Results 291 to 300 of about 441,409 (379)
Chemistry – A European Journal, Accepted Article.While Earth‐abundant metals are green and sustainable alternatives to precious metals for catalytic chemical conversions, the fast ligand exchange involving most of the base metals renders their development into robust, reusable catalysts very challenging.
Yi-Xiang Shi +7 more
wiley +1 more source
Conception and synthesis of sequence‐coded morpholinos
Chemistry – A European Journal, Accepted Article.Solid‐phase morpholino chemistry was explored as a new route to synthesize abiological sequence‐defined oligomers. Two comonomers 0 and 1 containing (i) a chlorophosphoramidate reactive function, (ii) a trityl‐protected morpholine and (iii) a coding substituent (H or CH3 for 0 and 1, respectively) on the morpholine ring were first synthesized and ...
Benoit Pousse +4 more
wiley +1 more source
ChemMedChem, EarlyView.This study presents a β‐glucuronidase‐responsive albumin‐binding prodrug enabling the selective release within the tumor microenvironment of an Isocombretastatin A‐4 analog. In triple‐negative breast cancer (TNBC) mouse models, this prodrug demonstrated significant tumor growth inhibition, highlighting potential for enhanced therapeutic selectivity and
Alexandra Bordes +6 more
wiley +1 more source
Uncovering Distinct Peptide Charging Behaviors in Electrospray Ionization Mass Spectrometry Using a Large-Scale Dataset. [PDF]
J Am Soc Mass SpectromXu AM, Tang LC, Jovanovic M, Regev O.
europepmc +1 more source
Design and Synthesis of Tetrahydropyrrolo[3,4‐c]Pyrazole Sigma‐1 Receptor Ligands
ChemMedChem, EarlyView.This study highlights the tetrahydropyrrolo[3,4‐c]pyrazole scaffold as a promising platform for S1R ligands development. Key findings include compound 19’s high S1R affinity (Ki=75 nM), influenced by strategic nitrogen substitutions and reduced steric hindrance.
Giuseppe Cosentino +7 more
wiley +1 more source
ChemMedChem, Accepted Article.The cylcooxygenase isoforms COX‐1 and COX‐2 are involved in the production of prostaglandins in physiological and pathological processes. The overexpression of COX‐2 under inflammatory conditions as well as its role in cancer and neurodegenerative diseases necessitates the need to develop and improve non‐steroidal anti‐inflammatory drugs.
Lea Ueberham +8 more
wiley +1 more source
Desorption Electrospray Ionization Mass Spectrometry Imaging Techniques Depict a Reprogramming of Energy and Purine Metabolism in the Core Brain Regions of Chronic Social Defeat Stress Mice. [PDF]
MetabolitesSong Y, Xiao F, Aa J, Wang G.
europepmc +1 more source
Chemistry–Methods, EarlyView.This study develops a convenient approach to investigate cyanoarene photocatalysts with anion‐enhanced detection AED‐ESI‐HRMS through the signal‐amplified interaction with bromide anions. By combining supramolecular chemistry, DFT calculations, and mass spectrometry, we uncover a novel approach for tracking photocatalyst transformations and elucidating
Nikita S. Shlapakov +5 more
wiley +1 more source