements reveal complex formation with Fc at the CH2/CH3 junction, similar to protein A/G and FnRn. Combined
Felix Veitl   +7 more
wiley   +1 more source

Tumor-Promoted Changes in Pediatric Brain Histology Can Be Distinguished from Normal Parenchyma by Desorption Electrospray Ionization Mass Spectrometry Imaging. [PDF]

open access: yesBiomedicines
Seidinger AL   +16 more
europepmc   +1 more source

Boron‐Based Functionalities Enhance, the Potency of 2,5‐Dimethylfuran‐Based IDO1 Inhibitors

open access: yesChemBioChem, EarlyView.
‐, , , ‐ , Indoleamine‐2,3‐dioxygenase‐1 (IDO1), a key immunoregulatory enzyme, is inhibited by novel boron derivatives (closo‐1,2‐ and 1,7‐carborane, boronic acids and esters, and benzoxaboroles) of 2,5‐dimethylfuran, each displaying low μM affinity for the human recombinant enzyme.
Thomas J. C. Carraro   +4 more
wiley   +1 more source

Mitochondria‐Catalyzed Activation of Anticancer Prodrugs

open access: yesChemCatChem, Accepted Article.
Mitochondria mediate electron transport chain (ETC) to power ATP synthase. In cancer cells, the ETC is disturbed leading to leakage of electron that ultimately results in generation of H2O2. This difference between cancer and healthy cells can be used for the design of cancer‐specific prodrugs as confirmed in several proof‐of‐concept studies ...
Michael Raucheisen   +7 more
wiley   +1 more source

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