Results 311 to 320 of about 441,409 (379)

Recycling of Polyurethane via Mechanocatalytic Methanolysis/Hydrolysis

ChemSusChem, EarlyView.
In this study, it is shown that up to 86% of soluble polyol can be recovered from the hydrolysis of polyurethane using a ball milling‐assisted process below 100 °C in the presence of NaOH, a small amount of H2O and a Cu/MgAlOx co‐catalyst. Polyurethane (PU) is the 6th most produced plastic on a global basis, and thus one of the most important targets ...
Bolun Wang, Joel Britschgi, Nguyen Khang Tran, Ivana Jevtovikj, Piyush Ingale, Cansu Mai, Stephan Andreas Schunk, Ferdi Schüth   +7 more
wiley   +1 more source

Simultaneous detection of three hypoxia‐inducible factor stabilizers—molidustat, roxadustat, and vadadustat—in multiple keratinized matrices and its application in a doping context

Drug Testing and Analysis, EarlyView.
The authors present a method for the simultaneous identification and quantification of three HIF stabilizers in multiple keratinized matrices, with the first identification of molidustat in hair, beard hair and fingernails in an authentic doping case.
Anne Checkouri, Laurie Gheddar, Nadia Arbouche, Jean‐Sébastien Raul, Pascal Kintz   +4 more
wiley   +1 more source

In vitro metabolism study of ADB‐P‐5Br‐INACA and ADB‐4en‐P‐5Br‐INACA using human hepatocytes, liver microsomes, and in‐house synthesized references

Drug Testing and Analysis, EarlyView.
Analyzing hepatocytes and liver microsomes samples along with synthesized references. Complete structure elucidation of major metabolites was possible, and biomarkers for both ADB‐P‐5Br‐INACA and ADB‐4en‐P‐5Br‐INACA were suggested. Abstract Synthetic cannabinoids (SCs) remain a major public health concern, as they continuously are linked to severe ...
Tobias Rautio, Robin Obrist, Lucas Krebs, Therése Klingstedt, Johan Dahlén, Xiongyu Wu, Henrik Gréen   +6 more
wiley   +1 more source

High-throughput label-free opioid receptor binding assays using an automated desorption electrospray ionization mass spectrometry platform.

Chem Commun (Camb)
Feng Y, Morato NM, Huang KH, Lin M, Cooks RG.   +4 more
europepmc   +1 more source

Interest of hair tests to discriminate a tail end of a doping regimen from a possible contamination in case of challenging an anti‐doping rule violation. V. Case reports involving trimetazidine, a drug where the concentration after a single 20 mg dose has been established

Drug Testing and Analysis, EarlyView.
From ingestion to hair incorporation Abstract The identification of trimetazidine, a medicine used for treating stable angina pectoris and for preventing angina attacks, has been recently observed in doping cases involving high profile athletes from various countries over the world.
Pascal Kintz, Alice Ameline, Laurie Gheddar   +2 more
wiley   +1 more source

Mercaptans in malodorants break disulfide bridges in human serum albumin and form adducts suitable as biomarkers of exposure in vitro

Drug Testing and Analysis, EarlyView.
Disulfide adducts of mercaptans with cysteine residues in human serum albumin were detected as tripeptides and dipeptides after proteolysis with proteinase K. All peptide adducts were detected simultaneously with a mass spectrometry‐based method working in the scheduled multiple reaction monitoring (sMRM) mode.
Paula Helena Sieber, Dirk Steinritz, Franz Worek, Harald John   +3 more
wiley   +1 more source

High‐throughput liquid chromatography‐vacuum differential mobility spectrometry‐mass spectrometry for the analysis of isomeric drugs of abuse in human urine

Drug Testing and Analysis, EarlyView.
This report describes the potential of vacuum differential mobility spectrometry (DMS) as an additional separation dimension to reduce liquid chromatography (LC‐MS) analysis time while maintaining good quantitative performance. A 1‐min trap/elute LC‐vDMS‐SIM/MS method for quantification of 11 drugs of abuse was developed and applied to the analysis of ...
Maria Fernanda Cifuentes Girard, Patrick Knight, Gérard Hopfgartner   +2 more
wiley   +1 more source

Metabolism study of 3‐chloromethcathinone (3‐CMC) by dried blood spot (DBS) sampling after controlled administration using a murine model

Drug Testing and Analysis, EarlyView.
The metabolism of 3‐chloromethcathinone (3‐CMC) was studied after controlled administration in a murine model using the dried blood spot (DBS) technique for the sampling, storage and purification of blood samples. The metabolite profile of 3‐CMC was studied by LC‐HRMS, while the stability of 3‐CMC and its three identified metabolites was also assessed ...
Serena Mestria, Sara Odoardi, Valeria Valentini, Giorgia Corli, Marta Bassi, Matteo Marti, Sabina Strano‐Rossi   +6 more
wiley   +1 more source

Interlaboratory comparison of phosphatidylethanol in dried blood spots using different sampling devices

Drug Testing and Analysis, EarlyView.
In this article, we present the results of three rounds of interlaboratory comparison conducted in 2022 and 2023 for phosphatidylethanol (PEth) in authentic fresh blood samples using different types of microsampling devices. More than 20 laboratories from Europe and the US participated, and 73% quantified and reported all 12 samples covering a range ...
Matthias Bantle, Frederike Stöth, Wolfgang Weinmann, Marc Luginbühl   +3 more
wiley   +1 more source

Identification of human metabolites of fast skeletal troponin activators Tirasemtiv and Reldesemtiv for doping control purposes

Drug Testing and Analysis, EarlyView.
The metabolism and urinary elimination of two substances recently classified as prohibited substances in sport was conducted, yielding suitable target analytes for efficient doping controls employing routinely applied chromatographic‐mass spectrometric test methods.
Luisa Euler, Kim Deinert, Felicitas Wagener, Katja Walpurgis, Mario Thevis   +4 more
wiley   +1 more source