This short review aims to summarize the current developments and applications of mass spectrometry-based methods for in situ profiling and imaging of plants with minimal or no sample pre-treatment or manipulation.
Aleš eSvatoš, Benjamin eBartels
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High throughput analysis is increasingly relevant in both industry and academia, with applications reaching from enzymology and drug discovery to organic reaction optimization and diagnostics.
Nicolás M. Morato, R. Graham Cooks
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Shotgun lipidomics of cardiolipin molecular species in lipid extracts of biological samples
Cardiolipin is a prominent component of the mitochondrial inner membranes contributing to the regulation of multiple discrete mitochondrial functions. Here, we extend shotgun lipidomics to identify and quantitate cardiolipin molecular species directly ...
Xianlin Han +4 more
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Structural Plasticity and Noncovalent Substrate Binding in the GroEL Apical Domain. A study using electrospray ionization mass spectrometry and fluorescence binding studies [PDF]
Advances in understanding how GroEL binds to non-native proteins are reported. Conformational flexibility in the GroEL apical domain, which could account for the variety of substrates that GroEL binds, is illustrated by comparison of several independent ...
Adams +62 more
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Analysis of Oligonucleotides by Electrospray Ionization Mass Spectrometry [PDF]
AbstractBecause of the high molecular weights and thermal lability of biomolecules such as nucleic acids and protein, they can be difficult to analyze by mass spectrometry. Such analyses require a “soft” ionization method that is capable of generating intact molecular ions.
Polo, Lenore M., Limbach, Patrick A.
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Recent advances in experimental techniques to probe fast excited-state dynamics in biological molecules in the gas phase : dynamics in nucleotides, amino acids and beyond [PDF]
In many chemical reactions, an activation barrier must be overcome before a chemical transformation can occur. As such, understanding the behaviour of molecules in energetically excited states is critical to understanding the chemical changes that these ...
Hadden DJ +6 more
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Further characterization of glycine-containing microcystins from the McMurdo Dry Valleys of Antarctica [PDF]
Microcystins are hepatotoxic cyclic peptides produced by several cyanobacterial genera worldwide. In 2008, our research group identified eight new glycine-containing microcystin congeners in two hydro-terrestrial mat samples from the McMurdo Dry Valleys ...
Cary, S. Craig +5 more
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Ionization and transmission efficiency in an electrospray ionization—mass spectrometry interface [PDF]
The ionization and transmission efficiencies of an electrospray ionization (ESI) interface were investigated to advance the understanding of how these factors affect mass spectrometry (MS) sensitivity. In addition, the effects of the ES emitter distance to the inlet, solution flow rate, and inlet temperature were characterized.
Page, Jason S. +3 more
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Determination of parabens in human urine by liquid chromatography coupled with electrospray ionization tandem mass spectrometry [PDF]
A simple and sensitive method was developed for the simultaneous determination of methyl, ethyl,n-propyl,n-butyl, and benzyl parabens in human urine by liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS).
Fu, Jiamo +6 more
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Plasmodium vivax is a common cause of imported malaria in the USA, second only to P. falciparum. We present a case of P. vivax malaria in a child returning from India. P.
Megan A Rounds +5 more
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