Results 191 to 200 of about 776,948 (400)

Discovering Uncharted Binding Pockets on E3 Ligases Leads to the Identification of FBW7 Allosteric Modulators

Advanced Science, EarlyView.
A computational approach to identify and characterize ligandable binding pockets on E3 ligases is presented. As a validation case, the first low‐micromolar small moleculesthat bind to the FBW7 E3 ligase are identified and confirmed to bind at the intended site.
Míriam Martínez‐Cartró, Álvaro Serrano‐Morrás, Andrea Bertran‐Mostazo, Roger Castaño‐Muñiz, Salvatore Scaffidi, Varbina Ivanova, Noémi Csorba, József Simon, Péter Ábrányi‐Balogh, Yunfeng Li, György M. Keserü, Bing Hao, Xavier Barril, Carles Galdeano   +13 more
wiley   +1 more source

Comprehensive Genetic Map of Muscle Lipidome Reveals Novel Insights Into Flavor Variation in Ruminant Meat

Advanced Science, EarlyView.
Ruminant meat is widely appreciated for its distinctive flavor. Lipids play a central role in influencing meat flavor, yet their genetic and biochemical basis remains largely unexplored. Here, a comprehensive lipid genetic map of sheep muscle is constructed and 20 candidate genes potentially modulating lipid levels are identified to provide a roadmap ...
Xueying Zhang, Yuanyuan Kong, Jialei Chen, Ran Li, Zhongyu Wang, Yali Song, Tianshu Dai, Yuxin Fu, Beixiang Jiang, Jize Zeng, Shengwei Pei, Yangkai Liu, Qianjie Feng, Weiwei Fu, Zehu Yuan, Joram Mwashigadi Mwacharo, Fadi Li, Xiangpeng Yue   +17 more
wiley   +1 more source

Forensic DNA fingerprinting by liquid chromatography-electrospray ionization mass spectrometry

BioTechniques, 2007
Herbert Oberacher, Walther Parson
doaj   +1 more source

On-Line Capillary Electrophoresis-Electrospray Mass Spectrometry for the Analysis of Pharmaceuticals

, 1999
Samir Cherkaoui, Serge Rudaz, Emmanuel Varesio, Jean‐Luc Veuthey   +3 more
openalex   +2 more sources

Methylmalonic Acid Measured in Plasma and Urine by Stable-Isotope Dilution and Electrospray Tandem Mass Spectrometry [PDF]

, 2000
Mark J Magera, Janice K Helgeson, Dietrich Matern, Piero Rinaldo   +3 more
openalex   +1 more source

A Lipid with Lewis Pair‐Mediated Targeting and Multiple Stimuli‐Responsive Delivery of Antibiotics for Bacterial Infections

Advanced Science, EarlyView.
Lewis pair‐integrated lipids (Lp‐lipids), combining targeted delivery and stimuli‐responsive are developed for antibiotic delivery. These lipids form nanoparticles that bind biofilms via boronate ester bonds and respond to acidic pH, H2O2, and ATP, enabling controlled drug release.
Xiaojian Yan, Lei Hua, Hongping Wan, Yong Liu, Tao Jin, Yicen Ge, Michael R Hamblin, Mahdi Karimi, Xinghong Zhao, Yan Hu, Linqi Shi, Yuanfeng Li   +11 more
wiley   +1 more source

Conformational Changes of Proteins Observed by Hydrogen/Deuterium Exchange and Electrospray Ionization Mass Spectrometry.

, 1998
Satoko Akashi, Koji Takio
openalex   +2 more sources

H3K27ac Is Essential for Human Naive Pluripotency Modulated by m6A‐Driven EP300 Expression

Advanced Science, EarlyView.
An et al. reveal H3K27ac elevation is essential for establishing and maintaining human naive pluripotency; its inhibition disrupts this state while enhancement promotes it. METTL3‐mediated m6A modification indirectly controls H3K27ac by suppressing EP300 expression. Reduced EP300 lowers H3K27ac, impeding naive pluripotency.
Chenrui An, Ke Zhong, Xiangjin Kang, Yingying Zhang, Yudan Shang, Hao Liu, Yushan Ji, Jinbei Zeng, Jiajin Lin, Long Jin, Zelong Lin, Yang Yu, Xuetao Shi, Yong Fan   +13 more
wiley   +1 more source

Analysis of short tandem repeat polymorphisms by electrospray ion trap mass spectrometry [PDF]

, 2000
Stefanie Hahner
openalex   +1 more source

Dual‐Wavelength Responsive Hydrogel Glue with Visible‐Light Bonding and UV‐Triggered Debonding via Ortho‐Nitrobenzyl Cleavage

Advanced Science, EarlyView.
A dual‐wavelength responsive hydrogel glue achieves orthogonal control of bonding and debonding: visible light drives crosslinking via acrylic acid, while ortho‐nitrobenzyl (ONB) units enable rapid UV‐triggered network cleavage. This smart adhesive offers strong adhesion, fast on‐demand debonding, and spatiotemporal precision for potential applications
Huaming Wang, Xianyan Shen, Changling Du, Xian‐You Liu, Anyu Yang, Yanni Cao, Aijie Han, Qihan Liu, Jennifer Laaser, Wei Zhang   +9 more
wiley   +1 more source